Results 111 to 120 of about 22,571,102 (275)

Correlating Freeze-Up and Break-Up with Weather Conditions

, 1965
The results of studies on the relation between freeze-up, break-up and weather conditions for a small fresh-water lake in the Ottawa area are reported. Techniques using air temperature records for estimating when a solid ice-cover will form on the lake ...
G P Williams
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The effect of day-long mask wearing on non-invasive break-up time. [PDF]

Graefes Arch Clin Exp Ophthalmol, 2022
Bilici S, Toprak A, Buyukuysal C, Ugurbas SH.   +3 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Accumulation of local defects in the zone of forced elasticity before the front of a failure crack in polymers

Тонкие химические технологии, 2012
This article is dedicated to accumulation of local defects in the zone of forced elasticity before the front of a failure crack in polymers. The mechanism of microcavity formation in the crack and the mechanism of the break-up of loose junctions in the ...
A. A. Valishin, T. S. Stepanova
doaj  

Diagnostic Agreement Between Invasive and Non-invasive Assessments for Preoperative Dry Eye Disease Screening in Patients with Cataracts

Ophthalmology and Therapy
Introduction The aim was to assess the incidence of dry eye disease (DED) and determine the cut-off value for non-invasive keratography tear break-up time (NIKBUT) in patients of European descent with cataracts and without significant comorbidities and ...
Maria Muzyka-Wozniak, Izabela Kaminska, Patrycja Piwowarczyk, Dorota H. Szczesna-Iskander   +3 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Break the chains : a manifesto for the Break the Chains conference to be held on August 8-10, 2003, University of Oregon, Eugene, OR.

, 2003
A manifesto for the conference that was a collaborative effort between the Break the Chains Collective (Eugene, OR), the Anarchist Prisoner's Legal Aid Network (AKA APLAN, Portland, Or) and the National Anarchist Black Cross Network, stating that the ...
Break the Chains (Organization)
core   +1 more source