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Branched chain amino acids prime metabolic inflammation [PDF]
Molecular MetabolismSterile inflammation is associated with a broad range of metabolic stressors including both dietary excess and prolonged fasting. In a 10-day human fasting study, we previously identified a surge in the circulating inflammatory biomarker, C-reactive ...
Nandini K. Doshi +13 more
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Norvaline is accumulated after a down-shift of oxygen in
Microbial Cell Factories, 2008 Background Norvaline is an unusual non-proteinogenic branched-chain amino acid which has been of interest especially during the early enzymological studies on regulatory mutants of the branched-chain amino acid pathway in Serratia marcescens.
Bernhardt Jörg +5 more
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Primary Roles of Branched Chain Amino Acids (BCAAs) and Their Metabolism in Physiology and Metabolic Disorders [PDF]
MoleculesLeucine, isoleucine, and valine are collectively known as branched chain amino acids (BCAAs) and are often discussed in the same physiological and pathological situations.
Tomoki Bo, Junichi Fujii
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Research progress on branched-chain amino acid aminotransferases
Frontiers in Genetics, 2023 Branched-chain amino acid aminotransferases, widely present in natural organisms, catalyze bidirectional amino transfer between branched-chain amino acids and branched-chain α-ketoacids in cells.
Can Chen +3 more
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Branched Chain Amino Acids [PDF]
Annual Review of Physiology, 2019 Branched chain amino acids (BCAAs) are building blocks for all life-forms. We review here the fundamentals of BCAA metabolism in mammalian physiology. Decades of studies have elicited a deep understanding of biochemical reactions involved in BCAA catabolism.
Michael, Neinast +2 more
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Branched‐chain amino acids [PDF]
Journal of Gastroenterology and Hepatology, 2000 AbstractThe branched‐chain amino acids (BCAA), isoleucine, leucine and valine, are unique in that they are principally metabolized extrahepatically in the skeletal muscle. This observation led to the investigation of these nutrients in a number of clinical scenarios.
C, Platell +3 more
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Scientific Reports, 2021 Nonalcoholic fatty liver disease is likely to be associated with increased circulating branched-chain amino acids. We investigated the relationship between changes in branched-chain amino acids levels in the serum and improvement in liver fat content ...
Xiulin Shi +11 more
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Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism [PDF]
, 2013 Arginase deficiency is a rare autosomal recessive disorder resulting from a loss of the liver arginase isoform, arginase 1 (ARG1), which is the final step in the urea cycle for detoxifying ammonia. ARG1 deficiency leads to hyperargininemia, characterized
Ballantyne, Laurel L. +6 more
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Branched chain amino acids metabolism in heart failure
Frontiers in Nutrition, 2023 As a terminal stage of various cardiovascular diseases, heart failure is of great concern due to its high mortality rate and limited treatment options.
Chenshan Gao, Lei Hou, Lei Hou
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The biological functions and metabolic pathways of valine in swine
Journal of Animal Science and Biotechnology, 2023 Valine is an essential amino acid and a type of branched-chain amino acid. Due to the involvement of branched-chain amino acids in various metabolic pathways, there has been a surge of interests in valine nutrition and its role in animal physiology.
Chuni Wang +6 more
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