Results 161 to 170 of about 81,174 (260)

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Branched-chain amino acid catabolism initiates volatile synthesis in Gentiana triflora. [PDF]

Planta
Teshima T, Nemoto K, Shimizu M, Yoshida C, Hirabuchi A, Goto F, Nakasato T, Naito Z, Nishihara M.   +8 more
europepmc   +1 more source

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Maternal Protein Restriction and Branched-Chain Amino Acid Supplementation Differentially Affect Maternal Energy Balance and Impair Offspring Growth. [PDF]

Nutrients
Redrovan D, Patra S, Aziz MT, Gorton MW, Chavez EA, Frederiksen S, Rowe J, Pezeshki A, Chelikani PK.   +8 more
europepmc   +1 more source

Gel Electrolytes for Flexible Zinc‐Air Batteries: Design, Challenges, and Perspectives

Advanced Science, EarlyView.
This review summarizes design strategies for gel electrolytes in flexible zinc‐air batteries, focusing on dendrite suppression, interfacial stability, and ultrathin architectures to enhance cycle life and energy density. ABSTRACT Flexible zinc‐air batteries (FZABs) have emerged as promising candidates for next‐generation flexible electronics and large ...
Yapeng Cao, Tengteng Gu, Yuqiong Wen, Xingxing Gao, Jian Wang, Jun Liu   +5 more
wiley   +1 more source

Allosteric Conformational Locking of Sestrin2 by Leucine: An Integrated Computational Analysis of Branched-Chain Amino Acid Recognition and Specificity. [PDF]

Molecules
Zahid MA, Khan A, Sawali MA, Mohamed OA, Gharaibeh AM, Agouni A.   +5 more
europepmc   +1 more source

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

Advanced Science, EarlyView.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen, Zhongyu Wang, Jieping Huang, Fen Li, Ningbo Chen, Yun Ma   +5 more
wiley   +1 more source

Early branched-chain amino acid reduction delays the onset of cognitive decline in a mouse model of Alzheimer's disease. [PDF]

J Alzheimers Dis
Mullins CA, Gannaban RB, Kramer A, Shah H, Haque ZF, Ramezan M, Dehghani F, Palaniyappan AK, Bowers F, MohanKumar SM, MohanKumar PS, Shin AC.   +11 more
europepmc   +1 more source

From Sourcing to End‐of‐Life: Sustainability Challenges and Opportunities in Organic Bioelectronics

Advanced Science, EarlyView.
Organic bioelectronics bridges biology and electronics using organic mixed ionic/electronic conductors. This Perspective addresses sustainability across the full lifecycle of organic bioelectronic materials and devices, offering a framework to guide material sourcing, synthesis, fabrication, application, and end‐of‐life strategies toward bioelectronic ...
Gwennaël Dufil, Marine Batista, Andrea Bionda, Erica Zeglio   +3 more
wiley   +1 more source

Potential subtype-specific alterations in gut microbiota and branched-chain amino acid metabolism in hydrogen- and methane-predominant small intestinal bacterial overgrowth. [PDF]

Sci Rep
Wang Z, Tan W, Zhang P, Xiong H, Zhu L, Cui J, Li L, Guo C, He L, Huang J, Wei H, Liu H.   +11 more
europepmc   +1 more source