Results 21 to 30 of about 3,864,155 (290)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Diptera, Psychodidae, Phlebotominae Rondani,1840: range extension and new records from lowland Bolivia [PDF]

Check List, 2010
During a field trip to the town of El Carmen in de Department of Santa Cruz we captured 108 specimens of Phlebotominae (Diptera: Psychodidae). Among the specimens examined, we found five species of sand fly comprising four genera. Four species (Lutzomyia
Reginaldo Brazil, Wagner Passos, Beatriz Brazil, Miroslav Temeljkovitch, José Filho   +4 more
doaj   +3 more sources

IMAGENS DO FEMININO NO BANQUETE DE PLATÃO: SÓCRATES E A FLAUTISTA

Kínesis, 2021
O presente trabalho tem como objetivo central a análise e discussão da questão do feminino nos cinco primeiros discursos que compõem um dos mais célebres diálogos platônicos, O Banquete.
Vicente Thiago Freire Brazil
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

What Is the Molecular Signature of Mind–Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices

Frontiers in Immunology, 2017
There is considerable evidence for the effectiveness of mind–body interventions (MBIs) in improving mental and physical health, but the molecular mechanisms of these benefits remain poorly understood.
Ivana Buric, Ivana Buric, Miguel Farias, Jonathan Jong, Christopher Mee, Inti A. Brazil, Inti A. Brazil, Inti A. Brazil, Inti A. Brazil   +8 more
doaj   +1 more source

A taxonomic revision of Camptocerus Dejean (Coleoptera: Curculionidae: Scolytinae) [PDF]

, 2010
The Neotropical ambrosia beetle genus Camptocerus Dejean was revised. Monophyly of the genus was tested using 66 morphological characters in a cladistic analysis. Camptocerus was recovered as monophyletic and 31 species were recognized.
Cognato, Anthony I., Smith, Sarah M.
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Issues and Challenges in Open and Distance e-Learning: Perspectives from the Philippines

International Review of Research in Open and Distributed Learning, 2016
Rapid advances in information and communications technology in the digital age have brought about significant changes in the practice of distance education (DE) worldwide.
Patricia Brazil Arinto
doaj   +1 more source

Diagnostic Utility of the ATG9A Ratio in AP‐4–Associated Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adaptor protein complex 4–associated hereditary spastic paraplegia (AP‐4‐HSP), a childhood‐onset neurogenetic disorder and frequent mimic of cerebral palsy, is caused by biallelic variants in the adaptor protein complex 4 (AP‐4) subunit genes (AP4B1 [for SPG47], AP4M1 [for SPG50], AP4E1 [for SPG51], and AP4S1 [for SPG52]).
Habibah A. P. Agianda, Hyo‐Min Kim, Nicole Battaglia, Joshua Rong, Amy Tam, Enrique Gonzalez Saez‐Diez, Cornelius F. Boerkoel, Afshin Saffari, Vicente Quiroz, Luca Schierbaum, Zainab Zaman, Katerina Bernardi, Darius Ebrahimi‐Fakhari   +12 more
wiley   +1 more source