Results 51 to 60 of about 151,827 (307)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Simulation Model for Indirect Tensile Test of Asphalt Mixtures via Discrete Elements
Ingeniería e InvestigaciónThis paper describes the planning, development, programming, and validation of a computational model based on the discrete element method, which was implemented to simulate, considering specific mechanical parameters in two dimensions, the indirect ...
Diego Felipe Guerrero Torres +1 more
doaj +1 more source
Examination of mechanical properties of acrilyc composite materials with different AL2O3 reinforcement by brazil test [PDF]
Tehnika, 2019 Composite materials based on UV-curing acrylates and various alumina-based reinforcements represent material that is suitable for the use in dentistry, but also in other areas.
Vuksanović Marija M. +6 more
doaj
Applied Sciences, 2020 The fracture behavior of the disc specimens in the Brazilian test is closely related to the reliability and accuracy of the experimental results. To comprehensively investigate the effect of various loading methods and rock material types on the failure ...
Diyuan Li +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
A test of competition in Brazilian banking [PDF]
, 2002 This paper implements an empirical test of market power for Brazilian banking based on Bresnahan (1982) and Lau (1982). A dynamic version of the test is applied.
Nakane, Márcio Issao +1 more
core +1 more source
Comparative Study on the Test Method for Tensile Elastic Modulus of Rock Materials
Advances in Civil Engineering, 2019 Rock material has different mechanical behaviors under compressive and tensile loading. Correspondingly, there are two types of elastic modulus: compressive elastic modulus Ec and tensile elastic modulus Et, respectively.
Yan Zhang, Dawei Yu
doaj +1 more source
Investigating the effects of loading rate and mixing design on concrete's direct tensile strength using the CTLC test [PDF]
Analytical and Numerical Methods in Mining EngineeringTensile strength of concrete is measured using direct tensile tests on rectangular concrete samples with dimensions: 19 cm in length, 16 cm in width, 6 cm in thickness, and a central hole of 9 cm in diameter.
Manouchehr Sanei +3 more
doaj +1 more source
Seed viability test of orchids native to the Brazilian Savanna
Pesquisa Agropecuária Tropical, 2021 An essential factor for the formation of a native orchid seed bank is the identification of the viability of stored seeds. This study aimed to determine a methodology for optimizing the tetrazolium test, in the identification of the viability of stored ...
Jackeline Schultz Soares +3 more
doaj +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source