Results 51 to 60 of about 2,886,011 (312)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Myofibroblastic sarcoma in breast: a case report and literature review

open access: yesFrontiers in Oncology
Myofibroblastic sarcoma is a malignancy in which myofibroblasts are the main component, with a very low incidence. In this study, we report a case of low-grade myofibroblastic sarcoma (LGMS) in the breast.
Zixi Deng   +4 more
doaj   +1 more source

Metaplastic Breast Carcinoma: Analysis of Clinical and Pathologic Characteristics - A Case Series

open access: yesEuropean Journal of Breast Health, 2016
Objective:Metaplastic breast cancer (MBC) is a rare type of breast cancer that is considered to be clinically aggressive. The clinical significance and prognostic risk factors of MBC are limited.
Semra Salimoğlu   +7 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Gestational Gigantomastia

open access: yesEuropean Journal of Breast Health, 2016
Gestational gigantomastia is a rare condition characterized by fast, disproportionate and excessive breast growth, decreased quality of life in pregnancy, and presence of psychologic as well as physical complications. The etiology is not fully understood,
Halil Türkan   +3 more
doaj   +1 more source

Granular cell tumor of the breast – A tricky masquerader: An interesting case report with review of the literature

open access: yesMedical Journal of Dr. D.Y. Patil Vidyapeeth, 2023
Granular cell tumor is very rarely seen in the breast. It is common in 30–50 years of age but can occur at any age. It simulates malignancy on clinical and radiological examination.
Charusheela Rajesh Gore   +4 more
doaj   +1 more source

Mitochondrial DNA Copy Number Is Associated with Breast Cancer Risk [PDF]

open access: yes, 2013
Mitochondrial DNA (mtDNA) copy number in peripheral blood is associated with increased risk of several cancers. However, data from prospective studies on mtDNA copy number and breast cancer risk are lacking.
AX Fan   +41 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Evaluating the Association between Breast Arterial Calcification and Carotid Plaque Formation

open access: yesEuropean Journal of Breast Health, 2015
Objective: We aimed to evaluate the association between breast arterial calcification (BAC) and carotid plaque formation.Materials and Methods: The study group comprised 47 consecutive BAC (+) women, whereas the control group comprised 33 BAC (–) women ...
Mehmet Yağtu
doaj   +1 more source

Breast within a breast: a review of breast hamartomas

open access: yesInternational Journal of Clinical Practice, 1990
SummaryA 22‐year‐old woman who presented with a large lump in the left breast, subsequently found to be a breast hamartoma, is described. A full review is given of this rare and unusual benign breast lesion, which is likely to be recognised increasingly with the advent of mammographic screening.
J A, Paraskevopoulos   +2 more
openaire   +2 more sources

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