Results 81 to 90 of about 739,269 (304)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Effect of Crystalline Morphology on Electrical Tree Growth Characteristics of High-Density and Low-Density Polyethylene Blend Insulation

IEEE Access, 2020
The electrical tree initiation and propagation behaviors are a key issue for the polyethylene-based cable insulation. This paper focuses on the effect of crystalline morphology on electrical tree growth characteristics of high-density and low-density ...
Zhonglei Li, Shuofan Zhou, Boxue Du, Mingsheng Fan, Jingang Su   +4 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Breakdown Point Theory for Implied Probability Bootstrap [PDF]

This paper studies robustness of bootstrap inference methods under moment conditions. In particular, we compare the uniform weight and implied probability bootstraps by analyzing behaviors of the bootstrap quantiles when outliers take arbitrarily large ...
Lorenzo Camponovo, Taisuke Otsu
core  

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Breakdown and Groups II [PDF]

The notion of breakdown point was introduced by Hampel (1968, 1971) and has since played an important role in the theory and practice of robust statistics.
Gather, Ursula, Davies, P. Laurie
core  

Breakdown of universal mobility curves in sub-100-nm MOSFETs [PDF]

, 2001
We explore the breakdown of universal mobility behavior in sub-100-nm Si MOSFETs, using a novel three-dimensional (3-D) statistical simulation approach.
Roy, S, Asenov, A., Kaya, S., S. Kaya, A. Asenov, Roy, S., S. Roy, Kaya, S, Asenov, A   +8 more
core   +2 more sources

Thermal and Electrical Fault Diagnosis in Oil–Paper Insulation System: A Comparative Study of Natural Esters and Mineral Oil

Applied Sciences
Power transformer insulation systems, composed of liquid and solid insulators, are continuously exposed to thermal and electrical stresses that degrade their performance over time and may lead to premature failure.
Youssouf Brahami, Samson Okikiola Oparanti, Issouf Fofana, Meghnefi Fethi   +3 more
doaj   +1 more source

Assessment of Surface Degradation of Silicone Rubber Caused by Partial Discharge

Energies, 2019
This paper reports experimental and analytical results of partial discharge degradation of silicone rubber sheets in accordance with proposed procedures.
Kazuki Komatsu, Hao Liu, Mitsuki Shimada, Yukio Mizuno   +3 more
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source