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Targeting brain metastases in breast cancer.
Cancer Treatment Reviews, 2021Brain metastases (BMs) are an important source of morbidity and mortality in patients with metastatic breast cancer (BC). As survival of patients with advanced BC considerably improved thanks to research advancements and new therapeutic approaches, the ...
C. Corti +7 more
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Neurologic Clinics, 2018
Brain metastases from solid tumors are associated with increased morbidity and mortality. Standard treatment is local therapy with surgery and/or radiation therapy although there is increasing interest in systemic therapies that can control both intracranial and extracranial disease. We review the most recent data for local therapy and systemic therapy
Ayal A, Aizer, Eudocia Q, Lee
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Brain metastases from solid tumors are associated with increased morbidity and mortality. Standard treatment is local therapy with surgery and/or radiation therapy although there is increasing interest in systemic therapies that can control both intracranial and extracranial disease. We review the most recent data for local therapy and systemic therapy
Ayal A, Aizer, Eudocia Q, Lee
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The genomic landscape of breast cancer brain metastases: a systematic review.
The Lancet Oncology, 2021Breast cancer brain metastases are an increasing clinical problem. Studies have shown that brain metastases from breast cancer have a distinct genomic landscape to that of the primary tumour, including the presence of mutations that are absent in the ...
A. Morgan, A. Giannoudis, C. Palmieri
semanticscholar +1 more source
Current Opinion in Neurology, 2005
Brain metastases occur in 10-30% of cancer patients, and they are associated with a dismal prognosis. Radiation therapy has been the mainstay of treatment for patients without surgically treatable lesions. For patients with good prognostic factors and a single metastasis, surgical resection is recommended.
Andrew D, Norden +2 more
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Brain metastases occur in 10-30% of cancer patients, and they are associated with a dismal prognosis. Radiation therapy has been the mainstay of treatment for patients without surgically treatable lesions. For patients with good prognostic factors and a single metastasis, surgical resection is recommended.
Andrew D, Norden +2 more
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Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases
Nature MedicineBrain metastases frequently develop in patients with non-small cell lung cancer (NSCLC) and are a common cause of cancer-related deaths, yet our understanding of the underlying human biology is limited. Here we performed multimodal single-nucleus RNA and
Somnath Tagore +49 more
semanticscholar +1 more source
Neurologic Clinics, 1991
Brain metastases are the most common intracranial tumors and affect 20% to 30% of patients with systemic cancer. Improvements in diagnostic imaging and recent advances in treatment have resulted in extension of survival and decreased morbidity due to neurologic causes.
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Brain metastases are the most common intracranial tumors and affect 20% to 30% of patients with systemic cancer. Improvements in diagnostic imaging and recent advances in treatment have resulted in extension of survival and decreased morbidity due to neurologic causes.
openaire +2 more sources
Neurologic Clinics, 2007
Brain metastases are a common complication of cancer and alter patient management more than metastases at any other site of distant progression. Supportive therapies include steroids and antiseizure medications. Definitive treatments include radiation therapy, surgery, and chemotherapy.
Teri D, Nguyen, Lisa M, DeAngelis
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Brain metastases are a common complication of cancer and alter patient management more than metastases at any other site of distant progression. Supportive therapies include steroids and antiseizure medications. Definitive treatments include radiation therapy, surgery, and chemotherapy.
Teri D, Nguyen, Lisa M, DeAngelis
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Neurologic Clinics, 2003
Brain metastases are one of the most feared complications of cancer because even small tumors may cause incapacitating neurologic symptoms. This article reviews the epidemiology, clinical features, treatment, and prognosis of brain metastases from system malignancies.
Andrew B, Lassman, Lisa M, DeAngelis
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Brain metastases are one of the most feared complications of cancer because even small tumors may cause incapacitating neurologic symptoms. This article reviews the epidemiology, clinical features, treatment, and prognosis of brain metastases from system malignancies.
Andrew B, Lassman, Lisa M, DeAngelis
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Current Treatment Options in Oncology, 2000
Brain metastases are an increasingly common complication in patients with systemic cancer. The optimal treatment for each patient depends on careful evaluation of several factors: the location, size, and number of brain metastases; the patient's age, general condition, and neurologic status; and the extent of systemic cancer to name a few. For patients
P Y, Wen, J S, Loeffler
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Brain metastases are an increasingly common complication in patients with systemic cancer. The optimal treatment for each patient depends on careful evaluation of several factors: the location, size, and number of brain metastases; the patient's age, general condition, and neurologic status; and the extent of systemic cancer to name a few. For patients
P Y, Wen, J S, Loeffler
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Current Treatment Options in Neurology, 2008
Metastatic brain tumors are the most common intracranial neoplasm in adults, affecting up to 10% of adults with cancer in the United States. The risk of developing brain metastases varies by primary cancer type, with lung cancer, breast cancer, and melanoma accounting for the majority.
April F, Eichler, Scott R, Plotkin
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Metastatic brain tumors are the most common intracranial neoplasm in adults, affecting up to 10% of adults with cancer in the United States. The risk of developing brain metastases varies by primary cancer type, with lung cancer, breast cancer, and melanoma accounting for the majority.
April F, Eichler, Scott R, Plotkin
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