Results 41 to 50 of about 241,347 (311)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of Thickness on the Breakdown Characteristics of Organic Insulation Materials under Microsecond Pulse Voltage

Energies
Thickness affects the electrical breakdown strength (EBD) of insulation materials, and the variation of EBD with thickness (d) is an important basis for insulation design.
Xudong Li, Xin Liu, Jiasheng Ru, Zhibin Zeng, Haoran Bian, Yuefang Li, Hua Zhong, Lei Chen   +7 more
doaj   +1 more source

Study on the breakdown characteristics of conductor-plane gap under vegetation fire condition based on the combustion features

The Journal of Engineering, 2019
The frequent forest fires become a serious threat to the performance of transmission lines’ external insulation, therefore, researches on the breakdown characteristics under flame conditions is of great significance for the transmission lines ...
Daochun Huang, Wei Lu, Tao Yao, Peng Li
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Electric characteristics of pseudo-spark during breakdown phase

, 1993
An analysis of the time-dependent resistive voltage and power deposition during the breakdown phase of pseudo-spark is presented. The voltage and current were measured by specially designed low-inductance capacitive voltage divider and current measuring ...
林斌, Chow Q, LIN, B (reprint author), CHINESE ACAD SCI,INST MECH,BEIJING 100080,PEOPLES R CHINA.   +2 more
core   +1 more source

Breakdown of universal mobility curves in sub-100-nm MOSFETs [PDF]

, 2001
We explore the breakdown of universal mobility behavior in sub-100-nm Si MOSFETs, using a novel three-dimensional (3-D) statistical simulation approach.
Roy, S, Asenov, A., Kaya, S., S. Kaya, A. Asenov, Roy, S., S. Roy, Kaya, S, Asenov, A   +8 more
core   +1 more source

Significantly Improved Electrical Breakdown Strength of Natural Ester Liquid Dielectrics by Doping Ultraviolet Absorbing Molecules

IEEE Access, 2019
In this paper, we experimentally demonstrate that molecules with maximum absorption wavelength corresponding to the first excitation energy of base liquid molecules are able to significantly improve the electrical performances of natural ester oils.
Suning Liang, Feipeng Wang, Zhengyong Huang, Weigen Chen, Youyuan Wang, Jian Li   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Bubble deformation in the repetitive pulsed glycerin pulse forming line and its relation with the liquid breakdown

AIP Advances, 2019
Glycerin is a promising liquid dielectric for pulsed power systems because of its high storage energy density and high resistivity. In order to further improve the energy storage density of glycerin, its breakdown characteristics should be investigated ...
Xiao Yang, Jian-Hua Yang, Xin-Bing Cheng, Jiu-Yuan Geng, Bao-Liang Qian   +4 more
doaj   +1 more source