Results 61 to 70 of about 2,886,011 (312)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Five-Year Disease-Free Follow-Up of a Borderline Breast Phyllodes Tumor in a 15-year-old Patient

European Journal of Breast Health, 2015
Phyllodes tumors are large breast tumors representing only 1% of breast neoplasms and are rarely seen in young women. Histologically, phyllodes tumors are classified as benign, borderline, or malignant based on the characteristics of the stroma. Although
Sertaç Ata Güler, M. Ümit Uğurlu, Bahadır M. Güllüoğlu   +2 more
doaj   +1 more source

Potential action of cardamom (Elettaria cardamomum) against triple-negative breast cancer

BLDE University Journal of Health Sciences, 2023
Triple-negative breast cancer (TNBC) has been known as havoc among females globally. It is a heterogeneous group of cancer encompassing many breast cancers basically distinct by the lack of estrogen receptor, progesterone receptor, and overextension of ...
Akash Samanta, Kiran Dobhal, Alka Singh, Shalu Verma, Vikash Jakhmola   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The effect of female breast surface area on skin stiffness and tactile sensitivity at rest and following exercise in the heat

Experimental Physiology
Female development includes significant morphological changes across the breast. Yet, whether differences in breast surface area (BrSA) modify breast skin stiffness and tactile sensitivity at rest and after exercise in the heat remain unclear.
Hannah Blount, Alessandro Valenza, Jade Ward, Silvia Caggiari, Peter R. Worsley, Davide Filingeri   +5 more
doaj   +1 more source

Ultrasound-guided Pectoral Nerve Block in Combination with Interpleural Block for Surgical Anesthesia during Breast Cancer Surgery: A Prospective Feasibility Study

International Journal of Advanced Medical and Health Research
Background: The aim of this study was to evaluate the feasibility of ultrasound-guided pectoral nerve block combined with interpleural block for surgical anesthesia during the modified radical mastectomy (MRM).
Pankaj Kundra, P. G. Raju, Stalin Vinayagam, Vikram Kate   +3 more
doaj   +1 more source

In Situ Ductal Carcinoma Arising in Benign Phyllodes Tumor in 19-Year Old Patient: A Case Report

European Journal of Breast Health, 2014
Phyllodes tumors are fibroepithelial lesions and malign forms are rare neoplasms with lower than 1% of all primary breast tumors. Malign forms are usually behaves like sarcomas because they occur in the stroma of the breast.
Muhammet Kadri Çolakoğlu, Erdinç Yenidoğan, Gökhan Giray Akgül, Sultan Çiğdem Irkkan, Yılmaz Özdemir, Mehmet Ali Gülçelik, Mithat Çamlıbel   +6 more
doaj   +1 more source

Adjuvant chemotherapy and survival among patients 70 years of age and younger with node-negative breast cancer and the 21-gene recurrence score of 26-30 [PDF]

, 2019
BACKGROUND: The benefits of chemotherapy in node-negative, hormone receptor-positive, and human epidermal growth factor receptor 2 (HER2)-negative breast cancer patients with the 21-gene recurrence score (RS) of 18-30, particularly those with RS 26-30 ...
Cho, Young Up, Colditz, Graham A, Han, Yunan, Kim, Seung Il, Liu, Ying, Park, Byeong-Woo, Park, Seho, Park, Yikyung, Peterson, Lindsay L, Toriola, Adetunji T   +9 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Management of Patients with Idiopathic Granulomatous Mastitis: Presentation of 13 Cases

European Journal of Breast Health, 2014
Objective:Idiopathic granulomatous mastitis is a rare benign chronic disease of the breast. In this study, we aimed to present our treatment experience in cases diagnosed with idiopathic granulomatous mastitis.Materials and Methods:13 treated cases of ...
Hasan Çalış, Rojbin Karakoyun, Arif Aslaner, Umut Rıza Gündüz, Cumhur Arıcı   +4 more
doaj   +1 more source