Results 61 to 70 of about 4,221,746 (249)
Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley +13 morewiley +1 more sourceOutcomes of Hormone receptor-positive/HER2-negative early breast cancer patients by risk of recurrence groups focusing on the intermediate-risk group: Retrospective analysis from GEICAM studies
Breast Cancer ResearchPurpose Endocrine therapy (ET) with or without abemaciclib/ribociclib is the current standard for intermediate- and high-risk hormone receptor (HR)-positive/HER2-negative early breast cancer (EBC) patients. The NATALEE trial showed that adding 3 years of Sonia Servitja, Eva Carrasco, Raquel Andrés, Álvaro Rodríguez-Lescure, Miguel Martín, Manuel Ruiz-Borrego, Ángel Guerrero, Begoña Bermejo, Antonio Antón, Montserrat Muñoz, Mireia Margeli, Isabel Álvarez, Luis Antonio Fernández, Jose Ponce, Josefina Cruz, Purificación Martínez, Sara López-Tarruella, Margarita Amenedo, Andrea Blasco, Óscar Polonio, Miguel Gil-Gil +20 moredoaj +1 more sourceCommon breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 [PDF]
, 2011 The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by ...Donaldson, A., Danièle Muller, Mark H Greene, L Mai, Phuong,, SWE-BRCA, Madeleine MA Tilanus Linthorst, Engel, C., Pankratz, Vernon, Murray, A, Muy-Kheng Tea, Barrowdale, D., Paul DP Pharoah, Wachenfeldt, v.A., Lynch, Henry, Maria A Caligo, Network, OCG, Wachenfeldt, A. (Anna) von, Anne Marie Gerdes, Boutry-Kryza, Nadia, Barkardottir, Rosa B, F Easton, Douglas,, Varon-Mateeva, Raymonda, Investigators, K, Tilanus-Linthorst, Madeleine M. A., Ozcelik, Hilmi, Pascal Pujol, Breast Canc Family Registry, Kast, K, Kets, C.M. (Marleen), Raymonda Varon Mateeva, Wachenfeldt, V., Martine Dumont, Ejlertsen, B. (Bent), Meindl, A., K Godwin, Andrew, Gschwantler-Kaulich, D. (Daphne), Viel, Alessandra, Meijers-Heijboer, Hanne E.J., Heli Nevanlinna, Patricia A. Ganz, de la Hoya, Miguel, Andrew K. Godwin, Couch, F.J. (Fergus), Skytte, Anne-Bine, Paolo Peterlongo, Janavicius, Ramunas,, Bonanni, Bernardo, Ana Osorio, John L Hopper, Viel, A., Y Karlan, Beth,, Arnold, N, Soller, M., Mai, P.L. (Phuong), Caldes, Trinidad,, Hopper, JL, Olopade, Olufunmilayo, Ruehl, Ina, Gross, J. (Jenny), Eason, J., Chung, Wendy K., Kirsten B. Moysich, A. C. Breast Cancer Family Registry Antoniou, Wachenfeldt, VA, Arver, Brita, A Ganz, Patricia, Pujol, P, Brita Arver, Niederacher, D, Hansen, Thomas V.O., Miguel de la Hoya, Radice, Paolo,, Mark Sherman, Rookus, Matti, Sherman, Mark, Berthet, Pascaline, Benitez, Javier,, Verheus, Martijn, François Cornelis, Godino, J, Neuhausen, S.L. (Susan), Douglas F. Easton, Mulligan, A.M., S Pankratz, Vernon, Osorio, A, Hardouin, A, Os, Theo V., Antonis C. Antoniou, Rebbeck, Timothy R, Esther M John, Mazoyer, S, Aittomäki, K., Evans, D.G. (Gareth), Blanco, I, Rosa B. Barkardottir, Benítez, J. (Javier), Lee, A, Papi, Laura, Muller, D, Gómez García, EB, Kirsten B Moysich, Deissler, Helmut,, van Os, Theo, Gordon Glendon, Lebrun, Marine, Michel Longy, Spurdle, Amanda B, Antoniou, Antonis, Frances P. O'Malley, Pujol, Pascal,, Greene, Mark H., Ganz, Patricia A, Cattaneo, E., Iván Muñoz-Repeto, Berthet, P., Daphne Gschwantler-Kaulich, Gross, Jenny, Henry T. Lynch, J Louise Jones, Susan L Neuhausen, Buys, Saundra M, Mortemousque, Isabelle, Coupier, Isabelle,, Pertesi, M, Fricker, J-P, Ignacio Blanco, Hansen, T.V., Donaldson, A, Peissel, Bernard,, Fredericksen, Z, Henriksson, K, Eeles, R., van Der Luijt, Rob, Niederacher, Dieter,, Hopper, J.L., Godwin, AK, Fassy-Colcombet, M. (Marion), Tilanus-Linthorst, Madeleine M.A., Schäfer, D., Eason, J. (Jacqueline), Peock, Susan,, Cornelis, F, Peterlongo, Paolo, Evans, D. Gareth; id_orcid, Glendon, Gordon,, Pharoah, P.D.P., Dieter Schäfer, Varon-Mateeva, R, Olopade, O.I., Kruse, Torben A, Ganz, P.A. (Patricia), Ros Eeles, Chung, W., Terry, Mary, Beattie, M., Leone, Melanie,, Montagna, M., Javier Godino, Robson, Mark,, Durán, M., Kruse, Torben A., Gregory, H, Noralane M. Lindor, Gadzicki, D., Lindor, Noralane M, Pankratz, Vernon S, Davidson, R., Fricker, Jean-Pierre, Soucy, Penny, Susan J. Ramus, Raymonda Varon-Mateeva, Berthet, P. (Pascaline), Jensen, Uffe, Birk, Tilanus-Linthorst, M.M.A. (Madeleine), Simard, J. (Jacques), Miron, Alexander F., Manoukian, S. (Siranoush), Julian Barwell, Kruse, T.A., Godino, J. (Javier), van Os, Theo,, Os, Theo van, Robson, Mark, Sue Healey, Frances P O'Malley, Gerdes, Anne-Marie, GEMO Study Collaborators, Madeleine MA Tilanus-Linthorst, Bonanni, Bernardo,, Singer, Christian, Caux-Moncoutier, V. (Virginie), Engel, Christoph, Tognazzo, Silvia,, Kauff, N. (Noah), Pertesi, Maroulio,, Torben A. Kruse, Adlard, Julian,, Aittomäki, K. (Kristiina), Sakr, R. (Rita), Ramunas Janavicius, Buys, SM, Ottini, Laura,, Schäfer, Dieter, Marie Stenmark-Askmalm, Soller, Maria,, Janavicius, R, Gevensleben, H, Heidrun Gevensleben, Rookus, M, Hansen, Thomas V., Godwin, Andrew K, Christian Sutter, Meindl, A, DAndrea, Emma,, Karlan, B.Y., Muy Kheng Tea, Sevenet, N., Mai, Phuong L, Toland, Amanda E, Dieter Niederacher, Caux-Moncoutier, V, Benítez, J., Wijnen, J., Muller, Danièle, Hamann, U. (Ute), Ottini, Laura, Moysich, Kirsten B., Gross, J, Madeleine M. A. Tilanus Linthorst, Iván Muñoz Repeto, E Side, Lucy, Susan J Ramus, Henry T Lynch, Arver, B. (Brita Wasteson), Muller, D.W. (Danièle), Isaacs, Claudine, Barrowdale, Daniel,, Esther M. John, Peterlongo, P, Southey, Melissa C., Fredericksen, Z., Hansen, Thomas vO., Olopade, Olufunmilayo I, Bhatia, Jasmine, Wijnen, J, Heinritz, W., Mai, PL, Ozcelik, H, Rosa B Barkardottir, Manoukian, S., Antoniou, A.C. (Antonis), Gerdes, Anne-Marie,, Peock, S. (Susan), Thomassen, M. (Mads), Gómez García, Encarna B., Domchek, SM, Daniel Barrowdale, Henriksson, Karin, Kientz, Caroline,, Caux-Moncoutier, Virginie, Gaudet, M., Kets, C Marleen,, Sevenet, Nicolas,, Kauff, N, Adlard, J.W. (Julian), Adlard, J, Lee, A. (Andrew), Mortemousque, Isabelle,, Easton, Douglas F., Melissa C Southey, Ruehl, I. (Ina), Léoné, Mélanie, Skytte, A.-B. (Anne-Bine), Emma McCann, Lebrun, M., Bernard Peissel, Andrulis, I.L. (Irene), Lazaro, C, Caligo, MA, Hanne EJ Meijers-Heijboer, Os, Theo v, Wang, X.S., Caux-Moncoutier, V., Houghton, C., Heikinen, T. (Tuomas), Jacqueline Eason, Deissler, H. (Helmut), Schmutzler, RK, Anne Bine Skytte, Gadzicki, D. (Dorothea), Saundra M. Buys, Donaldson, Alan,, Gerdes, A-M. (Anne-Marie), O'Malley, Frances, F Miron, Alexander,, Maria A. Caligo, Weitzel, JN, Seynaeve, C.M. (Caroline), Sutter, C., Pharoah, Paul D. P., Ozcelik, H. (Hilmi), Anne-Marie Gerdes, Helmut Deissler, Gaudet, Mia,, Finn C Nielsen, F Miron, Alexander, Garcia, E.B.G., Rookus, M., Eccles, Diana,, Coupier, I., Fassy-Colcombet, Marion, Caligo, Maria A, Toland, Amanda E., Penny Soucy, L Nathanson, Katherine, McCann, E., Mulligan, Anna Marie, Mads Thomassen, Spurdle, Amanda, Meindl, Alfons,, C Southey, Melissa,, Domchek, S.M., Deissler, H., Mazoyer, S., Eeles, Ros, McGuffog, L. (Lesley), Tea, Muy-Kheng, Preisler-Adams, Sabine,, Gadzicki, D, Fergus J Couch, Hansen, TV, Frost, D., Terry, MB, Marcel R Nelen, Vernon S Pankratz, Marion Fassy Colcombet, Os, T. van, Neuhausen, Susan, Hopper, John L., Hansen, TVO, B Barkardottir, Rosa,, Hamann, U, Conxi Lazaro, Schoenbuchner, Ines, Imyanitov, E., Antoniou, AC, Rosemarie Davidson, Isaacs, C., Wachenfeldt, von A, Soller, M, Pujol, Pascal, Davidson, R, Donaldson, Alan, Eason, Jacqueline,, Adlard, Julian, Offit, K, Sherman, M.E. (Mark), Donaldson, A. (Alan), Frost, D, Daly, Mary B, Schaefer, Dieter, Cook, J., Wang, XS, Wang, Xianshu, Ottini, L, Caligo, Maria, Peock, Susan, Hansen, Thomas v, Karlan, BY, Moysich, Kirsten B, Rhiem, K, Mazoyer, S. (Sylvie), E. M. John, Yan, M. (Max), Benitez, Javier, Boutry-Kryza, N, Muñoz-Repeto, I., Papi, L., Ontario Canc Genetics Network, Ding, Yuan,, Lee, A., Nielsen, FC, Luijt, R.B. (Rob) van der, Mary B. Daly, John, EM, Preisler-Adams, S. (Sabine), Barkardottir, R.B. (Rosa), Wachenfeldt, von Anna, Mulligan, AM, Sakr, R., Chung, W. (Wendy), Caldes, T. (Trinidad), Kientz, C, Nathanson, K.L. (Katherine), Izatt, Louise, Savarese, A., Pankratz, V.S. (Shane), Os, Theo, Rita K. Schmutzler, Wang, X, Muller, D., Sutter, C, Gadzicki, Dorothea,, Kientz, Caroline, Manoukian, Siranoush,, Ganz, P.A., Lalloo, F., Heikkinen, T., Alan Donaldson, Wang, Xianshu,, C Marleen Kets, Evans, D G, Mortemousque, I. (Isabelle), Houghton, Catherine,, Ontario Cancer Genetics Network, Adlard, J., Loris Bernard, Bhatia, Jasmine,, Os, Theo, Van, Hamann, Ute, Yan, Max, Cornelis, F. (Franco̧is), Fassy-Colcombet, M., E Tomlinson, Gail, Singer, Christian F, Kruse, T.A. (Torben), Norbert Arnold, Kets, C Marleen, Easton, Douglas, Jean Pierre Fricker, Godwin, A.K. (Andrew), McGuffog, L., Blanco, I., Peissel, Bernard, Stenmark-Askmalm, M., Schaefer, Dieter,, Sevenet, N. (Nicolas), Sevenet, N, Miron, A. (Alexander), P OMalley, Frances,, Radice, Paolo, Frost, Debra, Ganz, PA, van der Luijt, RB, Jeffrey N Weitzel, Fricker, J.P., Arnold, Norbert, L Andrulis, Irene,, Rebbeck, T, Kast, Karin, Pharoah, Paul DP, Ramus, S.J., Barkardottir, Rosa, Caldes, T., Daly, Mary B., Gregory, Helen,, Sakr, R, Murray, A., Miron, AF, Ruehl, Ina,, Sinilnikova, OM, Maroulio Pertesi, Jones, J Louise, Meijers-Heijboer, Hanne E, Fricker, Jean-Pierre,, Chun Ding, Yuan, Side, L.E., Boutry-Kryza, Nadia,, Ramus, Susan J, C. Marleen Kets, Noah Kauff, Ozcelik, H., Caroline Seynaeve, Trinidad Caldes, Daphne Gschwantler Kaulich, Soucy, Penny,, Stoppa-Lyonnet, D., Peterlongo, P. (Paolo), Munoz-Repeto, Ivan,, Rookus, M.A. (Matti), A Ganz, Patricia,, Soller, Maria, Side, Lucy E, Dorkins, H, Daly, M.B. (Mary), Henriksson, Karin,, D P Pharoah, Paul,, Glendon, Gordon, A Kruse, Torben,, van Os, T., Wijnen, Juul, McCann, Emma, H Greene, Mark, Karlsson, Per,, Karin Kast, Fredericksen, Z. (Zachary), Huw Dorkins, Caldes, T, Hoya, M. (Miguel) de La, Paul D. P. Pharoah, Alexander F. Miron, Cattaneo, Elisa, Stenmark-Askmalm, M, D P Pharoah, Paul, Gail E. Tomlinson, Susan M Domchek, Stoppa-Lyonnet, D, Tilanus-Linthorst, Madeleine M A, Peterlongo, P., Lázaro, C. (Conxi), Garcia, Encarna B. Gomez, Barwell, Julian, John, Esther, Greene, Mark H, Gevensleben, H. (Heidrun), Stoppa-Lyonnet, D. (Dominique), Bent Ejlertsen, Montagna, M, Beattie, Mary, Ejlertsen, B, Caux-Moncoutier, Virginie,, Viel, A. (Alessandra), Anneliese Fink-Retter, Peterlongo, Paolo,, Nelen, Marcel R, Encarna B Gómez García, Mulligan, Anna, Marie, Jackie Cook, Dumont, M., Neuhausen, Susan L, Terry, Mary, Beth, Karlsson, P., Lee, Andrew Roger, Barbara Wappenschmidt, Family Registry, Breast Cancer, Meindl, Alfons, Terry, Mary,, Neuhausen, S.L., L Neuhausen, Susan, Lazaro, Conxi, Ejlertsen, Bent,, Evgeny Imyanitov, Anna Marie Mulligan, Terry, Mary B., Soucy, P., Eason, J, Martijn Verheus, Tomlinson, Gail E, Arver, Brita,, Gevensleben, Heidrun, Heikkinen, Tuomas, Toland, Amanda, Isabelle Mortemousque, Tilanus-Linthorst, MMA, Dorkins, Huw, Healey, S, McCann, Emma,, Aittomäki, Kristiina, Heinritz, W. (Wolfram), Couch, Fergus, I Olopade, Olufunmilayo, Tognazzo, S., Tomlinson, G.E., EMBRACE, Dorothea Gadzicki, Hardouin, Agnès, Preisler-Adams, S., Toland, A.E., Greene, M.H., Karlan, Beth, Nevanlinna, H., Coupier, Isabelle, Hoya, M. de la, Nathanson, Katherine L, von Wachenfeldt, Anna, Pasini, B, Sutter, Christian,, A Caligo, Maria,, McGuffog, Lesley, Lazaro, C (Conxi), Fink-Retter, A. (Anneliese), Hilmi Ozcelik, Collaborators, GEMOS, Pharoah, Paul D P, Lee, Andrew, Sakr, Rita, Jensen, UB, Simard, Jacques,, Chung, Wendy,, Ruehl, I., Mazoyer, Sylvie, Christian F. Singer, Olga M Sinilnikova, B Barkardottir, Rosa, Hopper, John, Jones, J L, Schmutzler, Rita, Antoniou, A.C., Heikkinen, Tuomas,, Claudine Isaacs, Boutry-Kryza, N., M Buys, Saundra, Singer, CF, Papi, Laura,, Ding, Yuan C., Hardouin, Agnes,, Blanco, Ignacio, Lynch, Henry T., Mulligan, Anna,, Chun Ding, Yuan,, Ottini, L. (Laura), Andrulis, IL, Fricker, J.P. (Jean Pierre), Susan M. Domchek, Breast Cancer Family Registry, Pankratz, VS, Sherman, M, Stenmark Askmalm, Marie, Lynch, H.T., Side, L. (Lucy), Lazaro, Conxi,, Meijers-Heijboer, E.J. (Hanne), Goldgar, D., Nathanson, Katherine, Tea, Muy Kheng, Aittomaki, Kristiina,, McCann, E. (Emma), Karlan, B.Y. (Beth), Siranoush Manoukian, Nevanlinna, H, Ramus, Susan, Nelen, MR, Schoenbuchner, I., Terry, Mary B, Pascaline Berthet, Caligo, M.A. (Maria), Goldgar, D, Mark H. Greene, Ramus, Susan J., Nevanlinna, H. (Heli), Sylvie Mazoyer, Fink-Retter, A., Meijers-Heijboer, Hanne E J, Hanne E. J. Meijers Heijboer, Ramus, Susan J,, Moysich, Kirsten, Zaffaroni, Daniela, Kets, C.M., Pankratz, V.S., Preisler-Adams, Sabine, Seynaeve, C, Katherine L Nathanson, Hansen, Thomas V O, Simard, J., Easton, D.F., Nelen, Marcel, Sabine Preisler-Adams, Per Karlsson, Bernard, L, Godwin, Andrew K., Jensen, Uffe,, Mary Beth Terry, Radice, P, Gevensleben, Heidrun,, Jones, J.L. (J Louise), Weitzel, J.N. (Jeffrey), F Singer, Christian,, Weitzel, J.N., B Daly, Mary,, Chenevix-Trench, G., Daly, Mary, Sinilnikova, O.M., Terry, Mary Beth, Ding, Y.C., Glendon, G, Hansen, T.V.O. (Thomas), Virginie Caux Moncoutier, Lucy E. Side, Marie Stenmark Askmalm, Lazaro, C., Hansen, Thomas V. O., kConFab Investigators, Imyanitov, E, Montagna, Marco,, Christoph Engel, F Easton, Douglas, Skytte, Anne Bine, Moysich, K.B. (Kirsten), Healey, S. (Sue), Seynaeve, C., Fox, S.B. (Stephen), Bernard, Loris, Kauff, N., van der Luijt, Rob B., Beth Terry, Mary,, Couch, Fergus J, Mai, Phuong, Lebrun, M. (Marine), van der Luijt, Rob B,, Garcia, EBG, Barkardottir, Rosa B., Andrulis, Irene L, Alex Murray, Kristiina Aittomäki, Ganz, Patricia, Olga M. Sinilnikova, Wappenschmidt, B, Fiebig, B. (Britta), Zachary Fredericksen, Max Yan, Niederacher, D., H Greene, Mark,, Fricker, JP, Side, Lucy, Mia Gaudet, Fassy-Colcombet, Marion,, A Caligo, Maria, DAndrea, Emma, Greene, MH, Pujol, P. (Pascal), Pharoah, Paul D, Frost, Debra,, Karlan, Beth Y, Saundra M Buys, van der Luijt, R.B., Yan, M, Kauff, Noah,, Soller, M. (Maria), Tilanus-Linthorst, M.M.A., Verheus, M, Beth Terry, Mary, Georgia Chenevix-Trench, Osorio, Ana, Greene, M.H. (Mark), Offit, Kenneth, Houghton, C. (Catherine), T Lynch, Henry,, Nielsen, Finn, de Al Hoya, Miguel, M Lindor, Noralane,, Ozcelik, Hilmi,, Debra Frost, Agnès Hardouin, Barwell, J., Varon-Mateeva, Raymonda,, M Buys, Saundra,, Miron, A.F., Jones, JL, Thomas vO Hansen, Pharoah, Paul D.P., Jensen, Uffe B, Southey, Melissa, Janavicius, Ramunas, Lynch, H. (Henry), Barrowdale, D, O'Malley, F.P., Beattie, M, L Hopper, John,, de la Hoya, M., Spurdle, Amanda B,, Spurdle, Amanda B., Kast, K., Rob B van der Luijt, Tea, Muy-Kheng,, Heinritz, W, Nielsen, Finn C, Evans, D Gareth, Bonanni, B, Spurdle, AB, Greene, Mark, Soucy, P, van Os, T, Lynch, HT, Bernard, Loris,, Melissa C. Southey, Domchek, S.M. (Susan), Diana Eccles, Os, Theo,, Alexander F Miron, Olufunmilayo I. Olopade, Jasmine Bhatia, Moysich, K.B., Tomlinson, Gail E., Evans, DG, John, E.M. (Esther), Davidson, Rosemarie,, B Moysich, Kirsten, Jones, J. Louise, Rebbeck, Tim,, Gómez García, E.B., Hamann, Ute,, Rebbeck, Tim, Peissel, B. (Bernard), Neuhausen, Susan L., Savarese, A, Jeffrey N. Weitzel, K Godwin, Andrew,, Olufunmilayo I Olopade, Isaacs, C. (Claudine), Fink-Retter, Anneliese, Cattaneo, Elisa,, Davidson, R. (Rosemarie), Gomez Garcia, EncarnaB,, Isabelle Coupier, Yan, Max,, Fiebig, B, Engel, Christoph,, Schaefer, D, P OMalley, Frances, Lesley McGuffog, Olopade, Olufunmilayo I., K Schmutzler, Rita, Offit, Kenneth,, Antoniou, Antonis C, Longy, M., Munoz-Repeto, I, Kientz, C., Andrew K Godwin, T Lynch, Henry, Phuong L. Mai, Amanda E. Toland, Eccles, D., Pasini, B., Zaffaroni, D., Britta Fiebig, Thomassen, Mads,, Fox, Stephen,, Fox, S., Katherine L. Nathanson, Mazoyer, Sylvie,, Fiebig, Britta, Lynch, Henry T, Gross, Jenny,, Sherman, M., Gerdes, A.-M., Thomassen, Mads, Meijers-Heijboer, HEJ, Side, Lucy E., Tilanus-Linthorst, Madeleine, Jones, J Louise,, Kruse, TA, Bhatia, J., Preisler-Adams, S, Barbara Pasini, CIMBA, Weitzel, Jeffrey N, Anna Wachenfeldt, von, Rebbeck, T., Thomas V. O. Hansen, Kenneth Offit, Mai, P.L., Yuan Ding, Evans, D. Gareth, A Kruse, Torben, Gomez Garcia, EncarnaB, Noralane M Lindor, Sakr, Rita,, Imyanitov, E.N. (Evgeny), Eccles, D, Schmutzler, R.K. (Rita), Kets, C. Marleen, Rob B. van der Luijt, Fink-Retter, Anneliese,, Kets, C M, Murray, Alex,, M John, Esther,, Nathanson, K.L., Robson, M., Easton, Douglas F, Gómez García, Encarna, Emma D'Andrea, Chung, W, Coupier, I. (Isabelle), Stenmark-Askmalm, M. (M.), Christian F Singer, Niederacher, Dieter, Chenevix-Trench, G, Marine Lebrun, Zaffaroni, Daniela,, Arver, B., Schoenbuchner, I. (Ines), Moysich, KB, Ruehl, I, Marion Fassy-Colcombet, Tognazzo, S. (Silvia), Mulligan, Anna Marie,, Rhiem, K. (Kerstin), Jensen, Uffe B., McGuffog, Lesley,, Eeles, Ros,, Hansen, Thomas vO, Anna Wachenfeldt, von,, C Antoniou, Antonis,, Lund University., van Wijnen, J (Juul), D. Gareth Evans, Dominique Stoppa Lyonnet, Domchek, Susan M., Pankratz, Vernon S., Marcel R. Nelen, Offit, K., Couch, FJ, Domchek, Susan M,, Evans, D.G., Jensen, Uffe, Meijers-Heijboer, Hanne EJ, Dorkins, H. (Huw), Eeles, R, Nevanlinna, Heli, Ina Ruehl, Cook, Jackie, Schäfer, D, Dorkins, Huw,, Leone, M, Healey, S., John L. Hopper, Jacques Simard, Mary Beattie, B Moysich, Kirsten,, Wendy Chung, Savarese, A. (Antonella), Buys, Saundra M., Engel, C, Peissel, B., Meijers-Heijboer, Hanne, Simard, Jacques, C Antoniou, Antonis, Buys, S.M., S Pankratz, Vernon,, Sutter, C. (Christian), Toland, A.E. (Amanda), Verheus, M. (Martijn), Blanco, Ignacio,, Glendon, G., Y Karlan, Beth, Ding, Yuan, Bhatia, J, L Hopper, John, Stenmark-Askmalm, Marie, Louise Izatt, Szabo, Csilla, O'Malley, F.P. (Frances), L Neuhausen, Susan,, Sabine Preisler Adams, Wolfram Heinritz, Glendon, G. (Gord), Hardouin, A. (Agnès), Amanda E Toland, Nevanlinna, Heli,, Tuomas Heikkinen, Izatt, Louise,, Couch, Fergus J., Lindor, N.M., Couch, Fergus J,, Ramus, SJ, Benitez, J, Pertesi, M. (Maroulio), J. Louise Jones, Helen Gregory, Mulligan, Anna M, Houghton, C, Szabo, C, Kientz, C. (Caroline), Tilanus-Linthorst, Madeleine M A,, Couch, F.J., Izatt, L. (Louise), Nadia Boutry-Kryza, Skytte, Anne-Bine,, Jenny Gross, Montagna, Marco, Hamann, U., Duran, M, Tilanus - Linthorst, Madeleine, Ding, Yuan C, Toland, AE, Douglas F Easton, Rookus, Matti,, Pasini, B. (Barbara), Wang, X., Chenevix-Trench, Georgia,, Coupier, I, Szabo, C., Matti Rookus, Theo Os, Irene L Andrulis, Mulligan, Anna, Daly, MB, Eason, Jacqueline, Aittomaki, K, Tognazzo, S, Karlan, Beth Y., Dumont, Martine,, Verheus, M., Léone, M. (Mélanie), Godino, Javier, Laura Ottini, Hansen, Thomas V O,, Weitzel, Jeffrey N., Buys, S.S. (Saundra), Izatt, L. +999 morecore +6 more sourcesTumor-specific MHC-II guides anthracycline exemption and immunotherapy benefit in breast cancer
Biomarker ResearchBackground Anthracycline-based chemotherapy, while foundational in breast cancer treatment, confers substantial cardiotoxicity. Identifying biomarkers to guide anthracycline exemption without compromising efficacy has remained an unresolved clinical ...Zehao Wang, Yanhui Wang, Zhishuang Gao, Yue Zhou, Xiaoting Chen, Rui Xu, Yangsiyuan Zhao, Yi Zhang, Bingqiu Xiu, Jing Liu, Zhiming Shao, Shengmei Gu, Jingyan Xue, Jiong Wu +13 moredoaj +1 more sourceUSP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra +16 morewiley +1 more sourceThe treatment pattern of advanced HR-positive and HER2-negative breast cancer in central southern China: a hospital-based cross-sectional study
BMC CancerAims This investigation aims to elucidate the treatment status of advanced HR+/HER2- breast cancer patients in Hunan Province of Central Southern China from November 2021 to December 2022.Zhe-Yu Hu, Binliang Liu, Ning Xie, Xiaohong Yang, Liping Liu, Huawu Xiao, Jing Li, Hui Wu, Jianxiang Gao, Jun Lu, Xuming Hu, Min Cao, Zhengrong Shui, Can Tian, Quchang Ouyang +14 moredoaj +1 more sourceFinding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer +10 morewiley +1 more source
