Results 111 to 120 of about 111,957 (308)

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

The Evaluation of Braking Performances of Mechanical Brake System on Oil Rig

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2013
This paper proposes a novel method for evaluating the braking system on oil rig. The Evaluation indexes, braking capacity, response speed control accuracy and braking efficiency, are put forward according to the drilling safety, benefit, quality and so ...
Yu WANG, Li LIN
doaj   +1 more source

Reduced magnetic braking and the magnetic capture model for the formation of ultra-compact binaries

, 2005
A binary in which a slightly evolved star starts mass transfer to a neutron star can evolve towards ultra-short orbital periods under the influence of magnetic braking. This is called magnetic capture.
Alexander, Andronov, Böhm-Vitense, Chou, Eggleton, Eggleton, Eggleton, F. Verbunt, Iglesias, Ivanova, Kawaler, King, Krishnamurthi, M. V. van der Sluys, Mochnacki, O. R. Pols, Peters, Podsiadlowski, Pols, Rappaport, Sills, Skumanich, Stepien, Terndrup, Van der Klis, Van der Klis, Van der Sluys, Verbunt, Verbunt, Vilhu, Vilhu   +30 more
core   +1 more source

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Behavior of aircraft antiskid breaking systems on dry and wet runway surfaces: A slip-ratio-controlled system with ground speed reference from unbraked nose wheel [PDF]

An experimental investigation was conducted at the Langley aircraft landing loads and traction facility to study the braking and cornering response of a slip ratio controlled aircraft antiskid braking system with ground speed reference derived from an ...
Stubbs, S. M., Tanner, J. A.
core   +1 more source

Statistical mechanics of non-hamiltonian systems: Traffic flow

, 2007
Statistical mechanics of a small system of cars on a single-lane road is developed. The system is not characterized by a Hamiltonian but by a conditional probability of a velocity of a car for the given velocity and distance of the car ahead ...
A Šurda, Behringer H, Fukui M, Gross D H E, Gross D H E, Helbing D, Herman R, Hoogendoorn S P, Krbálek M, Pleimling M Behringer H, Wolf D E   +10 more
core   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

YZ-D Electro-pneumatic Braking System for Super-long-heavy Maintenance Equipment

机车电传动, 2017
Aiming at the drawbacks of YZ-1 pneumatic braking system and YZ-2 electro-pneumatic braking system applied in superlong- heavy maintenance equipment, a novel YZ-D electro-pneumatic braking system was designed.
XU Hongchun
doaj  

Behavior of aircraft antiskid braking systems on dry and wet runway surfaces: Hydromechanically controlled system [PDF]

The investigation utilized one main gear wheel, brake, and tire assembly of a McDonnell Douglas DC-9 series 10 airplane. The landing-gear strut was replaced by a dynamometer.
Smith, E. G., Stubbs, S. M., Tanner, J. A.   +2 more
core   +1 more source

Transcriptomic and Neuroimaging Decoding of Brain‐Immune Crosstalk in Thyroid Eye Disease

Advanced Science, EarlyView.
This study employed an imaging transcriptomics framework integrating resting‐state fMRI with Allen Human Brain Atlas transcriptomic data, coupled with peripheral blood RNA sequencing, to decode brain‐immune crosstalk in thyroid eye disease. Frontal, parietal, subcortical, and brainstem regions were identified as key neuroimmune‐ vulnerable regions ...
Haiyang Zhang, Yuting Liu, Shufan Jiang, Zilin Fang, Mengda Jiang, Xiaofeng Tao, Tianyi Zhu, Jipeng Li, Sijie Fang, Xuefei Song, Yinwei Li, Jing Sun, Chuanjun Tong, Zhengrun Gao, Huifang Zhou, Xianqun Fan   +15 more
wiley   +1 more source