Results 41 to 50 of about 1,705,148 (239)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Fruitless Branch and the Eternal Security of the Believer

E-Journal of Religious and Theological Studies, 2022
The quest for the identification of the fruitless branch has been an enduring theological battleground between the Calvinists and the Arminians who argue as to whether or not the removal of the fruitless branch indicates the loss of eternal salvation.
Anthony Yaw Badu, Jonathan E.T. Kuwornu-Adjaottor   +1 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Exploiting planarity in separation routines for the symmetric traveling salesman problem [PDF]

, 2008
At present, the most successful approach for solving large-scale instances of the Symmetric Traveling Salesman Problem to optimality is branch-and-cut.
Adam N. Letchford, Nicholas A. Pearson, Pearson, N, Letchford, Adam N., Letchford, A N, Pearson, Nicholas A.   +5 more
core   +1 more source

Multi-objective Optimization of Peak Cutting Force and Cutting Energy Consumption in Cutting of Caragana korshinskii Branches

BioResources, 2022
Caragana korshinskii (C.K.) flat stubble residue is an abundant biomass energy source in China. Because branch cutting is closely related to the harvesting of forest biomass, it is practical for forestry production and ecological development to ...
Yaoyao Gao, Xiaoya Hu, Siyuan Tong, Jiangming Kan, Yutan Wang, Feng Kang   +5 more
doaj   +2 more sources

PENERAPAN BRANCH AND BOUND ALGORITHM DALAM OPTIMALISASI PRODUKSI ROTI

E-Jurnal Matematika, 2016
Companies which engaged in production activities such as Ramadhan Bakery would want optimal profit in their every production. The aim of this study was to find optimal profit and optimal combination of bread production (original chocolate bread, extra ...
GEDE SURYAWAN, NI KETUT TARI TASTRAWATI, KARTIKA SARI   +2 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Leaf Pruning End-Effector for Adaptive Positioning at the Branch–Stem Junction of Tomato Plants

Agriculture
To address the needs of mechanized tomato leaf pruning, this paper presents the design of an end-effector capable of adaptive positioning at the base of the branch.
Yuhuan Sun, Wenqiao Lu, Qingchun Feng, Liang He, Hongda Diao, Yuhang Ma, Liping Chen   +6 more
doaj   +1 more source

Technology of double casing tubes & a binary cycle system for hole cleaning for CBM multi-branch horizontal wells

Natural Gas Industry B, 2017
At present, the aeration-assisted cutting-carrying technology is faced with complexities in the drilling of CBM multi-branch horizontal wells. For example, the aerating pressure is hardly maintained, and the borehole instability may happen.
Yong Yang, Shuqing Cui, Fengrui Wang, Bin Zhang, Yuanyong Ni, Jiaxun Shen, Zhenxuan Li, Shuping Liu   +7 more
doaj   +1 more source