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Branched Chain Amino Acids [PDF]
Annual Review of Physiology, 2019 Branched chain amino acids (BCAAs) are building blocks for all life-forms. We review here the fundamentals of BCAA metabolism in mammalian physiology. Decades of studies have elicited a deep understanding of biochemical reactions involved in BCAA catabolism.
Michael, Neinast +2 more
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Branched‐chain amino acids [PDF]
Journal of Gastroenterology and Hepatology, 2000 AbstractThe branched‐chain amino acids (BCAA), isoleucine, leucine and valine, are unique in that they are principally metabolized extrahepatically in the skeletal muscle. This observation led to the investigation of these nutrients in a number of clinical scenarios.
C, Platell +3 more
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Branched-Chain Amino Acids and Immunity , [PDF]
The Journal of Nutrition, 2006 Although there has been great interest in the effects of amino acids on immune function, little is known about the impact of changes in BCAA availability on the ability of the immune system to function. Human immune cells incorporate BCAA into proteins and are able to oxidize BCAA.
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Branch chain amino acid and melanogenesis [PDF]
Immunopharmacology and Immunotoxicology, 2011 Sir, the recent publication on branch chain amino acid (BCAA) and melanogenesis is very interesting. Cha et al. report that “a complex of BCAAs inhibited melanin production without changes in intercellular tyrosinase activity,” and they propose further that “the complex of BCAAs may be used in the development of safe potential depigmenting agents ...
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Disorders of branched chain amino acid metabolism
Translational Science of Rare Diseases, 2016 The three essential branched-chain amino acids (BCAAs), leucine, isoleucine and valine, share the first enzymatic steps in their metabolic pathways, including a reversible transamination followed by an irreversible oxidative decarboxylation to coenzyme-A derivatives.
Manoli, I., Venditti, C.P.
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Immunometabolism – The Role of Branched-Chain Amino Acids
Frontiers in Immunology, 2022 Immunometabolism has been the focus of extensive research over the last years, especially in terms of augmenting anti-tumor immune responses. Regulatory T cells (Tregs) are a subset of CD4+ T cells, which have been known for their immunosuppressive roles in various conditions including anti-tumor immune responses.
Berkay Yahsi, Gurcan Gunaydin
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Immunomodulatory role of branched-chain amino acids [PDF]
Nutrition Reviews, 2018 Branched-chain amino acids (BCAAs) have been associated with immunomodulation since the mid-1970s and 1980s and have been used in the nutritional therapy of critically ill patients. Evidence shows that BCAAs can directly contribute to immune cell function, aiding recovery of an impaired immune system, as well as improving the nutritional status in ...
Andrea, Bonvini +4 more
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Branched-chain amino acids in liver diseases [PDF]
Translational Gastroenterology and Hepatology, 2013 Branched chain amino acids (BCAAs) are involved in various bioprocess such as protein metabolism, gene expression, insulin resistance and proliferation of hepatocytes. BCAAs have also been reported to suppress the growth of hepatocellular carcinoma (HCC) cells in vitro and to be required for immune cells to perform the function.
Kazuto, Tajiri, Yukihiro, Shimizu
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Branched-Chain Amino Acids and Central Fatigue [PDF]
The Journal of Nutrition, 2006 An account of the tryptophan (Trp)-5-hydroxytryptamine (5-HT)-central fatigue theory is provided and an explanation of how oral administration of BCAAs can decrease fatigue on the basis of this theory is given. The rate-limiting step in the synthesis of 5-HT is the transport of Trp across the blood-brain barrier.
Eric A, Newsholme, Eva, Blomstrand
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, 2015 International Journal of Health, Animal Science and Food Safety, Vol 2, No 1s (2015): Proceeding of Veterinary and Animal Science ...
Ghiringhelli, Matteo +2 more
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