Results 61 to 70 of about 633,673 (286)

TERTp Mutation and its Prognostic Value in Glioma Patients Under the 2021 WHO Classification: A Real‐World Study

Cancer Medicine
Background The 2021 WHO Classification of Central Nervous System Tumors introduces more molecular markers for glioma reclassification, including TERT promoter (TERTp) mutation as a key feature in glioblastoma diagnosis.
Hao Xing, Delin Liu, Junlin Li, Yulu Ge, Xiaopeng Guo, Wenlin Chen, Dachun Zhao, Yixin Shi, Yilin Li, Yaning Wang, Yuekun Wang, Yu Xia, Jiaming Wu, Tingyu Liang, Hai Wang, Qianshu Liu, Shanmu Jin, Tian Qu, Siying Guo, Huanzhang Li, Tianrui Yang, Kun Zhang, Yu Wang, Wenbin Ma   +23 more
doaj   +1 more source

USP25 deubiquitinates cytosolic METTL3 to impede glioma proliferation via an m6A-independent pathway

iScience
Summary: METTL3 exhibits distinct tumorigenic roles in the nucleus and cytoplasm, but whether its post-transcriptional modifications vary by subcellular localization remains unclear.
Bingchang Zhang, Wanhong Han, Xin Gao, Wenhua Li, Jianhua Yu, Wujie Zhao, Jiawei He, Xiansheng Qiu, Zhenwei Lu, Liwei Zhou, Yahui Hu, Yuanyuan Xie, Yanyan Geng, Hanwen Lu, Wentao Zhao, Xinwen Liao, Shouren Chen, Xiyao Liu, Sifang Chen, Guowei Tan, Yaya Zhang, Zhanxiang Wang   +21 more
doaj   +1 more source

Epigenomics and immunotherapeutic advances in pediatric brain tumors

npj Precision Oncology, 2021
Brain tumors are the leading cause of childhood cancer-related deaths. Similar to adult brain tumors, pediatric brain tumors are classified based on histopathological evaluations. However, pediatric brain tumors are often histologically inconsistent with
Malak Abedalthagafi, Nahla Mobark, May Al-Rashed, Musa AlHarbi   +3 more
doaj   +1 more source

Brain Tumor Vaccines

Neurosurgery Clinics of North America, 2021
Peptide and dendritic cell vaccines activate the immune system against tumor antigens to combat brain tumors. Vaccines stimulate a systemic immune response by inducing both antitumor T cells as well as humoral immunity through antibody production to cross the blood-brain barrier and combat brain tumors.
Lee, Justin, Uy, Benjamin R, Liau, Linda M   +2 more
openaire   +4 more sources

Protein kinase a distribution differentiates human glioblastoma from brain tissue [PDF]

, 2017
Brain tumor glioblastoma has no clear molecular signature and there is no effective therapy. In rodents, the intracellular distribution of the cyclic AMP (cAMP)-dependent protein kinase (Protein kinase A, PKA) R2Alpha subunit was previously shown to ...
Caretta, Antonio, D\u2019Avella, Domenico, Denaro, Luca, Mucignat-Caretta, Carla   +3 more
core   +2 more sources

Exercise Interventions in Children, Adolescents and Young Adults With Paediatric Bone Tumours—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser, Claire Laurie, Teresa Schmidt, Irene von Luettichau, Peter Bekkering, Sabine Kesting   +5 more
wiley   +1 more source

The combination of temozolomide and perifosine synergistically inhibit glioblastoma by impeding DNA repair and inducing apoptosis

Cell Death Discovery
Temozolomide (TMZ) is widely utilized as the primary chemotherapeutic intervention for glioblastoma. However, the clinical use of TMZ is limited by its various side effects and resistance to chemotherapy.
Wenpeng Zhao, Liwei Zhou, Wentao Zhao, Huiying Yang, Zhenwei Lu, Liang Zhang, Yaya Zhang, Yuanyuan Xie, Hanwen Lu, Wanhong Han, Jiawei He, Xiansheng Qiu, Fang Jia, Wujie Zhao, Bingchang Zhang, Zhanxiang Wang   +15 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Artificial neural network identified a 20‐gene panel in predicting immunotherapy response and survival benefits after anti‐PD1/PD‐L1 treatment in glioblastoma patients

Cancer Medicine
Background Immune checkpoint inhibitors (ICIs) are a promising immunotherapy approach, but glioblastoma clinical trials have not yielded satisfactory results. Objective To screen glioblastoma patients who may benefit from immunotherapy.
Yaning Wang, Zihao Wang, Xiaopeng Guo, Yaning Cao, Hao Xing, Yuekun Wang, Bing Xing, Yu Wang, Yong Yao, Wenbin Ma   +9 more
doaj   +1 more source

Visual hallucinations in neurosurgery: A systematic review and two case insights into Charles Bonnet Syndrome

Brain and Spine
Introduction: Visual disturbances in brain tumor patients occur as a direct consequence of tumor location or as a complication after surgery. These can range from minor vision changes to severe impairments, including visual hallucinations.
Erica Grasso, Giulio Bonomo, Francesco Certo, Giacomo Cammarata, Giuseppe M.V. Barbagallo   +4 more
doaj   +1 more source