Results 81 to 90 of about 1,426,705 (304)

A family history of breast cancer will not predict female early onset breast cancer in a population-based setting [PDF]

, 2008
: BACKGROUND: An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening.
de Bock, Geertruida H.; id_orcid, Seynaeve, C., Krol-Warmerdam Elly MM, Blom Jannet, de Bock, G.H., Cornelisse, C.J., Blom, Jannet, de Bock, GH, Brekelmans, C.T., Asperen, C.J. (Christi) van, Klijn, J.G., Jacobi, Catharina E., Houwelingen, J.C. van, van Asperen Christi J, Krol-Warmerdam, Elly M. M., Devilee, P, Brekelmans, C.T. (Cecile), Brekelmans Cecile TM, Klijn, Jan G. M., de Bock Geertruida H, Krol-Warmerdam, E.M., Krol-Warmerdam, EMM, van Asperen, C.J., Blom, J. (Jannet), Cornelisse Cees J, Jacobi, C.E., Tollenaar Rob AEM, Cornelisse, Cees J., Krol-Warmerdam, E.M.M. (Elly), Tollenaar, R.A., Seynaeve, C.M. (Caroline), Jacobi, CE, Tollenaar, R.A.E.M. (Rob), de Bock, Geertruida H., Blom, J., van Houwelingen, JC, Tollenaar, Rob A. E. M., van Asperen, Christi J., Brekelmans, CTM (Cecile), Bock, G.H. (Geertruida) de, van Asperen, CJ, Klijn Jan GM, van Houwelingen Johannes C, Devilee, Peter, Seynaeve Caroline, Brekelmans, Cecile T. M., Seynaeve, Caroline, Devilee Peter, Klijn, J.G.M. (Jan), Jacobi Catharina E, van Houwelingen, J.C., Klijn, Jan, Jacobi, C.E. (Catharina), Devilee, P. (Peter), Tollenaar, RAEM, Devilee, P., Cornelisse, C.J. (Cees), van Houwelingen, Johannes C., Blom, J, Cornelisse, CJ   +59 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Risk determination and prevention of breast cancer [PDF]

, 2014
Breast cancer is an increasing public health problem. Substantial advances have been made in the treatment of breast cancer, but the introduction of methods to predict women at elevated risk and prevent the disease has been less successful.
Howell, Anthony; id_orcid, Anderson, Annie, Key, Timothy, Montserat Garcia-Closas, A. Howell (7638146), Saxton, John, M. N. Harvie (7671182), J. M. Saxton (7638221), Annie S Anderson, Saxton, John M, Robert B Clarke, Michelle N Harvie, Evans, Gareth, Key, Timothy J., M. Garcia-Closas (7638116), Garcia-Closas, Montserat, Andy J. Gescher (7671179), Key, TJ, Clarke, Robert; id_orcid, Saxton, JM, D. G. Evans (7608134), Gescher, Andy J, Stephen W Duffy, Key, Timothy J, Clarke, Robert, Harvie, Michelle N., Harvie, Michelle, Anthony Howell, Anderson, Annie S.; id_orcid, Harvie, MN, D Gareth Evans, John M Saxton, Gescher, AJ, Clarke, RB, T. J. Key (7638161), Duffy, Stephen W., Anderson, AS, Anderson, Annie S, R. B. Clarke (7638080), Howell, A, Duffy, SW, Andy J Gescher, Clarke, Robert B., Saxton, John M., Duffy, Stephen W, Evans, Gareth; id_orcid, Duffy, Stephen, S. W. Duffy (7638095), Timothy J Key, Garcia-Closas, M, A. S. Anderson (7638050), Howell, Anthony, Gescher, Andy, Evans, DG, Evans, D. Gareth, Gescher, Andy J.   +55 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A comparative study of mitoxantrone hydrochloride injection and technetium-99 m for tracing axillary sentinel nodes in patients with breast cancer

BMC Cancer
Purpose An earlier multicenter phase III study demonstrated the safety and efficacy of mitoxantrone hydrochloride injection for tracing (MHI) for detecting sentinel lymph nodes (SLNs) in breast cancer patients.
Dechuang Jiao, Xiuchun Chen, Xianfu Sun, Zhenduo Lu, Hao Dai, Chengzheng Wang, Chongjian Zhang, Lianfang Li, Jianghua Qiao, Zhenzhen Liu   +9 more
doaj   +1 more source

Breast cancer

Morecambe Bay Medical Journal, 1960
     
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Standardization of multi disciplinary team treatment for breast cancer (2023 edition)

Zhongguo aizheng zazhi, 2023
Breast cancer has become the most common malignant tumor in the world since 2020. With the diagnosis and therapeutic regimens improvement in breast cancer, survival rate of Chinese patients has been significantly enhanced in recent years.
Specialty Construction-Multidisciplinary Expert Committee for Creating Healthy China Energizing, Society of Breast Cancer China Anti-Cancer Association The   +1 more
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source