Results 71 to 80 of about 796,056 (335)
TMIC-46. SINGLE-CELL MAPPING OF HUMAN BREAST CANCER BRAIN METASTASES REVEALS PROGNOSTICALLY RELEVANT IMMUNE LANDSCAPES [PDF]
, 2023 Lena Jassowicz +11 more
openalex +1 more source
Modern Brain Mapping – What Do We Map Nowadays? [PDF]
Frontiers in Psychiatry, 2015 The problem of function localization in the brain is one of the most fundamental in neuroscience. There are two opposite paradigms relating to the problem: “modularism,” also known as “localism,” versus “holism,” which have been discussed for a long time (1, 2). The debate in favor of one or another view can still be traced at all methodological levels
Maria eNazarova +3 more
openaire +3 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Intracranial hypertension as an initial clinical manifestation of Systemic Lupus Erythematosus
Interdisciplinary Neurosurgery, 2019 Background: Systemic Lupus Erythematosus (SLE) is an auto-immune systemic disorder that may affect multiple organ systems including central nervous system.
Hossein Kalanie +2 more
doaj +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents
NeuroImage: Clinical, 2015 Endophenotypes are heritable and quantifiable markers that may assist in the identification of the complex genetic underpinnings of psychiatric conditions. Here we examined global hypoconnectivity as an endophenotype of autism spectrum conditions (ASCs).
R.L. Moseley +9 more
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Frontiers in Behavioral Neuroscience, 2009 The salience hypothesis of psychosis rests on a simple but profound observation that subtle alterations in the way that we perceive and experience stimuli have important consequences for how important these stimuli become for us, how much they draw our ...
Philip R Corlett +7 more
doaj +1 more source
A Neurobiologically Motivated Analysis of Distributional Semantic Models [PDF]
, 2018 The pervasive use of distributional semantic models or word embeddings in a variety of research fields is due to their remarkable ability to represent the meanings of words for both practical application and cognitive modeling.
Utsumi, Akira
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source