Results 61 to 70 of about 6,149,012 (253)

Microglia-derived microvesicles affect microglia phenotype in glioma [PDF]

, 2019
Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring a ready to use box of information, consisting of proteins, lipids and nucleic acids.
Alfonso Grimaldi, Angelo Sarra, Barbara Ruzicka, Carmela Serpe, Cristina Limatola, Cristina Limatola, Francesca Guerrieri, Giancarlo Ruocco, Giuseppe Familiari, Giuseppe Rubens Pascucci, Giuseppina Chece, Michela Relucenti, Myriam Catalano, Myriam Catalano, Valentina Nigro   +14 more
core   +5 more sources

Clinical features, MRI, molecular alternations, and prognosis of astrocytoma based on WHO 2021 classification of central nervous system tumors: A single‐center retrospective study

Cancer Medicine
Background The diagnosis of glioma has advanced since the release of the WHO 2021 classification with more molecular alterations involved in the integrated diagnostic pathways.
Yuekun Wang, Hao Xing, Xiaopeng Guo, Wenlin Chen, Yaning Wang, Tingyu Liang, Hai Wang, Yilin Li, Shanmu Jin, Yixin Shi, Delin Liu, Tianrui Yang, Yu Xia, Junlin Li, Jiaming Wu, Qianshu Liu, Tian Qu, Siying Guo, Huanzhang Li, Kun Zhang, Yu Wang, Wenbin Ma   +21 more
doaj   +1 more source

The role of the immune system in brain metastasis [PDF]

, 2019
Metastatic brain tumors are the most common brain tumors in adults. With numerous successful advancements in systemic treatment of most common cancer types, brain metastasis is becoming increasingly important in the overall prognosis of cancer patients ...
Dey, Mahua, Leibold, Adam T., Monaco, Gina N.   +2 more
core  

Stalled developmental programs at the root of pediatric brain tumors

Nature Genetics, 2019
Childhood brain tumors have suspected prenatal origins. To identify vulnerable developmental states, we generated a single-cell transcriptome atlas of >65,000 cells from embryonal pons and forebrain, two major tumor locations.
Selin Jessa, A. Blanchet-Cohen, Brian Krug, Maria C. Vladoiu, Marie Coutelier, D. Faury, B. Poreau, Nicolas de Jay, S. Hébert, Jean Monlong, W. T. Farmer, Laura K. Donovan, Yixing Hu, M. McConechy, F. Cavalli, Leonie G. Mikael, B. Ellezam, M. Richer, A. Allaire, Alexander G. Weil, J. Atkinson, J. Farmer, Roy W. R. Dudley, Valérie Larouche, L. Crevier, S. Albrecht, M. Filbin, H. Sartelet, P. Lutz, Corina Nagy, G. Turecki, S. Costantino, P. Dirks, Keith K. Murai, G. Bourque, J. Ragoussis, L. Garzia, Michael D. Taylor, N. Jabado, C. Kleinman   +39 more
semanticscholar   +1 more source

Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas

Nature Communications, 2023
Temozolomide (TMZ) is a standard treatment for glioblastoma (GBM) patients. However, TMZ has moderate therapeutic effects due to chemoresistance of GBM cells through less clarified mechanisms.
Jianxing Yin, Xiefeng Wang, Xin Ge, Fangshu Ding, Zhumei Shi, Zehe Ge, Guang Huang, Ningwei Zhao, Dongyin Chen, Junxia Zhang, Sameer Agnihotri, Yuandong Cao, Jing Ji, Fan Lin, Qianghu Wang, Qigang Zhou, Xiuxing Wang, Yongping You, Zhimin Lu, Xu Qian   +19 more
doaj   +1 more source

Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements. [PDF]

, 2009
The biology of both normal and tumor development clearly possesses overlapping and parallel features. Oncogenes and tumor suppressors are relevant not only in tumor biology, but also in physiological developmental regulators of growth and differentiation.
Ho, Allen L, Hughes, Samuel, Jandial, Rahul, Levy, Michael L, Menon, Jayant   +4 more
core   +3 more sources

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson, Adams, Aicher, Armulik, Arosarena, Augustin, Benedito, Bergers, Blouw, Brastianos, Cancer Genome Atlas Research Network, Carmeliet, Cathrin J. Czupalla, Cattelino, Chien, Claxton, Corada, Daneman, Daneman, Devraj, Ernesto Bockamp, Estrach, Fisher, Franco, Gerhardt, Gerhardt, Harada, Harrington, Hellström, Jadranka Macas, Jakobsson, Jenny Zinke, Kamino, Karl H. Plate, Kavi Devraj, Kotliarova, Li, Liebner, Liebner, Liebner, Liebner, Lobov, Lobov, Lucero, Machein, Mailhos, Makoto M. Taketo, Marco Reis, Marcus Fruttiger, McCarty, Min, Nicole Ziegler, Noguera-Troise, Olsson, Phng, Phng, Rosario Heck, Saharinen, Sascha Seidel, Schneider, Segarra, Siekmann, Smadja, Smolich, Sonja Thom, Stefan Liebner, Stefanie Dimmeler, Stenman, Streit, Thomas, Vleminckx, Willert, Williams, Wolburg, Yano, Yano, Yoshio-Hoshino, Zhang, Zhang, Zhou   +79 more
core   +1 more source

Risk Factors For Childhood And Adult Primary Brain Tumors.

Neuro-Oncology, 2019
Primary brain tumors account for ~1% of new cancer cases and ~2% of cancer deaths in the United States; however, they are the most commonly occurring solid tumor in children.
Q. Ostrom, M. A. Fahmideh, D. Cote, I. Muskens, Jeremy M. Schraw, M. Scheurer, M. Bondy   +6 more
semanticscholar   +1 more source

Uranyl phthalocyanines show promise in the treatment of brain tumors [PDF]

, 1967
Processes synthesize sulfonated and nonsulfonated uranyl phthalocyanines for application in neutron therapy of brain tumors.
Frigerio, N. A.
core   +1 more source

Efficacy of Combined 5-Fluorouracil and Photodynamic Therapy in Glioma Spheroids

, 2018
Standard treatment regimens consisting of surgery, radiation and chemotherapy have proven ineffective for the treatment of high-grade gliomas such as glioblastoma multiforme (GBM).
Singh, Karanjit
core   +1 more source