Results 81 to 90 of about 145,789 (295)

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Unbundling Efficient Breach [PDF]

open access: yes, 2014
Current law and economics scholarship analyzes efficient breach cases monolithically. The standard analysis holds that breach is efficient when performance of a contract generates a negative surplus for the parties.
Bigoni, Maria   +3 more
core   +2 more sources

Information and the Scope of Liability for Breach of Contract: The Rule of Hadley V. Baxendale [PDF]

open access: yes
According to the contract law principle established in the famous nineteenth century English case of Hadley v. Baxendale, and followed ever since in the common law world, liability for a breach of contract is limited to losses "arising ...
Lucian Arye Bebchuk, Steven Shavell
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

THE FUTURE OF ECONOMIC GROWTH: CERTAINTY AND UNCERTAINTY ILLUSION? [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2011
Starting from the concrete realities of the contemporary world reflected in the system of crises which affects the worldwide economy, the outlooks of economical growing and development, the poverty which includes a bigger percent of Earth’s population,
Cristian Dan Pîrvu   +2 more
doaj  

A case review of a Morel Lavellee Lesion with Delayed Presentation

open access: yesMarshall Journal of Medicine, 2018
A Morel Lavellee lesion is a relatively rare post traumatic condition which is missed at the time of early presentation. It involves a closed internal degloving injury where the subcutaneous tissue is torn away from the underlying fascia and thus ...
Ammar Qureshi, Pradeep Monoot
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

UNRAVELLING THE BREACH MECHANISM OF TOKORO RIVER TRIBUTARIES DURING HEAVY RAIN IN AUGUST 2016 [PDF]

open access: yes, 2019
In recent years, bank breaching occurred high frequency. In August 2016, the east pan of Hokkaido in Japan was attacked a heavy rainfall and the tributaries of Tokoro River (Shibayarnasawa River and Toua River) had a bank breach caused by the back water ...
シマダ, トモノリ   +5 more
core  

(In)Efficient Breach of Contract

open access: yes, 2017
Chapter 2 considers the debate over efficient breach theory. It suggests that the dispute between the supporters and critics of efficient breach theory rests on a false premise: efficient breaches exist.
Daniel Markovits, Alan Schwartz
core   +1 more source

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