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Branched Chain Amino Acids [PDF]
Annual Review of Physiology, 2019 Branched chain amino acids (BCAAs) are building blocks for all life-forms. We review here the fundamentals of BCAA metabolism in mammalian physiology. Decades of studies have elicited a deep understanding of biochemical reactions involved in BCAA catabolism.
Michael Neinast +2 more
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Branched chain amino acids prime metabolic inflammation [PDF]
Molecular MetabolismSterile inflammation is associated with a broad range of metabolic stressors including both dietary excess and prolonged fasting. In a 10-day human fasting study, we previously identified a surge in the circulating inflammatory biomarker, C-reactive ...
Nandini K. Doshi +13 more
doaj +2 more sources
Immunometabolism – The Role of Branched-Chain Amino Acids
Frontiers in Immunology, 2022 Immunometabolism has been the focus of extensive research over the last years, especially in terms of augmenting anti-tumor immune responses. Regulatory T cells (Tregs) are a subset of CD4+ T cells, which have been known for their immunosuppressive roles
Berkay Yahsi, Gurcan Gunaydin
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Immunomodulatory role of branched-chain amino acids [PDF]
Nutrition Reviews, 2018 Branched-chain amino acids (BCAAs) have been associated with immunomodulation since the mid-1970s and 1980s and have been used in the nutritional therapy of critically ill patients. Evidence shows that BCAAs can directly contribute to immune cell function, aiding recovery of an impaired immune system, as well as improving the nutritional status in ...
Andrea Bonvini +2 more
exaly +3 more sources
Research progress on branched-chain amino acid aminotransferases
Frontiers in Genetics, 2023 Branched-chain amino acid aminotransferases, widely present in natural organisms, catalyze bidirectional amino transfer between branched-chain amino acids and branched-chain α-ketoacids in cells.
Can Chen +3 more
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Branched‐chain amino acids [PDF]
Journal of Gastroenterology and Hepatology, 2000 AbstractThe branched‐chain amino acids (BCAA), isoleucine, leucine and valine, are unique in that they are principally metabolized extrahepatically in the skeletal muscle. This observation led to the investigation of these nutrients in a number of clinical scenarios.
C, Platell +3 more
openaire +2 more sources
Scientific Reports, 2021 Nonalcoholic fatty liver disease is likely to be associated with increased circulating branched-chain amino acids. We investigated the relationship between changes in branched-chain amino acids levels in the serum and improvement in liver fat content ...
Xiulin Shi +11 more
doaj +1 more source