Results 31 to 40 of about 10,694 (214)

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Quantifying welfare impact of bovine respiratory disease in dairy calves via expert elicitation

Italian Journal of Animal Science
Effective methods to quantify the impact of diseases on animal welfare (AW) are essential for improving health management. This study aimed to quantify the impact of Bovine Respiratory Disease (BRD) on dairy calf welfare using expert elicitation combined
Francesca Zaghen, Mariska van der Voort, T. Bas Rodenburg, Henk Hogeveen, Ruurd Jorritsma, Wilma Steeneveld   +5 more
doaj   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Reduction in Mortality of Calves with Bovine Respiratory Disease in Detection with Influenza C and D Virus

Animals, 2022
Both influenza C (ICV) and influenza D (IDV) viruses were recently included as bovine respiratory disease (BRD) causes, but their role in BRD has not been evaluated.
Duanghathai Saipinta, Tanittian Panyamongkol, Phongsakorn Chuammitri, Witaya Suriyasathaporn   +3 more
doaj   +1 more source

Assessment of Growth in Cardio‐Facio‐Cutaneous Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cardio‐facio‐cutaneous (CFC) syndrome is a rare, multiple congenital anomaly disorder in which individuals commonly experience faltering growth; however, systematic analysis of growth parameters in this disorder has not been performed. We recruited 69 participants with CFC through CFC International and collected data on assessing height ...
Kari Johnston, Sandesh C. S. Nagamani, Bradley S. Miller, Katherine A. Rauen, Richard D. Boyce, Salma Musaad, Pilar L. Magoulas   +6 more
wiley   +1 more source

Diagnostic utility of Risk of Malignancy Index in differentiation of benign from malignant ovarian masses

Asian Journal of Medical Sciences, 2023
Background: Women with adnexal masses still pose a diagnostic dilemma and require efficient triaging. The Risk of Malignancy Index (RMI) is an algorithm used for differentiation of malignant from benign ovarian masses. Aims and Objectives: The present
Ankita Kumari , Vani Aditya , Shaila Mitra , Harish Chandra Tiwari   +3 more
doaj   +1 more source

Building phenotypic character matrices for phylogenetic inference: exploration of 35 years of practice

Biological Reviews, EarlyView.
ABSTRACT Recent methodological development in phylogenetic inference has focused predominantly on molecular data. However, renewed interest in other data types, particularly morphological data, has followed from the increased recognition of the power of total evidence and tip‐dating approaches, including fossil data, for inference of time‐scaled trees ...
Melanie J. Hopkins, Mark C. Nikolic, James D. Holmes, Daniela S. Monti, Ernesto E. Vargas‐Parra, Russell D.C. Bicknell, Gregory D. Edgecombe, Katherine Jordan‐Burmeister, John R. Paterson, Shravya Srivastava‐Losey   +9 more
wiley   +1 more source

Sinonasal Mucosal Melanoma: An Enigma

Philippine Journal of Otolaryngology Head and Neck Surgery, 2011
Objective: To report two cases of mucosal melanoma of the sinonasal cavity from India and review the literature emphasizing current important clinical and biologic aspects of this tumor.
Hidayat Ullah, Mirza Qaisar Baig
doaj   +1 more source

Beyond hydrogen: Process design of a biogas steam reformer for Fischer–Tropsch synthesis

The Canadian Journal of Chemical Engineering, EarlyView.
The effect of pressure and steam to carbon ratio on carbon conversion. Abstract We present an analysis of a pilot‐scale multi‐tubular biogas steam reforming reactor, part of a sustainable aviation fuel (SAF) development project in Brazil. The novelty of this work is the application of a new, validated power law kinetic model, specifically developed for
Rafael Belo Duarte, Rafael Dei Tós Barreto, João Lourenço Castagnari Willimann Pimenta, Luiz Mario de Matos Jorge   +3 more
wiley   +1 more source

ESPGHAN position paper on screening, diagnosis and investigation of paediatric metabolic dysfunction‐associated steatotic liver disease

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common reason for elevated liver enzymes in children in Europe, affecting more than 5% of all children. Since the last iteration of this position paper, there have been substantial advances in our understanding of the disease.
Jake P. Mann, Sander Lefere, Maarten Buytaert, Anna Alisi, Cigdem Arikan, Jernej Brecelj, Rachel M. Brown, Irene Degrassi, Giulia Fiore, Emer Fitzpatrick, Sven Francque, Christian A. Hudert, Wojciech Janczyk, Lauren Johansen, Bart G. Koot, Anastasia Konidari, Eberhard Lurz, Claudia Mandato, Maria Mercadal‐Hally, Hadar Moran‐Lev, Antonella Mosca, Giusy Ranucci, Maria Rogalidou, Penelope C. Rose, Piotr Socha, Pietro Vajro, Elvira Verduci, Anita C. E. Vreugdenhil, Natalia Zavhorodnia, Aglaia Zellos, Ruth De Bruyne   +30 more
wiley   +1 more source