Results 201 to 210 of about 42,162 (254)

Dissemination of evidence-based homeopathy before Brazilian medical institutions as a strategy to strengthen the homeopathic medical specialty. [PDF]

Clinics (Sao Paulo)
Teixeira MZ.
europepmc   +1 more source

Extrapolation and pharmacokinetic protocol design optimization for ceftriaxone as an exemplar for the development of antibiotics for children

British Journal of Clinical Pharmacology, EarlyView.
Aim Ceftriaxone is a cephalosporin commonly used for the treatment of acute, severe infections; however, there are conflicting data on its disposition properties in children, making it a suitable case study for the evaluation of the appropriateness of extrapolation approaches based on exposure matching principles for paediatric patients and exploring ...
Daniel Valente Neves, Umberto Villani, Salvatore D'Agate, Sean Oosterholt, Ricardo de Carvalho Cavalli, Fabio Carmona, Vera Lucia Lanchote, Oscar Della Pasqua   +7 more
wiley   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Brazilian higher education system at the crossroads: the undergraduate student mental health crisis. [PDF]

Lancet Reg Health Am
Demenech LM, Schmidt B, Kapczinski F, Nery LEM, Machado MMT, de Boni RB, Brignol S, Lemos SM.   +7 more
europepmc   +1 more source

Acute effects of THC and a CBD+THC combination on cardiovascular haemodynamics and respiratory muscle activity during loaded breathing in healthy adults: A randomized placebo‐controlled crossover study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the acute effects of cannabidiol plus tetrahydrocannabinol (CBD+THC) and tetrahydrocannabinol (THC) oils on cardiovascular haemodynamics, respiratory muscle activity and peripheral tissue perfusion in healthy adults. Methods In this randomized, double‐blind, crossover trial, participants received orally administered ...
Edna Karla Ferreira Laurentino, Marina Lyra L. C. Fagundes, Bruno Lobão Soares, Rodrigo Torres‐Castro, Matias Otto‐Yañez, Emerson Arcoverde Nunes, Matheus Freitas Fernandes Pedrosa, Jéssica Danielle Medeiros da Fonsêca, Vanessa R. Resqueti, Guilherme Augusto de Freitas Fregonezi   +9 more
wiley   +1 more source

Translation, cross-cultural adaptation, and validation into Brazilian Portuguese of the Functional Rhinoplasty Outcome Inventory-17 (FROI-17) for use in patients undergoing Functional Rhinoplasty. [PDF]

Braz J Otorhinolaryngol
Malosá Jorge ME, Soares Silva AC, Quedas A, Malheiros D, Mororo G, Baumann I, Lutaifi Dolci EL, Gutierrez Duran CC.   +7 more
europepmc   +1 more source

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source

Effectiveness, safety, and implementation outcomes of a decentralization program to deliver antivenoms in the Western Brazilian Amazonia: The SAVING program. [PDF]

PLoS Negl Trop Dis
Monteiro W, Murta F, Serrão-Pinto T, Machado V, de Farias AS, Dos Santos AC, Cardoso D, Guimarães Figueira EA, da Silva Chagas ÉC, Habibe LS, da Silva Ipuchima L, de Souza NF, da Silva Lima T, Dourado FS, Montebello L, de Lima-Junior FEF, Casewell NR, Lalloo DG, Almeida-Val F, Lacerda M, Vissoci JRN, Gerardo CJ, Wen FH, Sachett J.   +23 more
europepmc   +1 more source

A protocol for the rehabilitation of patients undergoing mechanical ventilation from the ICU to the post-hospital phase: the MOVE-ICUtoHOME, a multicentre randomised controlled trial. [PDF]

BMJ Open Respir Res
Gastaldi AC, Biazon TMPC, Basíle-Filho A, Dos Santos DO, Tambascio J, Perossi J, Silveira JM, da Silva MG, Wilches-Lunae EC, Usmani O, de Oliveira AS.   +10 more
europepmc   +1 more source