Results 91 to 100 of about 10,767,248 (303)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Shui kexue jinzhan, 2018 To explore the evolvement characteristics and driving mechanism of a anabranching river channel under the influence of a water control project, this study classifies the branching river channel on the basis of the dynamic split ratio and measured ...
HAN Jianqiao +3 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
A Long Range Dependence Stable Process and an Infinite Variance Branching System [PDF]
We prove a functional limit theorem for the rescaled occupation time fluctuations of a (d, , )- branching particle system (particles moving in Rd according to a symmetric -stable L´evy process, branching law in the domain of attraction of a (1 + )-stable
Luis G. Gorostiza +2 more
core
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
On the Critical Parameters of Branching Random Walks
MathematicsGiven a discrete spatial structure X, we define continuous-time branching processes {ηt}t≥0 that model a population breeding and dying on X. These processes are usually called branching random walks, and ηt(x) denotes the number of individuals alive at ...
Daniela Bertacchi, Fabio Zucca
doaj +1 more source
Functional Limit Theorems for Occupation Time Fluctuations of Branching Systems in the Cases of Large and Critical Dimensions [PDF]
Functional central limit theorem; Occupation time fluctuation; Branching particle system; Generalized Wiener process; Critical ...
Luis G. Gorostiza +2 more
core
3D modelling of branching in plants [PDF]
, 2011 Shoot branching is a key determinant of overall aboveground plant form. During plant development, the number of branches formed strongly influences the amount of light absorbed by the plant, and thus the plant’s competitive strength in terms of light ...
Evers, J.B.
core
emmalouisedavis/TTI-branching-process: Code for: An Imperfect Tool
, 2021 Code used to generate results for manuscript: Davis, E. L., Lucas, T. C., Borlase, A., Pollington, T. M., Abbott, S., Ayabina, D., ... & Klepac, P. (2020).
Emma L Davis
core +1 more source