Results 91 to 100 of about 159,160 (305)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Branching processes in random environment

, 2011
In der folgenden Arbeit werden Eigenschaften von Verzweigungsprozessen in zufälliger Umgebung (engl. branching processes in random environment, kurz BPREs) untersucht. Das Modell geht auf Smith (1969) und Athreya (1971) zurück. Ein BPRE ist ein einfaches
Böinghoff, Christian
core  

Branching bisimilarity with explicit divergence

, 2009
We consider the relational characterisation of branching bisimilarity with explicit divergence. We prove that it is an equivalence and that it coincides with the original definition of branching bisimilarity with explicit divergence in terms of coloured ...
Glabbeek, van, R.J., Glabbeek, Rob Van, Luttik, SP Bas, Luttik, S.P., Trcka, N., Trcka, N Nikola   +5 more
core   +1 more source

Inequalities for Branching Processes

The Annals of Probability, 1973
A branching process is considered for which the conditional distributions of the litter sizes, given the past, are allowed to vary from period to period and are required only to belong to some set $\mathscr{M}$. The process is non-Markovian in general.
openaire   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Functional Limit Theorems for Occupation Time Fluctuations of Branching Systems in the Case of Long-Range Dependence [PDF]

Functional central limit theorem; Occupation time uctuation; Branching particle system; Distribution-valued Gaussian process; Fractional Brownian motion; Sub-fractional Brownian motion; Long-range ...
Luis G. Gorostiza, A. Talarczyk, T. Bojdecki   +2 more
core  

Random walks on Galton-Watson trees with infinite variance offspring distribution conditioned to survive [PDF]

, 2008
We establish a variety of properties of the discrete time simple random walk on a Galton-Watson tree conditioned to survive when the offspring distribution, Z say, is in the domain of attraction of a stable law with index alpha is an element of (1,2]. In
Croydon, David A., Kumagai, Takashi
core  

TAPAs: A Tool for the Analysis of Process Algebras

, 2008
Process algebras are formalisms for modelling concurrent systems that permit mathematical reasoning with respect to a set of desired properties. TAPAs is a tool that can be used to support the use of process algebras to specify and analyze concurrent ...
Calzolai, Francesco, De Nicola, Rocco, F. Calzolai, Loreti, Michele, Tiezzi, Francesco, Rocco De Nicola, Michele Loreti, De Nicola, R, Francesco Tiezzi, R. De Nicola, M. Loreti, Francesco Calzolai   +11 more
core   +1 more source