Results 31 to 40 of about 80,674 (255)

The Effect of Branched Chain Amino Acid Supplementation on Stroke-Related Sarcopenia

Frontiers in Neurology, 2022
BackgroundStroke-related sarcopenia is caused by various factors, such as brain damage, systemic catabolic state, skeletal muscle imbalance, and malnutrition.
Min Kyu Park, Sook Joung Lee, Eunseok Choi, Sangjee Lee, JungSoo Lee   +4 more
doaj   +1 more source

Branched-chain amino acid metabolism supports Roseobacteraceae positive interactions in marine biofilms. [PDF]

Appl Environ Microbiol
Interspecies interactions are key factors affecting the stability of microbial communities. However, microbial interactions in marine biofilms, which constitute up to 80% of the microbial biomass in certain marine environments, are not well understood ...
Cui H, Wang S, Fan S, Long H, Lin J, Ding W, Zhang W.   +6 more
europepmc   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Plasma Amino Acid Concentrations Predict Mortality in Patients with End-Stage Liver Disease. [PDF]

PLoS ONE, 2016
The liver plays a key role in amino acid metabolism. In former studies, a ratio between branched-chain and aromatic amino acids (Fischer's ratio) revealed associations with hepatic encephalopathy.
Benedict Kinny-Köster, Michael Bartels, Susen Becker, Markus Scholz, Joachim Thiery, Uta Ceglarek, Thorsten Kaiser   +6 more
doaj   +1 more source

Extraction, Isolation and Nutritional Quality of Coffee Protein

Foods, 2022
Coffee protein is reported to have high levels of branched-chain amino acids of value in sports nutrition and malnutrition recovery. However, data demonstrating this unusual amino acid composition are limited. We investigated the extraction and isolation
Rewati Raman Bhattarai, Hayder Al-Ali, Stuart K. Johnson   +2 more
doaj   +1 more source

Branched-chain amino acid catabolism promotes M2 macrophage polarization. [PDF]

Front Immunol
IntroductionDuring an immune response, macrophages undergo systematic metabolic rewiring tailored to support their functions. Branched-chain amino acid (BCAA) metabolism has been reported to modulate macrophage function; however, its role in macrophage ...
Lu M, Luo D, Zhang Z, Ouyang F, Shi Y, Hu C, Su H, Li Y, Zhang J, Gui Q, Yang TS.   +10 more
europepmc   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Identification, Expression Analysis and Cloning of Capsicum chinense BCAT Gene Family

Guangdong nongye kexue, 2022
【Objective】The purpose of this study is to understand the distribution, properties and expression patterns of members of the BCAT (Branched-chain Aminotransferase) gene family, so as to lay a foundation for further research on the function of Capsicum ...
Bingchun XIE, Junlin HUANG, Songsen WEN, Tao LI, Ying LI, Xiaowan XU, Xiaomei XU, Zhiming1 WU, Zhou HENG   +8 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source