Results 1 to 10 of about 367,590 (144)

Brain Tumors [PDF]

Seminars in Nuclear Medicine, 2012
This review addresses the specific contributions of nuclear medicine techniques, and especially positron emission tomography (PET), for diagnosis and management of brain tumors. (18)F-Fluorodeoxyglucose PET has particular strengths in predicting prognosis and differentiating cerebral lymphoma from nonmalignant lesions.
Herholz, Karl, Langen, Karl Josef, Schiepers, Christiaan, Mountz, James M.   +3 more
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Brain tumors [PDF]

CA: A Cancer Journal for Clinicians, 1993
Brain tumors are a relatively common cancer in all age groups, and the incidence of both primary and metastatic brain tumors is increasing. Fortunately, dramatic advances in methods of diagnosis, surgical technique, and adjuvant therapy have all contributed to an improved outlook for patients with brain tumors.
E R, Laws, K, Thapar
openaire   +4 more sources

Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma

Nature Communications, 2023
Senescence can have beneficial and detrimental impact on cancer progression depending on the cellular context. Here the authors show that NRF2 regulates the senescence phenotype in malignant cells which consequently contribute to glioblastoma progression.
Rana Salam, Alexa Saliou, Franck Bielle, Mathilde Bertrand, Christophe Antoniewski, Catherine Carpentier, Agusti Alentorn, Laurent Capelle, Marc Sanson, Emmanuelle Huillard, Léa Bellenger, Justine Guégan, Isabelle Le Roux   +12 more
doaj   +1 more source

VRK3 depletion induces cell cycle arrest and metabolic reprogramming of pontine diffuse midline glioma - H3K27 altered cells

Frontiers in Oncology, 2023
We previously identified VRK3 as a specific vulnerability in DMG-H3K27M cells in a synthetic lethality screen targeting the whole kinome. The aim of the present study was to elucidate the mechanisms by which VRK3 depletion impact DMG-H3K27M cell fitness.
Virginie Menez, Thomas Kergrohen, Tal Shasha, Claudia Silva-Evangelista, Ludivine Le Dret, Lucie Auffret, Chloé Subecz, Manon Lancien, Yassine Ajlil, Irma Segoviano Vilchis, Kévin Beccaria, Kévin Beccaria, Thomas Blauwblomme, Estelle Oberlin, Jacques Grill, Jacques Grill, David Castel, Marie-Anne Debily, Marie-Anne Debily   +18 more
doaj   +1 more source

Novel insight into histological and molecular astrocytoma, IDH‐mutant, Grade 4 by the updated WHO classification of central nervous system tumors

Cancer Medicine, 2023
Background The latest fifth edition of the World Health Organization (WHO) classification of the central nervous system (CNS) tumors (WHO CNS 5 classification) released in 2021 defined astrocytoma, IDH‐mutant, Grade 4.
Wenlin Chen, Siying Guo, Yaning Wang, Yixin Shi, Xiaopeng Guo, Delin Liu, Yilin Li, Yuekun Wang, Hao Xing, Yu Xia, Junlin Li, Jiaming Wu, Tingyu Liang, Hai Wang, Qianshu Liu, Shanmu Jin, Tian Qu, Huanzhang Li, Tianrui Yang, Kun Zhang, Yu Wang, Wenbin Ma   +21 more
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The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest

Cell Death and Disease, 2023
Glioblastoma multiforme (GBM) is the most lethal primary brain tumor with a poor median survival of less than 15 months. However, clinical strategies and effective therapies are limited.
Wenpeng Zhao, Liang Zhang, Yaya Zhang, Zhengye Jiang, Hanwen Lu, Yuanyuan Xie, Wanhong Han, Wentao Zhao, Jiawei He, Zhongjie Shi, Huiying Yang, Junjie Chen, Sifang Chen, Zhangyu Li, Jianyao Mao, Liwei Zhou, Xin Gao, Wenhua Li, Guowei Tan, Bingchang Zhang, Zhanxiang Wang   +20 more
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An online survival predictor in glioma patients using machine learning based on WHO CNS5 data

Frontiers in Neurology, 2023
BackgroundThe World Health Organization (WHO) CNS5 classification system highlights the significance of molecular biomarkers in providing meaningful prognostic and therapeutic information for gliomas.
Liguo Ye, Lingui Gu, Zhiyao Zheng, Zhiyao Zheng, Zhiyao Zheng, Xin Zhang, Hao Xing, Xiaopeng Guo, Xiaopeng Guo, Wenlin Chen, Yaning Wang, Yuekun Wang, Tingyu Liang, Hai Wang, Yilin Li, Yilin Li, Shanmu Jin, Shanmu Jin, Yixin Shi, Yixin Shi, Delin Liu, Delin Liu, Tianrui Yang, Tianrui Yang, Qianshu Liu, Qianshu Liu, Congcong Deng, Yu Wang, Yu Wang, Wenbin Ma, Wenbin Ma   +30 more
doaj   +1 more source

Prognostic Value of Choline and Other Metabolites Measured Using ¹H-Magnetic Resonance Spectroscopy in Gliomas: A Meta-Analysis and Systemic Review

Metabolites, 2022
Glioma is the most prevalent primary central nervous system malignant tumor, with high heterogeneity observed among different grades; therefore, non-invasive prediction of prognosis could improve the clinical management of patients with glioma.
Yixin Shi, Delin Liu, Ziren Kong, Qianshu Liu, Hao Xing, Yuekun Wang, Yu Wang, Wenbin Ma   +7 more
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Revisiting the Immunological Aspects of Temozolomide Considering the Genetic Landscape and the Immune Microenvironment Composition of Glioblastoma

Frontiers in Oncology, 2021
The microenvironment (ME) plays a critical role in causing glioblastoma (GBM) to be a moving and incurable target. The main features governing the interaction between cancer cells and the ME include dependency, promotion, and in rare cases, even ...
Natalia Di Ianni, Natalia Di Ianni, Martina Maffezzini, Martina Maffezzini, Marica Eoli, Serena Pellegatta, Serena Pellegatta   +6 more
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Characteristic analysis and identification of novel molecular biomarkers in elderly glioblastoma patients using the 2021 WHO Classification of Central Nervous System Tumors

Frontiers in Neuroscience, 2023
IntroductionElderly glioblastoma (GBM) patients is characterized by high incidence and poor prognosis. Currently, however, there is still a lack of adequate molecular characterization of elderly GBM patients.
Yaning Wang, Junlin Li, Junlin Li, Yaning Cao, Yaning Cao, Wenlin Chen, Hao Xing, Xiaopeng Guo, Xiaopeng Guo, Yixin Shi, Yixin Shi, Yuekun Wang, Tingyu Liang, Liguo Ye, Delin Liu, Delin Liu, Tianrui Yang, Tianrui Yang, Yu Wang, Yu Wang, Wenbin Ma, Wenbin Ma   +21 more
doaj   +1 more source