Results 41 to 50 of about 4,978,756 (344)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Pausânias no Banquete de Platão: Encômio ao Eros sofístico [Pausanias in Plato’s Symposium: encomium to Eros sophistic]

Kalagatos, 2017
O presente artigo tem como objetivo refletir sobre os fundamentos teóricos que balizam os argumentos apresentados por Pausânias em seu célebre discurso no Banquete.
Vicente Brazil
doaj  

DO "CONHECE-TE A TI MESMO" AO "TORNA-TE QUEM TU ÉS": NIETZSCHE CONTRA SÓCRATES EM ECCE HOMO

Revista Trágica, 2019
A partir de uma passagem interessante da autobiografia do filósofo, trabalharemos dois imperativos gregos, o “Conhece-te a ti mesmo”, do oráculo de Delfos, e o “Torna-te o que tu és”, do poeta Píndaro.
Luciano Gomes Brazil
doaj   +1 more source

Alzheimer's disease: an epidemiological analysis over the number of hospitalizations and deaths in Brazil

Arquivos de Neuro-Psiquiatria, 2023
Background Alzheimer's disease (AD) is a neurodegenerative condition characterized by impaired cognitive function. It results in high morbidity, including a large number of hospitalizations, and mortality, generating high costs to health systems.
Eduardo Cattapan Piovesan, Bruna Zanatta de Freitas, Francisco Costa Beber Lemanski, Charles André Carazzo   +3 more
doaj   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Court ADR 25 Years After Pound: Have We Found a Better Way? [PDF]

, 2002
Published in cooperation with the American Bar Association Section of Dispute ...
Brazil, Wayne D.
core  

The Zika Virus Epidemic in Brazil: From Discovery to Future Implications

International Journal of Environmental Research and Public Health, 2018
The first confirmed case of Zika virus infection in the Americas was reported in Northeast Brazil in May 2015, although phylogenetic studies indicate virus introduction as early as 2013.
R. Lowe, Christovam Barcellos, P. Brasil, O. Cruz, N. A. Honório, H. Kuper, M. Carvalho   +6 more
semanticscholar   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

The Strategic Communication Planning in an emergency at the Almirante Álvaro Alberto Nuclear Power Plant (CNAAA)

Brazilian Journal of Radiation Sciences, 2023
In a world where information has a high speed of propagation and is present in the most diverse media, it is essential to follow the news in order to keep the population informed about the actions taken, the real risks and the consequences of an alleged ...
Fernando Barcellos Razuck, Raul dos Santos, Paulo Escarani   +2 more
doaj   +1 more source

Reciprocal Coaching to Reduce the Risk of False Failure in Mediation and Support from Social Science for Coaching Ideas [PDF]

, 2014
Published in cooperation with the American Bar Association Section of Dispute ...
Brazil, Wayne D.
core