Results 121 to 130 of about 4,226 (251)

The burden of COVID‐19 in hospitalized people with diabetes mellitus in Brazil: Insights from four years of the pandemic

Diabetic Medicine, EarlyView.
Abstract Aims Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is more severe in people with diabetes mellitus due to immune dysfunction, exacerbated inflammation and increased risk of co‐morbidities and mortality.
Taís Mendes Camargo, Bianca Aparecida Siqueira, Luiz Felipe Azevedo Marques, Lucas Silva Mello, Fernando Augusto Lima Marson   +4 more
wiley   +1 more source

Circadian rhythms of metabolite abundance in Drosophila are largely driven by time of feeding

The FEBS Journal, EarlyView.
Circadian clocks exist in the brain and peripheral tissues such as the Drosophila fat body. Single‐nuclei transcriptomics reveal that the fat body clock generates time‐of‐day differences in metabolic gene transcription, which may also be indirectly controlled by brain clocks.
Sumit Saurabh, Charlene Y. P. Guerrero, Madelyn R. Cusick, Amanda J. Samaras, Taylor M. Stephenson, Sebastian L. Kirkpatrick, Gregory J. Matthews, Daniel J. Cavanaugh   +7 more
wiley   +1 more source

A comparative analysis of cell death signalling in RNA and DNA virus infections and potential inhibitory strategies

The FEBS Journal, EarlyView.
RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas, Maria Pitou, Amalia Aggeli, Sotiris Varlamis, Theodora Choli‐Papadopoulou   +4 more
wiley   +1 more source

The molecular basis of GshT substrate binding reveals how Streptococcus pneumoniae acquires the antioxidant glutathione

The FEBS Journal, EarlyView.
Streptococcus pneumoniae imports glutathione (GSH) from its obligate human host to defend against oxidative stress. GSH import is facilitated through the substrate binding protein (SBP) GshT, relying on charge complementarity between the protein and ligand.
Sarah E. du Toit, Paul E. Pace, Pierre De Cordovez, Christoph Göbl, Nina Dickerhof   +4 more
wiley   +1 more source

TIM‐3 Functions as an Activator of NK Cells in GBM and Can Be Upregulated by Torin‐1: Implications for Exogenous NK Cell Transplantation

Immunology, EarlyView.
Unlike generalized mTOR inhibitors, Torin‐1 uniquely drives compensatory upregulation of TIM‐3 on human NK cells, shielding them from immunosuppression while concurrently inhibiting glioblastoma (GBM) growth. Selecting or preconditioning ex vivo NK cell products for high TIM‐3 expression can offer a combination strategy for adoptive cell therapy in GBM.
Yuning Liu, Tram Dao, Shambhavi Borde, Diana Dinh, Sofia Lombardi, Sandra Torregrosa‐Allen, Haley A. Harper, Veronika Slivova, Aaron Cohen‐Gadol, MacKenzie McIntosh, Bennet D. Elzey, Sandro Matosevic   +11 more
wiley   +1 more source

STORM: spatial transcriptomics optimization by resolution via matrix factorization. [PDF]

Brief Bioinform
Gurarslan D, Camargo O, Zeyveli O, Almalioglu Y, Li Y, Turan M, Kahveci T.   +6 more
europepmc   +1 more source

Immunomodulatory Peptide LW‐9 Enhances Doxorubicin Efficacy by Downregulating PD‐L1 and Promoting Intratumoral T‐Cell Responses in Murine Breast Cancer

Immunology, EarlyView.
LW‐9, a peptide derived from Phoneutria nigriventer venom, enhances antitumor immunity in a murine breast cancer model by remodelling the tumour microenvironment. Treatment reduces PD‐L1 expression while increasing CD3+ and GITR+ T‐cell infiltration, resulting in delayed tumour progression, particularly when combined with doxorubicin.
Ingrid Mayara Cavalcante Trevisan, Cibele Pereira Mariano, Sabrina Carvalho Brunelli, Gabriel da Silva Cordeiro, Jessika Takaki, Valquiria Aparecida Matheus, Liana Verinaud, Catarina Rapôso   +7 more
wiley   +1 more source

Tachycardia As Therapy: Control of an Electrical Storm Through Mechanism-Directed Treatment After Refractory Ventricular Arrhythmias. [PDF]

Cureus
Santos M, Albuquerque A, Dias G, Henriques F, Gomes O.   +4 more
europepmc   +1 more source