Results 11 to 20 of about 2,349,990 (309)

CONSIDERAÇÕES ACERCA DO CONCEITO DE VONTADE DE PODER

Griot, 2012
A proposta é repensar o famoso conceito de Nietzsche, vontade de poder. Procurou-se fazer isto de três maneiras: primeiro o conceito é visado a partir da etimologia da palavra.
Luciano Gomes Brazil
doaj   +3 more sources

O cortiço em três versões: adaptações literárias em sala de aula

Revista Educação e Emancipação, 2020
O artigo resulta de uma dissertação de mestrado que investigou, em uma escola pública de Ensino Fundamental e Médio do município de Guarapari (ES), as relações entre livro, leitor e leitura por meio das contribuições teóricas e metodológicas da Nova ...
Ravena Brazil Vinter
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Assessment of Energy Centres in Brazil: A prospective study for the creation of an integrated energy centre in Brazil [PDF]

, 2019
HEADLINES: • The authors advise the British Embassy to create a Brazil-UK Energy Centre, with legitimacy, independence, and financial sustainability, involving leading stakeholders from the energy sector and academia.
Pinto, João Onofre Pereira, Strapasson, Alexandre, Costa, Hirdan Katarina de Medeiros, Ferreira, Denilson   +3 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Diptera, Psychodidae, Phlebotominae Rondani,1840: range extension and new records from lowland Bolivia [PDF]

Check List, 2010
During a field trip to the town of El Carmen in de Department of Santa Cruz we captured 108 specimens of Phlebotominae (Diptera: Psychodidae). Among the specimens examined, we found five species of sand fly comprising four genera. Four species (Lutzomyia
Reginaldo Brazil, Wagner Passos, Beatriz Brazil, Miroslav Temeljkovitch, José Filho   +4 more
doaj   +3 more sources

IMAGENS DO FEMININO NO BANQUETE DE PLATÃO: SÓCRATES E A FLAUTISTA

Kínesis, 2021
O presente trabalho tem como objetivo central a análise e discussão da questão do feminino nos cinco primeiros discursos que compõem um dos mais célebres diálogos platônicos, O Banquete.
Vicente Thiago Freire Brazil
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source