Results 101 to 110 of about 761,048 (226)

Gene therapy for hereditary deafness: Progress, challenges and translational implications from OTOF to GJB2

open access: yesClinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Current Management & Limitations: Traditional auditory devices lack genetic curative potential and yield variable, non‐physiological hearing outcomes. OTOF gene therapy has shown promising clinical outcomes with dual‐AAV therapy. GJB2 gene therapy remains an emerging approach with significant translational challenges. Advances in vector design and cell‐
Jiahui Zhao, Mengzhao Xun, Yu Sun
wiley   +1 more source

Test–Retest Reliability of Dual-Recorded Brainstem versus Cortical Auditory-Evoked Potentials to Speech

open access: yes, 2018
Auditory-evoked potentials have proven useful in the objective evaluation of sound encoding at different stages of the auditory pathway (brainstem and cortex).
Pousson, Monique   +7 more
core   +1 more source

Developmental Trajectory of Auditory Brainstem Deficits in a Mouse Model of Fetal Alcohol Spectrum Disorders

open access: yesDevelopmental Neurobiology, Volume 86, Issue 4, October 2026.
ABSTRACT Individuals with fetal alcohol spectrum disorders exhibit impaired auditory processing and atypical auditory behaviors across the disorder's spectrum. Although low to moderate prenatal alcohol exposure (PAE) is a prevalent type of exposure, the developmental trajectory of auditory processing deficits resulting from this level of exposure ...
Michael Douchey   +3 more
wiley   +1 more source

Small Molecule Therapeutic Approaches With a Greater Focus on Hearing Loss: A Review

open access: yesHealth Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Hearing loss (HL) is one of the most common sensory impairments worldwide and has substantial effects on quality of life and daily functioning. Although cochlear implants and hearing aids have markedly improved the management of hearing impairment, these devices do not directly address the underlying pathogenic mechanisms ...
Maryam Naghinejad   +5 more
wiley   +1 more source

Herbal Formula AC591 Protects Against Cisplatin‐Induced Hearing Loss by Inhibiting p53‐Mediated Ferroptosis

open access: yesSmart Medicine, Volume 5, Issue 5, October 2026.
AC591 and its core active component 18β‐glycyrrhetinic acid effectively alleviate cisplatin‐induced ototoxicity by binding p53 and suppressing p53‐mediated ferroptosis, representing promising agents for preventing cisplatin‐related hearing loss. ABSTRACT Cisplatin is a widely utilized chemotherapeutic agent for the treatment of malignant cancers ...
Yunhao Wu   +9 more
wiley   +1 more source

IGF‐1/SLC25A33 Maintains Blood‐Labyrinth Barrier Integrity by Suppressing TGF‐β/Smad2‐Mediated Pericyte Activation in Age‐Related Hearing Loss

open access: yesAging Cell, Volume 25, Issue 10, October 2026.
IGF‐1/SLC25A33–TGF‐β/Smad2 axis can regulate pericyte activation and BLB integrity, which may be a potential therapeutic target for preserving hearing in ARHL. ABSTRACT Age‐related hearing loss (ARHL) is a prevalent sensory disorder in the elderly, yet the molecular mechanisms underlying cochlear aging remain incompletely understood. While insulin‐like
Rui Xu   +9 more
wiley   +1 more source

Brainstem auditory evoked potentials in patients with primary Sjögren's syndrome without central nervous system involvement. [PDF]

open access: yesClin Rheumatol, 2021
Waliszewska-Prosół M   +5 more
europepmc   +1 more source

Emergence of Deviance Detection in Cortical Cultures Through Maturation, Criticality, and Early Experience

open access: yesEuropean Journal of Neuroscience, Volume 64, Issue 7, October 2026.
Deviance detection (DD) emerges in dissociated cortical cultures around DIV15 and remains detectable through maturation. Near‐critical network dynamics are associated with stronger DD responses. Early structured stimulation was associated with descriptive differences in response timing and DD strength, although mature‐stage group differences were not ...
Zhuo D. Zhang   +5 more
wiley   +1 more source

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