Results 61 to 70 of about 29,519 (246)
A Thermo-Mechanical Stress Based Fatigue Life Evaluation of a Mine Hoist Drum Brake System Using COMSOL Multiphysics. [PDF]
Materials (Basel), 2022 Radu SM +5 more
europepmc +1 more source
Advanced Science, EarlyView.This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang +7 more
wiley +1 more source
PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury
Advanced Science, EarlyView.Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu +11 more
wiley +1 more source
Research of Adding Parking Brake in CRH2 EMUs
机车电传动, 2016 According to the characteristics of parking brake and CRH2 EMUs brake system, a design scheme and pipe gram and electric control circuits used for parking brake in CRH2 was proposed , and the theoretical calculation was done.
SU Chao, GAO Qi
doaj
Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Advanced Science, EarlyView.Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source
Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Advanced Science, EarlyView.Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source
A Practical Approach for On-Road Measurements of Brake Wear Particles from a Light-Duty Vehicle
AtmosphereBrake wear particles are generated through frictional contact between the brake disc or brake drum and the brake pads. Some of these particles may be released into the atmosphere, contributing to airborne fine particulate matter (PM2.5).
Jon Andersson +7 more
doaj +1 more source
Advanced Science, EarlyView.Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao +3 more
wiley +1 more source
DESIGN FOR WET BRAKE OF AUTOMOBILE BASED ON THE REAL TIME TEMPERATURE CONTROL SYSTEM
Jixie qiangdu, 2016 In order to solve the problems of much heat during braking process,and poor stability in high speed condition of the automobile wet brake,a new type of wet brake based on the layout of real time temperature control was proposed by analyzing the working ...
PANG JingLi
doaj
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source