Results 251 to 260 of about 3,008,515 (314)

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Whole-brain mapping of basal forebrain cholinergic neurons reveals a long-range reciprocal input-output loop between distinct subtypes. [PDF]

Sci Adv
Chen Z, Liu Y, Yang Y, Wang L, Qin M, Jiang Z, Xu M, Zhang S.   +7 more
europepmc   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Whole-brain Mapping of Inputs and Outputs of Specific Orbitofrontal Cortical Neurons in Mice. [PDF]

Neurosci Bull
Zhang Y, Zhang W, Wang L, Liu D, Xie T, Le Z, Li X, Gong H, Xu XH, Xu M, Yao H.   +10 more
europepmc   +1 more source

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi, Enrique Gonzalez Saez‐Diez, Joshua Rong, Beril Ay, Shabbir Merchant, Kathryn Yang, Darius Ebrahimi‐Fakhari   +6 more
wiley   +1 more source

Ultra high density imaging arrays in diffuse optical tomography for human brain mapping improve image quality and decoding performance. [PDF]

Sci Rep
Markow ZE, Trobaugh JW, Richter EJ, Tripathy K, Rafferty SM, Svoboda AM, Schroeder ML, Burns-Yocum TM, Bergonzi KM, Chevillet MA, Mugler EM, Eggebrecht AT, Culver JP.   +12 more
europepmc   +1 more source

Individualized functional brain mapping machine learning prediction of symptom-change resulting from selective kappa-opioid antagonism in an anhedonic sample from a Fast-Fail trial. [PDF]

J Mood Anxiety Disord
Sacchet MD, Valenti JL, Keshava P, Walsh SW, Smoski MJ, Krystal AD, Pizzagalli DA.   +6 more
europepmc   +1 more source

A large-scale c-Fos brain mapping study on extinction of cocaine-primed reinstatement. [PDF]

Neuropsychopharmacology
Lenoir M, Engeln M, Navailles S, Girardeau P, Ahmed SH.   +4 more
europepmc   +1 more source

Whole-brain mapping of afferents to the anterior cingulate cortex in adult mice. [PDF]

Mol Pain
Xue M, Chen QY, Shi W, Zhou Z, Li X, Xu F, Bi G, Yang X, Lu JS, Zhuo M.   +9 more
europepmc   +1 more source