Results 61 to 70 of about 51,752 (263)

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Masses and branching fractions at CDF [PDF]

open access: yesThe European Physical Journal C, 2003
The authors present a collection of new results on b-meson and {Lambda}{sub b} masses and branching fractions measured at CDF. They have improved the measurement of the {Lambda}{sub b} and B{sub s} mass and they have measured the branching fractions of B{sub s} {yields} D{sub s}{pi}, {Lambda}{sub b} {yields} {Lambda}{sub c}{pi} and B{sub u} {yields ...
openaire   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Measurement of the inclusive branching fraction for

open access: yesPhysics Letters, 2021
Using 5.9 pb$^{−1}$ of e+e− annihilation data collected at center-of-mass energies from 3.640 to 3.701 GeV with the BESIII detector at the BEPCII Collider, we measure the observed cross sections of e+e−→KS0X (where X=anything). From a fit to these observed cross sections with the sum of continuum and ψ(3686) and J/ψ Breit-Wigner functions and ...
Ablikim, M.   +199 more
openaire  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Branching Fractions of the $X(3872)$

open access: yes, 2019
The recoil momentum spectrum from the decay $B^+ \to K^+ +\mathrm{anything}$ has recently been measured by the BaBar collaboration. The spectrum has a peak with invariant mass near the mass of the $X(3872)$ meson. The preliminary measurement by the BaBar collaboration implies that its branching fraction into $J/ψ\, π^+π^-$ is about 4\%.
Braaten, Eric   +2 more
openaire   +2 more sources

Measurement of the absolute branching fraction of the inclusive decay $$\Lambda _c^+ \rightarrow K_S^0X$$ Λ c + → K S 0 X

open access: yesEuropean Physical Journal C: Particles and Fields, 2020
We report the first measurement of the absolute branching fraction of the inclusive decay $$\Lambda _c^+ \rightarrow K_S^0X$$ Λ c + → K S 0 X . The analysis is performed using an $$e^+e^-$$ e + e - collision data sample corresponding to an integrated ...
M. Ablikim   +490 more
doaj   +1 more source

Home - About - Disclaimer - Privacy