Results 71 to 80 of about 14,097 (243)
Location-Routing Problem of Emergency Facilities under Uncertain Demand by Branch-Price and Cut
Journal of Mathematics, 2021 This paper studies the location-routing problem of emergency facilities with time window under demand uncertainty. We propose a robust mathematical model in which uncertain requirements are represented by two forms: the support set defined by cardinal ...
Xuchen Deng
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
El algoritmo Branch and Cut en programación lineal entera [PDF]
, 2023 Los problemas de programación lineal entera aparecen en numerosas ocasiones modelando situaciones del mundo real donde las variables de decisión deben tomar valores enteros.
Noriega González, Carlos
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Metode Branch and Cut untuk Menyelesaikan Multi-Objective Integer Programming
, 2014 BRANCH AND CUT METHOD FOR SOLVING MULTI OBJECTIVE INTEGER PROGRAMMING ABSTRACT Branch and Cut method is a kind of technique for solving linear programming problem which expect integer for its decision variable, but it usually use to solve a ...
Amalia, Rizkika
core
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Applied SciencesIn panel-furniture manufacturing, dynamic scheduling is challenging because upstream motherboard release and parallel CUT-machine assignment are tightly coupled with downstream multibranch processing, finite-capacity buffers, and machine disturbances ...
Yajun Zhang +4 more
doaj +1 more source
Branch and cut based on the volume algorithm : Steiner trees in graphs and max-cut [PDF]
, 2006 We present a Branch-and-Cut algorithm where the volume algorithm is applied instead of the traditionally used dual simplex algorithm to the linear programming relaxations in the root node of the search tree.
Barahona, Francisco +3 more
core +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source