Results 121 to 130 of about 2,749,776 (308)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Sitravatinib plus tislelizumab in locally recurrent or metastatic triple-negative breast cancer: a multi-cohort, single-arm, phase II clinical trial (SPARK Trial)

Molecular Cancer
Background While immunotherapy-chemotherapy combinations are approved for programmed death-ligand 1 (PD-L1)-positive advanced triple-negative breast cancer (TNBC), the therapeutic potential of sitravatinib-enhanced immunotherapy remains unexplored ...
Xi-Yu Liu, Xin-Yi Sui, Ying Xu, Fan Yang, Song-Yang Wu, Xiu-Zhi Zhu, Ke Zuo, Shuo-Wen Cao, Xi Jin, Li Chen, Lin-Xiaoxi Ma, Wen-Juan Zhang, Fu-Gui Ye, Fei-Lin Qu, Ding Ma, Yi Xiao, Gen-Hong Di, Guang-Yu Liu, Ke-Da Yu, Jiong Wu, Xin Hu, Yi-Zhou Jiang, Zhong-Hua Wang, Zhi-Ming Shao, Lei Fan   +24 more
doaj   +1 more source

Detection of single amino acid mutation in human breast cancer by disordered plasmonic self-similar chain [PDF]

, 2015
Maria Laura Coluccio, Francesco Gentile, Gobind Das, Annalisa Nicastri, Antonio Perri, Patrizio Candeloro, Gerardo Perozziello, Remo Proietti Zaccaria, Juan Sebastian Totero Gongora, Salma Alrasheed, Andrea Fratalocchi, Tania Limongi, Giovanni Cuda, Enzo Di Fabrizio   +13 more
openalex   +1 more source

Breast, colon, and prostate screening in the adult population of Croatia: does rural origin matter? [PDF]

, 2007
INTRODUCTION: The aim of this study was to investigate the utilization of breast, colon and prostate cancer screening in the adult Croatian population in a period without national cancer screening programs, with a special interest in respondents' rural ...
Kern, Josipa, Kolčić, Ivana, Polašek, Ozren, Strnad, Marija, Vončina, Luka, Vuletić, Silvije   +5 more
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Investigation into the molecular mechanism of the antiapoptotic functions of CTCF in breast cancer cells using a proteomics approach [PDF]

, 2009
A Vostrov, CF Méndez-Catalá, D Farrar, E Klenova, E Pugacheva, EM Klenova, F Docquier, F Docquier, I Cherhukhin   +8 more
core   +2 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

A Decision Technology System To Advance the Diagnosis and Treatment of Breast Cancer [PDF]

, 2000
Geographical variations in cancer rates have been observed for decades. Described spatial patterns and trends have provided clues for generating hypotheses about the etiology of cancer.
Adya, Monica, Forgionne, Guisseppi A., Gangopadhyay, Aryya   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source