Results 221 to 230 of about 160,061 (270)

Philadelphia-positive chronic myelogenous leukemia with breakpoint 5? of the breakpoint cluster region but within the bcr gene

Blut, 1987
We report on the first Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) characterized by a rearrangement within the 5' part of the bcr gene on chromosome 22, but outside the restricted breakpoint cluster region. In situ hybridization studies revealed a translocation of the c-abl oncogene to the Ph chromosome and Northern blot ...
H. Schmidt, H. D. Waller, Claus R. Bartram, Ulrike Bross-Bach   +3 more
openaire   +3 more sources

Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib.

Journal of Medicinal Chemistry, 2013
Bcr-Abl(T315I) mutation-induced imatinib resistance remains a major challenge for clinical management of chronic myelogenous leukemia (CML). Herein, we report GZD824 (10a) as a novel orally bioavailable inhibitor against a broad spectrum of Bcr-Abl ...
Xiaomei Ren, Xiaofen Pan, Zhang Zhang, Deping Wang, Xiaoyun Lu, Yupeng Li, Donghai Wen, Huoyou Long, Jinfeng Luo, Yubing Feng, Xiaoxi Zhuang, Fengxiang Zhang, Jianqi Liu, Fang Leng, Xingfen Lang, Yang Bai, M. She, Zheng-chao Tu, Jingxuan Pan, Ke Ding   +19 more
semanticscholar   +1 more source

The Breakpoint Cluster Region Gene on Chromosome 22q11 is Associated with Bipolar Disorder

Biological Psychiatry, 2005
Although the pathogenesis of bipolar disorder remains unclear, heritable factors have been shown to be involved. The breakpoint cluster region (BCR) gene is located on chromosome 22q11, one of the most significant susceptibility loci in bipolar disorder linkage studies.
Kunitoshi Kamijima, Hiroshi Kunugi, M Tatsumi, Ryota Hashimoto, Takeya Okada, Tadafumi Kato, Asako Kosuga   +6 more
openaire   +3 more sources

Cloning of a breakpoint cluster region at band 3q27 involved in human non‐Hodgkin's lymphoma

Genes, Chromosomes and Cancer, 1993
AbstractIn a previous cytogenetic analysis, we showed the recurrence of translocations involving band 3q27 and immunoglobulin gene regions in 20 out of 319 patients with non‐Hodgkin's lymphoma (NHL). We report here the molecular cloning of the translocation breakpoint from tumor cells of a patient (LAR) with t(3;14)(q27;q32) and the isolation of DNA ...
Clotilde Deweindt, J. Kerckaert, H. Tilly, S. Quief, V. Nguyen, C. Bastard   +5 more
semanticscholar   +4 more sources

Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant.

Journal of Medicinal Chemistry, 2010
In the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors, the T315I gatekeeper mutant has emerged as resistant to all currently approved agents.
Wei-sheng Huang, C. Metcalf, R. Sundaramoorthi, Yihan Wang, D. Zou, R. Thomas, Xiaotian Zhu, Lisi Cai, David Wen, Shuangying Liu, J. Romero, Jiwei Qi, I. Chen, Geetha Banda, S. Lentini, Sasmita Das, Qihong Xu, J. Keats, Frank Y. Wang, Scott D. Wardwell, Y. Ning, Joseph T Snodgrass, M. Broudy, K. Russian, Tianjun Zhou, L. Commodore, N. Narasimhan, Qurish K. Mohemmad, J. Iuliucci, V. Rivera, D. Dalgarno, T. Sawyer, T. Clackson, W. Shakespeare   +33 more
semanticscholar   +1 more source

[15] Characterization of breakpoint cluster region kinase and SH2-binding activities

1995
BCR is an interesting signaling protein, whose cellular function is currently unknown. Its biochemical properties include serine kinase activity, SH2-binding activity, and a GTPase-activating activity. The SH2-binding activity is particularly interesting because it may link BCR to signaling pathways involving SH2-containing molecules.
Daniel E. H. Afar, Owen N. Witte
openaire   +3 more sources

Aberrant hypermethylation of the major breakpoint cluster region in 17p11.2 in medulloblastomas but not supratentorial PNETs

Genes, Chromosomes and Cancer, 2000
Deletions of 17p have been consistently reported in up to 50% of medulloblastomas (MBs), and the major breakpoint interval has been localized to chromosome segment 17p11.2. Based on several reports linking aberrant DNA methylation and chromosomal disruption, we examined the methylation pattern in this region by employing restriction landmark genomic ...
Frühwald, Michael C., O'Dorisio, M. S., Dai, Z., Rush, L. J., Krahe, R., Smiraglia, D. J., Pietsch, T., Elsea, S. H., Plass, C.   +8 more
openaire   +4 more sources

Philadelphia-negative chronic myelogenous leukemia with breakpoint cluster region rearrangement: molecular analysis, clinical characteristics, and response to therapy.

Journal of Clinical Oncology, 1988
We have detected rearrangement in the breakpoint cluster region (bcr) on chromosome 22 in cells derived from seven chronic myelogenous leukemia (CML) patients who had no cytogenetic evidence of a chromosome abnormality.
M. Shtalrid, M. Talpaz, M. Blick, P. Romero, H. Kantarjian, K. Taylor, J. Trujillo, J. Schachner, J. Gutterman, R. Kurzrock   +9 more
semanticscholar   +1 more source

CML with E8A2 BCR-ABL Fusion: The Fourth Breakpoint Cluster Region?.

Blood, 2004
Abstract In Ph+ leukemia, the breakpoints within BCR cluster in 3 distinct breakpoint cluster regions (bcr). Rearrangements in the minor (m−), major (M−) and micro (m−) breakpoint cluster region (bcr) give rise to e1a2, e13/14a2 and e19a2 BCR-ABL fusion proteins that are associated with Ph+ ALL, CML and chronic neutrophilic leukemia ...
Shadmehr Demehri, Takeshi Sugimoto, Lay-cheng Lim, Michael W. Deininger, Tamio Koizumi, Beate Schultheis, Thoralf Lange, Peter Paschka, Brian J. Druker, Susan Branford, Andreas Hochhaus, Thomas Kegel, Giovanni Martinelli   +12 more
openaire   +2 more sources

An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region.

Blood, 1998
The human myeloid-lymphoid leukemia gene, MLL (also called ALL-1, Htrx, or HRX ), maps to chromosomal band 11q23. MLL is involved in translocations that result in de novo acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), mixed lineage
Pamela L. Strissel, Reiner Strick, Janet D. Rowley, N. Zeleznik-Le   +3 more
semanticscholar   +1 more source