Results 21 to 30 of about 4,256,926 (340)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Diptera, Psychodidae, Phlebotominae Rondani,1840: range extension and new records from lowland Bolivia [PDF]

Check List, 2010
During a field trip to the town of El Carmen in de Department of Santa Cruz we captured 108 specimens of Phlebotominae (Diptera: Psychodidae). Among the specimens examined, we found five species of sand fly comprising four genera. Four species (Lutzomyia
Reginaldo Brazil, Wagner Passos, Beatriz Brazil, Miroslav Temeljkovitch, José Filho   +4 more
doaj   +3 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

What Is the Molecular Signature of Mind–Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices

Frontiers in Immunology, 2017
There is considerable evidence for the effectiveness of mind–body interventions (MBIs) in improving mental and physical health, but the molecular mechanisms of these benefits remain poorly understood.
Ivana Buric, Ivana Buric, Miguel Farias, Jonathan Jong, Christopher Mee, Inti A. Brazil, Inti A. Brazil, Inti A. Brazil, Inti A. Brazil   +8 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Issues and Challenges in Open and Distance e-Learning: Perspectives from the Philippines

International Review of Research in Open and Distributed Learning, 2016
Rapid advances in information and communications technology in the digital age have brought about significant changes in the practice of distance education (DE) worldwide.
Patricia Brazil Arinto
doaj   +1 more source

IMAGENS DO FEMININO NO BANQUETE DE PLATÃO: SÓCRATES E A FLAUTISTA

Kínesis, 2021
O presente trabalho tem como objetivo central a análise e discussão da questão do feminino nos cinco primeiros discursos que compõem um dos mais célebres diálogos platônicos, O Banquete.
Vicente Thiago Freire Brazil
doaj   +1 more source

Quasi-infra-red fixed points and renormalisation group invariant trajectories for non-holomorphic soft supersymmetry breaking [PDF]

, 1999
In the MSSM the quasi-infra-red fixed point for the top-quark Yukawa coupling gives rise to specific predictions for the soft-breaking parameters. We discuss the extent to which these predictions are modified by the introduction of additional ``non ...
B. Lu, B.D. Dent, J. Krozel, J. Mitchell, M. Brazil, M. Brazil, O. Aichholzer, S. Ramnath, S. Rao, T.A. Slocum, W. Shi, W. Tobler   +11 more
core   +6 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Genetic analysis of members of the species Oropouche virus and identification of a novel M segment sequence [PDF]

, 2015
Oropouche virus (OROV) is a public health threat in South America, and in particular Northern Brazil, causing frequent outbreaks of febrile illness.
Azevedo, Raimunda S.S., da Silva, Daisy E.A., Elliott, Richard M., Hughes, Joseph, Nunes, Marcio R.T., Olszanski Acrani, Gustavo, Rodrigues, Sueli G., Tilston-Lunel, Natasha L., Vasconcelos, Pedro F.C.   +8 more
core   +1 more source