Results 71 to 80 of about 145,789 (295)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Revista de Derecho (Coquimbo), 2012 El objetivo de este artículo es analizar la sentencia de la Corte Suprema de 7 de septiembre de 2010, rol 1089 - 2009, a propósito del incumplimiento de la obligación de cuidado que recae sobre el establecimiento educacional respecto de sus estudiantes ...
Alvaro Vidal Olivares +1 more
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Damages for Breach of Contract, Impossibility of Performance and Legal Enforceability [PDF]
This paper develops a game-theoretic model of a contract between a creditor and a debtor where equilibrium depends on the damage rule chosen for breach-of-contract situations, the use of impossibility-of-performance excuses and the level of legal ...
Germán Coloma
core
Journal of Marine Science and EngineeringThis study examines the hydrodynamic regimes in Shediac Bay, located in New Brunswick, Canada, with a focus on the breach in the Grande-Digue sand spit. The breach, which was developed in the mid-1980s, has raised concerns about its potential impacts on ...
Chinh Lieou +4 more
doaj +1 more source
Does Perceived Organizational Justice Affect Employees’ Affective Commitment via Psychological Contract Breach? Feelings of Violation as a Moderator [PDF]
Maǧallaẗ Al-Buḥūṯ Al-Mālīyyaẗ wa Al-TiğāriyyaẗAffective commitment has been always regarded as a significant matter; which still occupies most of the organizational research; requiring further need for understanding its main drivers, mechanisms, and suitable conditions.Relying on the norm of ...
غادة عادل عبد المنعم عطية
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Analysis of gradual dike bend breach through 3D numerical simulation
Shuili Shuiyun Gongcheng XuebaoTo address challenges in understanding the comprehensive dynamics of dike bend breaches and the hydraulic features during breach evolution, a 3D numerical model is constructed utilizing FLOW-3D software, RNG k-ε turbulence model, and sediment model.
WANG Jiao +4 more
doaj +1 more source