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Journal of Clinical Oncology, 2006
Brain metastases are the most common brain tumors seen in clinical practice, comprising well over half of all brain tumors. For many years, surgical resection of brain metastases was considered a form of palliative therapy only, but more recently it has been shown to have a more important role in extending survival in appropriately selected patients ...
Michael A, Vogelbaum, John H, Suh
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Brain metastases are the most common brain tumors seen in clinical practice, comprising well over half of all brain tumors. For many years, surgical resection of brain metastases was considered a form of palliative therapy only, but more recently it has been shown to have a more important role in extending survival in appropriately selected patients ...
Michael A, Vogelbaum, John H, Suh
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Radiosurgery for Brain Metastases
Neurosurgery Clinics of North America, 1999Brain metastases represent the most common intracranial neoplasm, and they have become the most common indication for radiosurgery. The authors present a review summarizing the major issues surrounding the management of brain metastases and an English-language literature review of 21 independent reports, using either Gamma Knife or linear accelerator ...
T S, Boyd, M P, Mehta
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Distribution of Brain Metastases
Archives of Neurology, 1988The number and site of brain metastases were identified on the computed tomographic scans of 288 patients. There was one brain metastasis in 49%, two in 21%, three in 13%, four in 6%, and five or more in 11% of scans. In patients with one metastasis, the posterior fossa was involved in 50% of patients when the primary tumor was pelvic (prostate or ...
J Y, Delattre +3 more
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Management of brain metastases
Journal of Neurology, 2002Brain metastases occur in 20-40% of patients with cancer and their frequency has increased over time. Lung, breast and skin (melanoma) are the commonest sources of brain metastases, and in up to 15% of patients the primary site remains unknown. After the introduction of MRI, multiple lesions have outnumbered single lesions. Contrast-enhanced MRI is the
Riccardo, Soffietti +2 more
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Chemoprevention for Brain Metastases
Current Oncology Reports, 2011With the advent of effective therapies for systemic disease control, the prevalence of brain metastases (BMs) has been increasing. Relapses in the brain are a major barrier to cure in many patients with lung cancer and other malignancies. Effective agents are needed to prophylactically treat micrometastatic disease in patients at high risk for BMs ...
Van A, Trinh, Wen-Jen, Hwu
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Brain metastases reirradiation
Cancer/RadiothérapieThe advances in cancer screening and therapies have allowed the improvement of metastatic patients' survival, including those with brain metastases. This led to a substantial shift in brain metastases patients' management for whom whole-brain radiation therapy, formerly widely used, has given way to a more focused management in which single- or ...
Claire, Petit, Agnès, Tallet
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Radiosurgery for Brain Metastases
Clinical Oncology, 2002Brain metastases are a common manifestation of disseminated malignancy and the approach to management has for many years consisted of corticosteroids and brain irradiation [1]. Following palliative whole brain radiotherapy, median survival is in the region of 4 months [2–4] and is dependent on performance status, age and the activity of disease outside
Michael, Brada, Tina, Foord
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The management of brain metastases
Cancer Treatment Reviews, 2003Brain metastases are neoplasms that originate in tissues outside the brain and then spread secondarily to the brain. Metastases to the brain are the most common intracranial tumours in adults. Substantial progress has been made in the treatment of these tumours, and radiotherapy, surgery, and stereotactic radiosurgery are now established treatments ...
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Management of Brain Metastases
Current Treatment Options in Neurology, 2010As systemic cancer therapies have improved, the natural history and importance of treating brain metastases continues to evolve. Historically, most patients with brain metastases have been managed with whole brain radiation therapy (WBRT) with surgical resection or radiosurgery added for patients with single or few metastases.
John G, Stewart +4 more
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Radiosurgery for Brain Metastases
2012We discuss the current literature on the role of stereotactic radiosurgery in the multidisciplinary management of brain metastases and focus on the level of evidence that addresses key management questions. We reviewed the literature on the different roles of radiosurgery, radiotherapy, and resection, and in particular the 2009 Guidelines project of ...
Douglas, Kondziolka +2 more
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