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Redistributing BRD4 in inflammation
Science-Business eXchange, 2014A new link between inflammation and atherosclerosis centers on the BET bromodomain protein BRD4 and could provide new targets for intervention.
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BRD4: epigenetic origin and target of CTCL
Blood, 2018In this issue of Blood , Kohnken et al demonstrate a novel oncogenic pathway featuring IL-15-miR-29b-BRD4 positive feedback loop and targeting bromodomain-containing protein 4 (BRD4) disables the oncogenic loop, identifying a potentially effective target for therapy for cutaneous T-cell lymphoma (CTCL) patients ...
Xiaohong Zhao, Jianguo Tao
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Binding Kinetics versus Affinities in BRD4 Inhibition
Journal of Chemical Information and Modeling, 2015Bromodomains (BRDs) are protein modules that selectively recognize histones as a "reader" by binding to an acetylated lysine substrate. The human BRD4 has emerged as a promising drug target for a number of disease pathways, and several potent BRD inhibitors have been discovered experimentally recently.
Ming, Kuang +5 more
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