Results 231 to 240 of about 786,701 (285)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Theory and evidence-base for a digital platform for the delivery of language tests during awake craniotomy and collaborative brain mapping. [PDF]

BMJ Surg Interv Health Technol
Veljanoski D, Ng XY, Hill CS, Jamjoom AAB.   +3 more
europepmc   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Whole-brain mapping of increased manganese levels in welders and its association with exposure and motor function. [PDF]

Neuroimage
Monsivais H, Yeh CL, Edmondson A, Harold R, Snyder S, Wells EM, Schmidt-Wilcke T, Foti D, Zauber SE, Dydak U.   +9 more
europepmc   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Whole Brain Mapping of Orexin Receptor mRNA Expression Visualized by Branched In Situ Hybridization Chain Reaction. [PDF]

eNeuro
Tsuneoka Y, Funato H.
europepmc   +1 more source

A priori free spectral unmixing with periodic absorbance changes: application for auto-calibrated intraoperative functional brain mapping. [PDF]

Biomed Opt Express
Caredda C, Cohen JE, Mahieu-Williame L, Sablong R, Sdika M, Schneider FC, Picart T, Guyotat J, Montcel B.   +8 more
europepmc   +1 more source

3D Creatine Kinase Imaging (CKI) for In Vivo Whole-Brain Mapping of Creatine Kinase Reaction Rates with 31P-Magnetization Transfer MR Fingerprinting

Widmaier MS, Kaiser A, Lim S, Pandurevic P, Döring A, Huang Z, Wenz D, Xiao Y, Jiang Y, Xin L.   +9 more
europepmc   +1 more source

ABBA, a novel tool for whole-brain mapping, reveals brain-wide differences in immediate early genes induction following learning

Chiaruttini N, Castoldi C, Requie LM, Camarena-Delgado C, dal Bianco B, Gräff J, Seitz A, Silva BA.   +7 more
europepmc   +1 more source

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Neuropathological Brain Mapping

Dementia and Geriatric Cognitive Disorders, 1997
Neuropathological brain mapping is enabled by extensive semiserial sectioning with whole brain coronal microscopical sections prepared from every 5 to 15 mm. By this method not only type of change but also distribution and regional severity can be assessed, which is fundamental for a correct neuropathological diagnosis.
A, Brun, E, Englund
openaire   +2 more sources