Results 251 to 260 of about 32,784 (274)

Philadelphia-positive chronic myelogenous leukemia with breakpoint 5? of the breakpoint cluster region but within the bcr gene

Blut, 1987
We report on the first Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) characterized by a rearrangement within the 5' part of the bcr gene on chromosome 22, but outside the restricted breakpoint cluster region. In situ hybridization studies revealed a translocation of the c-abl oncogene to the Ph chromosome and Northern blot ...
C R, Bartram, U, Bross-Bach, H, Schmidt, H D, Waller   +3 more
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The genomic breakpoint in a patient with Philadelphia-positive acute leukemia is 5′ of the breakpoint cluster region

Cancer Genetics and Cytogenetics, 1988
We report a case of acute leukemia in which studies at presentation showed both myeloid and lymphoid cell surface markers. At relapse membrane markers studies were consistent with a leukemia of B-lymphoid lineage. However, immunoglobulin (Ig) and T cell receptor (TCR) beta chain genes were both found in a rearranged configuration.
F, Rassool, L, Foroni, A, Rahemtulla, O, Dreazen, L, Wiedemann, A P, Guo, S, Legon, D, Catovsky, L, Luzzatto, J, Goldman   +9 more
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CML with E8A2 BCR-ABL Fusion: The Fourth Breakpoint Cluster Region?.

Blood, 2004
Abstract In Ph+ leukemia, the breakpoints within BCR cluster in 3 distinct breakpoint cluster regions (bcr). Rearrangements in the minor (m−), major (M−) and micro (m−) breakpoint cluster region (bcr) give rise to e1a2, e13/14a2 and e19a2 BCR-ABL fusion proteins that are associated with Ph+ ALL, CML and chronic neutrophilic leukemia ...
Michael W. Deininger, Brian J. Druker, Andreas Hochhaus, Giovanni Martinelli, Thomas Kegel, Beate Schultheis, Lay-Cheng Lim, Takeshi Sugimoto, Tamio Koizumi, Susan Branford, Peter Paschka, Thoralf Lange, Shadmehr Demehri   +12 more
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Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

Cell, 1984
We have identified and molecularly cloned 46 kb of human DNA from chromosome 22 using a probe specific for the Philadelphia (Ph') translocation breakpoint domain of one chronic myelocytic leukemia (CML) patient. The DNAs of 19 CML patients were examined for rearrangements on chromosome 22 with probes isolated from this cloned region.
J, Groffen, J R, Stephenson, N, Heisterkamp, A, de Klein, C R, Bartram, G, Grosveld   +5 more
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Human Follicular Lymphomas: Identification of a Second t(14;18) Breakpoint Cluster Region

1987
Most follicular lymphomas, which comprise nearly two-thirds of the non-Hodgkin’s lymphomas occurring in U.S. adults, have been shown by cytogenetic analyses to contain a t(14;18) translocation [1, 2]. This breakpoint on chromosome 14 has been localized to band 14q32, the site of the immunoglobulin heavy chain genes. It was thus possible to use human Ig
N, Galili, M L, Cleary, J, Sklar
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Breakpoint cluster region rearrangements in chronic myelogenous leukemia with a masked Philadelphia chromosome

Cancer Genetics and Cytogenetics, 1987
Cytogenetic and molecular analyses were performed in a case of chronic myelogenous leukemia. The cytogenetic study revealed that the leukemic cells of this patient contained a three-way translocation involving chromosomes #5, #9, and #22, resulting in a masked Philadelphia chromosome; the karyotype of the leukemic cells was 46,XY,t(5;22;9)(q31;q11;q34).
J H, Ohyashiki, K, Ohyashiki, A J, Kinniburgh, A, Raza, H D, Preisler, A A, Sandberg   +5 more
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The Breakpoint Cluster Region Gene on Chromosome 22q11 is Associated with Bipolar Disorder

Biological Psychiatry, 2005
Although the pathogenesis of bipolar disorder remains unclear, heritable factors have been shown to be involved. The breakpoint cluster region (BCR) gene is located on chromosome 22q11, one of the most significant susceptibility loci in bipolar disorder linkage studies.
Ryota, Hashimoto, Takeya, Okada, Tadafumi, Kato, Asako, Kosuga, Masahiko, Tatsumi, Kunitoshi, Kamijima, Hiroshi, Kunugi   +6 more
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Distribution of breakpoint within the breakpoint cluster region (bcr) in chronic myelogenous leukemia with a complex philadelphia chromosome translocation

American Journal of Hematology, 1989
AbstractWe analyzed, by Southern blot hybridization, the site of breakpoint within the breakpoint cluster region (bcr) in six patients with a complex Philadelphia chromosome (Ph) translocation and in 23 unselected patients with a standard Ph. The breakpoint was found within the 5.8 kb bcr in all 29 patients. When the bcr was subdivided into four parts,
H, Nishigaki, J, Inazawa, S, Misawa, K, Nishida, T, Okuda, S, Horiike, S, Tsuda, M, Taniwaki, T, Abe   +8 more
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[Polymorphisms in the breakpoint cluster region of bcr gene].

Zhongguo shi yan xue ye xue za zhi, 2010
This study was aimed to explore the single nucleotide polymorphism (SNPs) of breakpoint cluster region of bcr gene in Chinese people and the relationship between SNPs and chronic myelogenous leukemia (CML). A 3.12 kb region spanning from exon 13 to exon 15 in the bcr region were screened by DNA pooling and denaturing high performance liquid ...
Hong, Tian, Shu-Yun, Zhou
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Philadelphia-positive chronic myeloid leukemia with a chromosome 22 breakpoint outside the breakpoint cluster region.

Blood, 1987
In chronic myelogenous leukemia (CML) the reciprocal translocation resulting in the Philadelphia chromosome (Ph1) leads to the formation of a chimeric transcriptional unit carrying both c-abl and bcr genetic information whose transcript is a new fused mRNA of 8.5-kilobases (kb) and whose translational product is a 210-kD phosphoprotein with tyrosine ...
L, Selleri, F, Narni, G, Emilia, A, Colò, P, Zucchini, D, Venturelli, A, Donelli, U, Torelli, G, Torelli   +8 more
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