Results 131 to 140 of about 1,836 (281)

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

Advection, diffusion and linear transport in a single path-sampling Monte-Carlo algorithm: Getting insensitive to geometrical refinement. [PDF]

PLoS One
Ibarrart L, Blanco S, Caliot C, Dauchet J, Eibner S, El Hafi M, Farges O, Forest V, Fournier R, Gautrais J, Konduru R, Penazzi L, Trégan JM, Vourc'h T, Yaacoub D.   +14 more
europepmc   +1 more source

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

Investigation of cell development and tissue structure network based on natural Language processing of scRNA-seq data. [PDF]

J Transl Med
Wei S, Lu Y, Wang P, Li Q, Shuai J, Zhao Q, Lin H, Peng Y.   +7 more
europepmc   +1 more source

Branching structure for an (L-1) random walk in random environment and its applications [PDF]

, 2010
Wenming Hong, Huaming Wang
openalex   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Historical Lattice Trees. [PDF]

Commun Math Phys, 2023
Cabezas M, Fribergh A, Holmes M, Perkins E.   +3 more
europepmc   +1 more source

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Effects of inbreeding on balancing selection: insights from Fisher's geometric model. [PDF]

Genetics
Olito C, Connallon T.
europepmc   +1 more source

Survival and complete convergence for a branching annihilating random walk

Matthias Birkner, Alice Callegaro, Jǐŕı Černý, Nina Gantert, Pascal Oswald   +4 more
openalex   +2 more sources