Results 111 to 120 of about 489,624 (317)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

STUDY ON THE CRACK BRANCHING BEHAVIOR DURING CRACK PROPAGATION INFLUENCED BY CONSTRAINT

open access: yesJixie qiangdu, 2022
During the crack propagation process, the crack branching behavior makes fracture more unpredictable. In this work, three kinds of crack branching models were selected, and the FEM simulations based on GTN(Gurson-Tvergaard-Needleman) damage model were ...
ZHANG XuDong   +4 more
doaj  

Prediction and experimental evidence of the optimisation of the angular branching process in the thallus growth of Podospora anserina. [PDF]

open access: yesSci Rep, 2022
Ledoux C   +6 more
europepmc   +1 more source

Branching processes in random environment die slowly [PDF]

open access: green, 2008
Vladimir Vatutin, Andreas E. Kyprianou
openalex   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez   +12 more
wiley   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin   +6 more
wiley   +1 more source

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