Results 51 to 60 of about 2,885,121 (322)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Herbal medicines based on a black cohosh extract as a safe alternative for the correction of menopausal symptoms [PDF]

Гинекология, 2014
The review deals with the effectiveness and safety of plant hormones in the treatment of menopausal syndrome. Particular attention is given to black cohosh extract as a drug with distinction from other drugs in this group thanks to its action spectrum ...
I V Kuznetsova
doaj  

Understanding breast cancer as a global health concern

British Journal of Radiology, 2021
Breast cancer is now the most commonly diagnosed cancer in the world. The most recent global cancer burden figures estimate that there were 2.26 million incident breast cancer cases in 2020 and the disease is the leading cause of cancer mortality in ...
L. Wilkinson, T. Gathani
semanticscholar   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study.

Journal of the National Cancer Institute, 1999
BACKGROUND The finding of a decrease in contralateral breast cancer incidence following tamoxifen administration for adjuvant therapy led to the concept that the drug might play a role in breast cancer prevention.
B. Fisher, J. Costantino, D. Wickerham, C. Redmond, M. Kavanah, W. Cronin, V. Vogel, A. Robidoux, N. Dimitrov, J. Atkins, M. Daly, S. Wieand, E. Tan-chiu, L. Ford, N. Wolmark   +14 more
semanticscholar   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Primary Fibrosarcoma of Male Breast: A Rare Entity [PDF]

Journal of Clinical and Diagnostic Research, 2014
Primary fibrosarcoma of the breast is a very rare tumor. However, amongst the Primary Breast Sarcoma (PBS), it is the most common subtype. We present a case of 28-year-old male with lump in right breast of 7 year duration.
Shailaja Shukla, Richa Chauhan, P. Lalita Jyotsna, Manoj Andley   +3 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

Science, 1994
A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods.
Y. Miki, J. Swensen, D. Shattuck-Eidens, P. Futreal, K. Harshman, S. Tavtigian, Qingyun Liu, C. Cochran, L. Bennett, W. Ding, R. Bell, J. Rosenthal, C. Hussey, Thanh V Tran, M. Mcclure, C. Frye, T. Hattier, R. Phelps, A. Haugen-Strano, H. Katcher, Kazuko Yakumo, Z. Gholami, Daniel Shaffer, S. Stone, Steven E. Bayer, Christian Wray, R. Bogden, P. Dayananth, J. R. Ward, P. Tonin, S. Narod, Pamela K. Bristow, F. Norris, L. M. Helvering, P. Morrison, P. Rosteck, Mei Lai, J. Barrett, C. Lewis, S. Neuhausen, L. Cannon-Albright, D. Goldgar, R. Wiseman, A. Kamb, M. Skolnick   +44 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source