TREX1, a predator for treating MSI‐H tumors?
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
CARE-DN: An Extension of the CARE Guidelines for Dry Needling Case Reports. [PDF]
Tzigkounakis G +13 more
europepmc +1 more source
Brand extensions into the hospitality industry by luxury fashion labels and national identity: the cases of Hotel Missoni Edinburgh and Maison Moschino [PDF]
Alice Dallabona
openalex
An exploratory qualitative study of brand associations as a means for brand extensions : Part 1
Hans Kasper, Y Strepp, NS Terblanche
openalex +2 more sources
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Semiautomatic mapping of a national drug terminology to standardised OMOP drug concepts using publicly available supplementary information. [PDF]
Katsch F +4 more
europepmc +1 more source
More than Fit: Brand Extension Authenticity (Web Appendix) [PDF]
Susan Spiggle +2 more
openalex
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Policy Without Penalty: A Review of Pediatric Research Equity Act Noncompliance Letters. [PDF]
Green DJ +3 more
europepmc +1 more source

