Results 61 to 70 of about 179,297 (194)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Amplitude analysis and branching fraction measurement of the decay D s + $$ {D}_s^{+} $$ → π + π 0 π 0

open access: yesJournal of High Energy Physics, 2022
Using a data set corresponding to an integrated luminosity of 6.32 fb −1 recorded by the BESIII detector at center-of-mass energies between 4.178 and 4.226 GeV, an amplitude analysis of the decay D s + $$ {D}_s^{+} $$ → π + π 0 π 0 is performed, and the ...
The BESIII collaboration   +512 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Study of the K0(L) --> pi0 pi0 nu nu-bar decay

open access: yes, 2011
The rare decay K0(L) --> pi0 pi0 nu nu-bar was studied with the E391a detector at the KEK 12-GeV proton synchrotron. Based on 9.4 x 10^9 K0L decays, an upper limit of 8.1 x 10^{-7} was obtained for the branching fraction at 90% confidence level.
Ahn, J. K.   +69 more
core   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Observation of the baryonic B decay B̅^0→Λ_c^+Λ̅ K^- [PDF]

open access: yes, 2011
We report the observation of the baryonic B decay B̅ ^0→Λ_c^+Λ̅ K^- with a significance larger than 7 standard deviations based on 471×10^6 BB̅ pairs collected with the BABAR detector at the PEP-II storage ring at SLAC.
Cheng, C. H.   +8 more
core  

Observation of B+ -> proton Lambdabar gamma

open access: yes, 2004
We report the first observation of the radiative hyperonic B decay B+ -> proton Lambdabar gamma, using a 140 fb-1 data sample recorded on the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric energy e+e- collider.
A. Bondar   +164 more
core   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

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