Results 81 to 90 of about 484,711 (243)

Capturing and Micromechanical Analysis of the Crack-Branching Behavior in Welded Joints

Metals, 2020
During the crack propagation process, the crack-branching behavior makes fracture more unpredictable. However, compared with the crack-branching behavior that occurs in brittle materials or ductile materials under dynamic loading, the branching behavior ...
Wenjie Wang, Jie Yang, Haofeng Chen, Qianyu Yang   +3 more
doaj   +1 more source

The universal behavior of one-dimensional, multi-species branching and annihilating random walks with exclusion

, 2000
A directed percolation process with two symmetric particle species exhibiting exclusion in one dimension is investigated numerically. It is shown that if the species are coupled by branching ($A\to AB$, $B\to BA$) a continuous phase transition will ...
F. van Wijland, G. Mennon, G. Ódor, G. Ódor, G. Ódor, Géza Ódor, H. Hinrichsen, H. Hinrichsen, H. Hinrichsen, H. K. Janssen, I. Jensen, I. Jensen, J. E. de Freitas, J. L. Cardy, J. Marro, M. A. Muñoz, M. A. Muñoz, M. J. Howard, N. Menyhárd N., P. Grassberger, P. Grassberger, S. Kwon, U. C. Täuber, Y. Y. Goldschmidt, Y. Y. Goldschmidt   +24 more
core   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Maximum Likelihood Estimators for a Supercritical Branching Diffusion Process

International Journal of Mathematics and Mathematical Sciences, 2012
The log-likelihood of a nonhomogeneous Branching Diffusion Process under several conditions assuring existence and uniqueness of the diffusion part and nonexplosion of the branching process.
Pablo Olivares, Janko Hernandez
doaj   +1 more source

The Erlang Weighted Tree, A New Branching Process

, 2020
In this paper, we propose a new branching process which we call Erlang Weighted Tree(EWT). EWT appears as the local weak limit of a random graph model proposed by Richard La and Maya Kabkab. We derive the main properties of EWT such as the probability of
Liu, Mingyan, Moharrami, Mehrdad, Subramanian, Vijay, Sundaresan, Rajesh   +3 more
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Using a household structured branching process to analyse contact tracing in the SARS-CoV-2 pandemic [PDF]

Philos Trans R Soc Lond B Biol Sci, 2021
Fyles M, Fearon E, Overton C, University of Manchester COVID-19 Working Group, Wingfield T, Medley GF, Hall I, Pellis L, House T.   +8 more
europepmc   +2 more sources