Results 101 to 110 of about 80,674 (255)

Role of Epoxide Functionalization of Amines for Development of Direct Air Capture Sorbents with High Cyclic Working Capacity at Low Desorption Temperatures

Advanced Science, EarlyView.
Appropriate butylene oxide (BO) functionalization of amines (polyethyleneimine (PEI1200 and PEI300) and tris(2‐aminoethyl)amine (TREN)) enables excellent cyclic working capacities (WCcyclic) at low desorption temperatures (40−70°C). Notably, 0.30BO‐PEI300‐SY and 0.54BO‐TREN‐SY show the highest WCcyclic at 45 and 40°C, respectively.
Joo Yeon Han, Hayoung Jeong, Younghyu Ko, Yohan Cho, Seenu Ravi, Kyu‐Min Ryoum, Hyug Hee Han, Yujin Choi, Chaewon Shin, Jeong Woo Han, Youn‐Sang Bae   +10 more
wiley   +1 more source

Cu-doped dendritic biodegradable nanoplatforms for augmenting cuproptosis and tumor-starvation therapy through mitochondrial metabolic cascade modulation

Materials Today Bio
Reprogramming of branched-chain amino acid (BCAA) metabolism is a key mechanism promoting pancreatic cancer progression. While gabapentin (Gp) can inhibit BCAA catabolism by targeting branched-chain amino acid aminotransferase 1 (BCAT1), its efficacy is ...
Han Shi, Zhiqiang Xie, Junrong Zhang, Fengchun Lu, Haoteng Luo, Pengfei Guo, Meichen Jiang, Zongqi Weng, Xin Luo, Bing Chen, Heguang Huang, Tianhong Teng   +11 more
doaj   +1 more source

Advanced Dental Composite Technology via Bisilanized Dual‐Action Nanofillers for Biofilm Control

Advanced Science, EarlyView.
A multimodal research strategy has led to the development of an innovative resin‐based composite (RBC) with dual antibacterial action. The S_CM‐RBC formula showed strong antibiofilm activity, excellent mechanical strength, and biosafety. It effectively controlled oral bacteria in prevention of caries recurrence, and maintained pulp health in a rat ...
Chenmin Yao, Line Etiennot, Naiera Zayed, Shengjie Liang, Mehraveh Saghi, Jelle Verdonck, Lingyue Liu, Fei Zhang, Wim Teughels, Cui Huang, Kirsten Van Landuyt, Bart Van Meerbeek   +11 more
wiley   +1 more source

Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance

Advanced Science, EarlyView.
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes, Xiaokang Jin, Miguel A. Campos, Chen Zhou, Xiaoyu Zhang   +4 more
wiley   +1 more source

Programmable Hydration Pathways Enable Reconfigurable Ionic Thermoelectrics for Energy Harvesting and Thermal‐Tactile Interaction

Advanced Science, EarlyView.
Programmable hydration pathways enable reconfigurable ionic thermoelectrics in polyquaternium hydrogels. By coupling microscopic solvation, mesoscale water channels, and macroscopic boundary control, hydration‐gated protonics decouples thermopower, response speed, and stability.
Zehao Zhao, Yun Shen, Dongyan Xu
wiley   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

Dynamic Self‐Clickable Decellularized Matrix Hydrogels for Regulating Vascularity and Enhancing Muscle Regeneration

Advanced Science, EarlyView.
Dynamic decellularized hydrogels are prepared using bovine decellularized small intestine submucosa (SIS) norbornene (dSIS‐NB). Bovine dSIS contained significant amounts of disulfide‐rich fibrillin‐I, enabling ‘self‐clickable’ thiol‐norbornene gelation and spatiotemporal tuning of hydrogel physicochemical properties.
Van Thuy Duong, Tuba Marjan, Ngoc Ha Luong, Taimoor H. Qazi, Chien‐Chi Lin   +4 more
wiley   +1 more source

Prospective association between plasma amino acids and three Multimorbidity patterns in older adults

Scientific Reports
The role of metabolomic profiling on different multimorbidity patterns remains unknown. This study aims to assess the prospective relationship between plasma concentrations of amino acids and three different multimorbidity patterns: musculoskeletal and ...
Grace Velapatiño-Gamarra, Alberto Lana, Humberto Yévenes-Briones, Juan Cárdenas-Valladolid, José R. Banegas, Fernando Rodríguez-Artalejo, Esther López-García, Francisco Félix Caballero   +7 more
doaj   +1 more source

Janus‐Type Electrostatic Potential Gradient‐Activated Dynamic Zn2+‐Coordinating Nitrogen Sites in Molecularly Locked Nanocellulose Separators for Stable Zinc‐Ion Batteries

Advanced Science, EarlyView.
A multifunctional benzimidazole‐terminated CNF separator is constructed via a PEI‐mediated covalent locking strategy, generating dense zincophilic sites that accelerate Zn2+ transport and desolvation while enabling uniform Zn (002) deposition and suppressing side reactions.
Jie Liang, Shuxin Yang, Shuaiqi Zhao, Haitao Yang, Jingyuan Li, Jiaming Dong, Junwen Duan, Hao Yang, Yue Li, Yaxin Wang, Meilin Li, Ying Liu, Zhitao Shen, Rong Liu, Ruirui Cao, Fumin Li, Minshen Zhu, Yang Huang   +17 more
wiley   +1 more source