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Branched Chain Amino Acids [PDF]

Annual Review of Physiology, 2019
Branched chain amino acids (BCAAs) are building blocks for all life-forms. We review here the fundamentals of BCAA metabolism in mammalian physiology. Decades of studies have elicited a deep understanding of biochemical reactions involved in BCAA catabolism.
Michael, Neinast, Danielle, Murashige, Zoltan, Arany   +2 more
openaire   +4 more sources

Norvaline is accumulated after a down-shift of oxygen in Escherichia coli W3110 [PDF]

Microbial Cell Factories, 2008
Background Norvaline is an unusual non-proteinogenic branched-chain amino acid which has been of interest especially during the early enzymological studies on regulatory mutants of the branched-chain amino acid pathway in Serratia marcescens.
Bernhardt Jörg, Liedert Christina, Falschlehner Christina, Soini Jaakko, Vuoristo Jussi, Neubauer Peter   +5 more
doaj   +2 more sources

Genetic and metabolic drivers of membrane remodeling in Clostridium thermocellum under alcohol stress [PDF]

mSystems
Clostridium thermocellum is a leading candidate for consolidated bioprocessing of lignocellulosic biomass into biofuels due to its native cellulolytic capabilities. Beyond ethanol, C.
Eashant Thusoo, Tyler Jacobson, Bishal D. Sharma, Isabella M. Colón, Lee R. Lynd, Daniel G. Olson, Daniel Amador-Noguez   +6 more
doaj   +2 more sources

Branched chain amino acids prime metabolic inflammation [PDF]

Molecular Metabolism
Sterile inflammation is associated with a broad range of metabolic stressors including both dietary excess and prolonged fasting. In a 10-day human fasting study, we previously identified a surge in the circulating inflammatory biomarker, C-reactive ...
Nandini K. Doshi, Tristan Pesaresi, Trishya Pagadala, William Dion, Yang Zhang, Natalie L. David, Tânia Amorim, Wenjia Wang, G.V. Naveen Kumar, Bokai Zhu, Silvia Liu, Parth Patwari, Pouneh K. Fazeli, Matthew L. Steinhauser   +13 more
doaj   +2 more sources

Dietary amino acid intake and the risk of hypertension: a systematic review and meta-analysis [PDF]

BMC Public Health
Introduction Hypertension (HTN) is a major global health burden. While dietary protein is a known modifiable risk factor, the role of specific amino acids remains controversial.
Neda Izadi, Reihane Hadi, Arman Shafiee, Hanieh Fathi, Mahdieh Niknam, Parisa Amiri   +5 more
doaj   +2 more sources

Research progress on branched-chain amino acid aminotransferases

Frontiers in Genetics, 2023
Branched-chain amino acid aminotransferases, widely present in natural organisms, catalyze bidirectional amino transfer between branched-chain amino acids and branched-chain α-ketoacids in cells.
Can Chen, Hassan Naveed, Hassan Naveed, Keping Chen   +3 more
doaj   +1 more source

Branched‐chain amino acids [PDF]

Journal of Gastroenterology and Hepatology, 2000
AbstractThe branched‐chain amino acids (BCAA), isoleucine, leucine and valine, are unique in that they are principally metabolized extrahepatically in the skeletal muscle. This observation led to the investigation of these nutrients in a number of clinical scenarios.
C, Platell, S E, Kong, R, McCauley, J C, Hall   +3 more
openaire   +2 more sources

Circulating branch chain amino acids and improvement in liver fat content in response to exercise interventions in NAFLD

Scientific Reports, 2021
Nonalcoholic fatty liver disease is likely to be associated with increased circulating branched-chain amino acids. We investigated the relationship between changes in branched-chain amino acids levels in the serum and improvement in liver fat content ...
Xiulin Shi, Hongyan Yin, Jia Li, Caoxin Huang, Yinling Chen, Zheng Chen, Wei Liu, Weijuan Su, Yiping Zhang, Mingzhu Lin, Yan Zhao, Xuejun Li   +11 more
doaj   +1 more source

Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism [PDF]

, 2013
Arginase deficiency is a rare autosomal recessive disorder resulting from a loss of the liver arginase isoform, arginase 1 (ARG1), which is the final step in the urea cycle for detoxifying ammonia. ARG1 deficiency leads to hyperargininemia, characterized
Ballantyne, Laurel L., Funk, Colin D., Kyriakopoulou, Lianna, Mukherjee, Kamalika, Schulze, Andreas, Sin, Yuan Yan, St. Amand, Tim   +6 more
core   +7 more sources

Branched chain amino acids metabolism in heart failure

Frontiers in Nutrition, 2023
As a terminal stage of various cardiovascular diseases, heart failure is of great concern due to its high mortality rate and limited treatment options.
Chenshan Gao, Lei Hou, Lei Hou
doaj   +1 more source