Results 41 to 50 of about 1,426,705 (304)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan +6 morewiley +1 more sourceCOMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom +6 morewiley +1 more sourceInfluence of stromal–epithelial interactions on breast cancer in vitro and in vivo
, 2019 Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvironment, as mediators of tumor cell migration, proliferation, and angiogenesis.Dwyer, Róisín M., Hartmann, Marion C., Khan, Sonja, Potter, Shirley M., Boyle, Marie P., Curran, Catherine E., Kerin, Michael J. +6 morecore +1 more sourceEngineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang +12 morewiley +1 more sourceAssessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study. [PDF]
, 2010 INTRODUCTION: Several common breast cancer genetic susceptibility variants have recently been identified. We aimed to determine how these variants combine with a subset of other known risk factors to influence breast cancer risk in white women of ...Olson, J.E., Spurdle, A.B., Severi, G., Anton Culver, Hoda, Hein, R, Hopper, John L., Benitez, J., Knight, Julia A., Matthias W Beckmann, Hall, P, Couch, Fergus J, Wang Gohrke, Shan, Päivi Auvinen, Jianjun Liu, Sigurdson, AJ, Andrulis, Irene L, Anton-Culver, H., Anton-Culver, Hoda, Wang-Gohrke, Shan, Zachary Fredericksen, Apicella, Carmel, Figueroa, Jonine, Louise Brinton, Knight, Julia A, Kosma, V.M., Henrik Flyger, Brinton, L., Beckmann, Matthias W., Heusinger, K, Pharoah, Paul D, Dunning, A.M., Cross, Simon S., Morrison, J, Apicella, C, D Michal Freedman, Linet, Martha S., null null, Dee W West, Freedman, D.M., Yon-Dschun Ko, Morrison, J., Jenny Chang-Claude, Chang Claude, Jenny, Per Hall, Stig E Bojensen, Perez, J.I.A., Julia A Knight, Sara J Schonfeld, Paul D Pharoah, Dite, Gillian S., John, EM, Weerasooriya, Nayana, Giles, Graham G., Georgia Chenevix-Trench, Fletcher, O, West, DW, Lambrechts, D., John L Hopper, Figueroa, J, Kataja, Vesa, Alina Vrieling, Andrulis, Irene L., Vachon, C., Hopper, JL, Beckmann, Matthias W, Thomas Brüning, Fasching, P.A., Fab, Kcon, Ekici, Arif B., Bojensen, SE, Ekici, A.B., Alice S Whittemore, Ziogas, A, Wang-Gohrke, S., Ziogas, Argyrios, Czene, Kamila, Schonfeld, SJ, Cross, SS, Lissowska, J., Mark E Sherman, Johnson, N., Cross, Simon S, Dunning, Alison M, Vrieling, A, Holland, H., Spurdle, Amanda B., Ahmed, S, Spurdle, AB, Janet E Olson, Sherman, Mark E, Flyger, Henrik, Dunning, AM, John, E.M., Czene, K, Kataja, V, Goode, Ellen L, Nordestgaard, Børge G., Easton, DF, Liu, J, Ellen L Goode, Veli-Matti Kosma, Kosma, Veli-Matti, Celine Vachon, Gibson, Lorna J, Esther M John, Liu, Jianjun, Astrid K Irwanto, Ahmed, S., Reumers, Joke, Arias Pérez, José I, Simon S Cross, Brüning, Thomas, Morrison, Jonathan, Mia M Gaudet, Gibson, L.J., Pharoah, P.D., Freedman, D M, John, Esther M., Chenevix-Trench, Georgia, Jolanta Lissowska, Bojensen, Stig E., Lorna J Gibson, Humphreys, MK, Spurdle, Amanda B, Southey, M.C., Schonfeld, Sara J., Johnson, N, Apicella, C., Haeberle, L, Garcia-Closas, M., Vachon, Celine, Joke Reumers, kConFab, Auvinen, P, Olson, JE, Olson, Janet E, Sherman, ME, Ko, Yon-Dschun, John, Esther M, Reed, MWR, M Pilar Zamora, Nordestgaard, B.G., Andrulis, I.L., Ann Smeets, Vachon, C, Fab, KC, Isabel dos Santos Silva, Smeets, A, Fredericksen, Z, Milne, R.L., Laura Baglietto, Gillian S Dite, Hopper, J.L., Jonine Figueroa, Hall, P., Arif B Ekici, Cox, A, Sigurdson, Alice J., García Closas, Montserrat, Ziogas, A., Nichola Johnson, Reed, Malcolm Wr, Judith Heinz, Wang-Gohrke, S, Vrieling, Alina, Gibson, Lorna J., Ekici, AB, Milne, Roger L, Gaudet, Mia M, Flesch-Janys, Dieter, Group, AOCS, Brauch, H, Reed, M.W.R., Malats, Núria, Humphreys, Manjeet K, Network, GENICA, Malats, N., dos Santos Silva, I, Cox, Angela, Brauch, Hiltrud, West, Dee W, Liu, J.J., Anton-Culver, H, Goode, Ellen L., Goode, E.L., Lambrechts, D, José Ignacio Arias Pérez, Lothar Haeberle, Heusinger, Katharina, Olivia Fletcher, Freedman, DM, Arias Pérez, José Ignacio, Ekici, Arif B, Børge G Nordestgaard, Shah, Mitul, Schonfeld, S.J., AOCS, Doug F Easton, Knight, JA, Heinz, J, Nayana Weerasooriya, Brinton, L, Beckmann, M.W., Figueroa, J., Johnson, Nichola, Argyrios Ziogas, Irwanto, Astrid K, Bruning, T., Reed, Malcolm W, Giles, GG, Irwanto, Astrid K., Zamora, M.P., Chenevix-Trench, G, Haeberle, L., Georgia.Trench@qimr.edu.au, GENICA Network, Matthew Kosel, Hopper, John L, Diether Lambrechts, Hall, Per, Nordestgaard, BG, Knight, J.A., Ko, YD, Schonfeld, Sara J, Kosel, M., Baglietto, L, Humphreys, Manjeet K., Roger L Milne, Arto Mannermaa, Katharina Heusinger, Gaudet, Mia M., Sherman, Mark E., Ko, Yon Dschun, Zamora, M Pilar, García-Closas, Montserrat, Fletcher, O., Linet, M.S., Baglietto, Laura, Flyger, H., Pharoah, Paul D., Couch, FJ, Fasching, PA, Southey, MC, Zamora, MP, Brüning, T, Irwanto, AK, Severi, G, Alice J Sigurdson, Rebecca Hein, Reumers, J, Brauch, H., Reed, Malcolm W. R., Dite, Gillian S, Glendon, Gord, Hein, Rebecca, Heinz, J., Jonathan Morrison, Lambrechts, Diether, Bojensen, S.E., Reumers, J., Investigators, KConFab, Sigurdson, Alice J, Smeets, A., Easton, Doug F, Benítez, J, hiltrud.brauch@ikp-stuttgart.de, Flesch-Janys, D., Javier Benítez, Severi, Gianluca, Dite, G.S., Weerasooriya, N., Hoda Anton-Culver, Linet, Martha S, Lissowska, J, Kosma, VM, West, Dee W., Shan Wang-Gohrke, Giles, Graham G, Irwanto, A.K., Auvinen, P., Glendon, G., Flesch-Janys, D, Nordestgaard, Børge G, Southey, Melissa C., Gibson, LJ, Gaudet, MM, Czene, K., Fredericksen, Z., Pharoah, PD, Graham G Giles, Milne, RL, Martha S Linet, Beckmann, MW, Sherman, M.E., Cross, S.S., Kosel, M, Auvinen, Päivi, Shah, M., Linet, MS, Fletcher, Olivia, Shahana Ahmed, Mitul Shah, Milne, Roger L., Humphreys, M.K., Southey, Melissa C, Freedman, D Michal, Smeets, Ann, Heinz, Judith, Arias Pérez, JI, Andrulis, IL, Whittemore, Alice S., Flyger, H, Whittemore, Alice S, Melissa C Southey, Haeberle, Lothar, Easton, Doug F., Bojensen, Stig E, Dieter Flesch-Janys, Couch, Fergus J., Mannermaa, A, Benítez, Javier, Montserrat García-Closas, Fasching, Peter A., Giles, G.G., Holland, Helene, Cox, A., Heusinger, K., Flesch Janys, Dieter, Zamora, M P, Helene Holland, Kosma, Veli Matti, Couch, F.J., Alison M Dunning, Amanda B Spurdle, Angela Cox, West, D.W., Dunning, Alison M., Gord Glendon, Olson, Janet E., Kamila Czene, Mannermaa, A., Kosel, Matthew, Freedman, D. Michal, Hiltrud Brauch, Mannermaa, Arto, Chang-Claude, J., Vesa Kataja, Baglietto, L., Chenevix Trench, Georgia, Easton, D.F., Chang-Claude, Jenny, Malats, N, Lissowska, Jolanta, Whittemore, A.S., Ahmed, Shahana, Malcolm WR Reed, Shah, M, Ko, Y.D., Brinton, Louise, Silva, I.D., Kataja, V., Chenevix-Trench, G., Dite, GS, Irene L Andrulis, Dos Santos Silva, Isabel, Fasching, Peter A, Vrieling, A., Carmel Apicella, Glendon, G, Hein, R., Sigurdson, A.J., Núria Malats, Manjeet K Humphreys, Gaudet, M.M., Fredericksen, Zachary, Weerasooriya, N, Holland, H, Gianluca Severi, Peter A Fasching, Zamora, M. Pilar, Whittemore, AS, Fergus J Couch +381 morecore +1 more sourceKeratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer +13 morewiley +1 more sourceGenome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk [PDF]
, 2013 BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were Side, Lucy E.,, Investigators, k, Pastinen, Tomi, Van Os, Theo A.M., D. F. Easton (7608179), J. Balmana, Ute Hamann (89879), Volorio, Sara, A. Lasa, SWE-BRCA, Tihomirova, L, Imyanitov, E.N., Moeller, ST, L. Senter, Friedlander, M., Muy-Kheng Tea, Barrowdale, D., Öfverholm, Anna, Aittomaki, K., N. Tung, J. Lester, C. F. Singer (7619636), T. Huzarski (7676663), Douglas, F., Shimon Paluch, Shani,, Frans B L Hogervorst, Barkardottir, Rosa B, C. Houdayer (7658699), Pascal Pujol, Dreyfus, Hélène, H. Thorne, Murday, Victoria, Viel, Alessandra, Heli Nevanlinna, Rouleau, E, Shani Shimon Paluch (395262), Yuan Chun Ding (322601), de la Hoya, Miguel, P. Pujol, Capucine Delnatte (395234), Georgia Chenevix-Trench (361), Rita Katharina Schmutzler (395199), Paolo Peterlongo, Kerstin Rhiem (112049), Imyanitov, Evgeny N., Z. Miedzybrodzka, Bonanni, Bernardo, C. Lazaro, Adam Lee, Beattie, Mary S.,, Arnold, N, Caldes, Trinidad,, Dezheng Huo (151859), Sinilnikova, O. M., Pascaline Berthet (395233), J. Garber (7608110), Chung, Wendy K., Arver, Brita, Zachary Fredericksen (146612), Diana M. Eccles (219472), Pujol, P, Sand, S, A. E. Toland (7608026), Niederacher, D, A. Lucassen, Lubinski, Jan, D. E. Cohn (7676702), Tihomirova, L., Miguel de la Hoya, D. Gareth Evans (154186), Ausems, M. G E M, T. Pastinen (7608953), Marco Montagna (238698), Berthet, Pascaline, Taylor, Jane, L. Venat Bouvet, A. Meindl (7619555), Slager, Susan L, B. Bonanni (1681321), Weber, Bernhard HF, Brewer, C., Mulligan, A.M., Sabine Preisler-Adams (395251), Bernhard H. F. Weber (162289), Osorio, A, Hardouin, A, Pastinen, T., Peissel, Bernhard, Kristiina Aittomäki, Esther M John, Mazoyer, S, Friebel, T, Lidereau, Rosette, Blanco, I, Jonson, L, Gaudet, Mia M.,, Patrick J Morrison, Lee, A, Christian F. Singer (308365), Platte, Radke, M. C. Southey (7608080), Lenka Foretova (162255), Platte, Radka, Liljegren, Annelie, Huzarski, Tomasz, Tibiletti, MG, Lebrun, Marine, K. Kohut, Spurdle, Amanda B, Y. Laitman (7608005), Pujol, Pascal,, Ewart Toland, A., M. Tischkowitz, Alexandra V. Stavropoulou (387774), O. Caron, C. Seynaeve, S. V. Blank, Jan Lubinski (59925), C. M. Kets, Berthet, P., L. Snadden, Daphne Gschwantler-Kaulich, A. Romero (3572522), J. Benitez, Wijnen, JT, Singer C.F., Guimbaud, Rosine, Susan L Neuhausen, Frans B. L. Hogervorst (146390), D. Frost, Mortemousque, Isabelle, Coupier, Isabelle,, F. Prieur, et al., Ignacio Blanco, Donaldson, A, M. Lebrun, E. Castro, A. M. Mulligan, Peissel, Bernard,, Fredericksen, Z, Pujana, Miquel Angel, Zakaria Einbeigi, Andrea Gehrig, Stoppa-Lyonnet D., Eeles, RA, Teo, Soo-Hwang,, M. J. Blok, C. Nogues (2482849), E. Niedermayr, Handallou, Sandrine, Wiggins, Jennifer, Kwong, A., Varon-Mateeva, R, Olopade, O.I., C. Engel (7619549), R. Platte (7608131), Kruse, Torben A, Maria Grazia Tibiletti (395246), Cunningham, Julie, Leone, Melanie,, S. Hart, Kristiina Aittomäki (89889), Kuchenbaecker, K. B., Montagna, M., Tomasz Huzarski, Dennis, Joe,, Robson, Mark,, A. Gehrig (7676681), van Asperen, C. J., K. Jaworska, Gadzicki, D., Mette K. Andersen (395271), Lindor, Noralane M, David E Cohn, Vincent, Daniel,, Pankratz, Vernon S, Mia M. Gaudet (146621), Soucy, Penny, E. Fineberg (7658291), Blok, Marinus J.,, Raymonda Varon-Mateeva, S. A. Narod, Rouleau, Etienne,, G. Glendon, Jernström, Helena, Sokolowska, Johanna, Moeller, S, Pujana, M.A., Uhrhammer, Nancy, Haque, Eshika, Buys, SS, Kruse, T.A., Ligtenberg, Marjolijn JL, Vijai, Joseph,, D. Mcbride, T. M. Friebel, M. K. Tea (7619639), Robson, Mark, S. M. Domchek, Sue Healey, A. Murray, Gerdes, Anne-Marie, Jaworska, Katarzyna,, Kara Sarrel, Douglas, Fiona,, Hall, Per, Rookus, M. A., L. Foretova (7676744), S. R. Sand, Lindblom, Annika, Laurie Small, Toulas, Christine, A. M. Dunning (7658231), Adlard, Julian,, Ottini, Laura,, Verhoef, S, Janavicius, R, R. Rosenquist (7652192), Prieur, Fabienne, Nogues, Catherine, S. T. Moeller, Hodgson, Shirley,, Morrison, Patrick J., L. E. Side, D. Huo (7676804), Godwin, Andrew K, C. Toulas, Christian Sutter, J. Adlard (7619510), Meindl, A, Hart, Steven,, Shimon Paluch, S, Mai, Phuong L, F. Bacot (7658246), F. Prieur (7658807), Venat-Bouvet, Laurence,, Szabo, C.I., Kathleen Claes (203063), G. Pfeiler (7658321), Goldgar, David E, Os, T.A. van, Sharon R Sand, Evans, Gareth; id_orcid, Ehrencrona, Hans, Susan J Ramus, A. Donaldson (6262271), Kruse, T, A. Hardouin, Sharon R. Sand (395278), Karin Kast (112042), H. T. Lynch, Barkardottir, R, Z. Fredericksen (7619612), Andersen, MK, Southey, Melissa C., Jaworska, K., Gaudet, MM, Ligtenberg, MJL, Jocelyne Chiquette, M. Porteous, Lars Jønson (395270), Inge Sokilde Pedersen, Tara M. Friebel (395289), A. P. Sokolenko (7676810), Isabelle Coupier (292499), S. Goff, M. J. Blok (7658489), Rosa B Barkardottir, O. Diez (7676606), Ellis, S, Drummond, Sarah, Anna Marie Mulligan (146672), Gerdes, Anne-Marie,, Domchek, SM, Izatt, Luise, Douglas F. Easton (89956), Catherine M. Phelan (219497), Traasdahl Moeller, Sanne, Frans B. L. Hogervorst, L. Varesco (7676669), Melissa C Southey, Os, T. A.,, Christine Lasset, Laurence Venat-Bouvet (395240), Mélanie Léoné (395241), Sinilnikova O.M., S. Goodman, Bubien, Virginie, N. Tung (7608077), Tung, Nadine,, K. Sarrel, Paluch, Shani Shimon, Muranen, TA, Ausems, M.G., Marc Tischkowitz, Szabo, Csilla I, G. Dite, Jacqueline Eason, Hogervorst, F.B., Gomez Garcia, E.B., L. Side, Laurie Small (395257), A. K. Godwin (7608119), Tibiletti, M, I. Blanco, K. Rhiem (7619546), Laitman, Y., Borg, Åke, Kosel, Matthew, Sutter, C., M. G. E. M. Ausems, Anne-Marie Gerdes, S. Preisler Adams, Stefanie Engert (112037), A. V. Stavropoulou (7676780), Chen, Wang, Finn C Nielsen, V. S. Pankratz, Piedmonte, Marion,, V. Bubien, Gibson, Sarah, Coupier, I., N. Ditsch, Hogervorst, Frans B L, M. Leone, K. Durda (7676657), Mads Thomassen, Ellis, Ian, Meindl, Alfons,, Dicks E., Wendy K Chung, M. Soller, Mazoyer, S., Devilee, Peter,, Pastinen, Tomi,, B. Arver (7619687), Gadzicki, D, Jakubowska, Anna,, Searle, Anne, Alexander Miron (28179), J. Cunningham (7676831), C. Jacobs, Fergus J Couch, A. De Pauw, S. B. Chan, Eitan Friedman (196582), Hansen, TV, Rensburg, E. J.,, McLeod, Diane, Neuhausen, Susan L.,, Alison M. Dunning (146796), Terry, MB, M. Piedmonte, Złowocka-Perłowska, Elżbieta, Hansen, TVO, S. L. Slager, Vijai, Joseph, Antoniou, AC, Dorfling, C.M., L. E. Side (7619534), T. Noguchi, Złowocka-Perlowska, Elz bieta, Pujol, Pascal, Olswold, C, S. Giraud, Hansen, T.V.O., Ava Kwong (52115), J. Simard, Feillel, Viviane, Antoniou, A., Nogues, C., Mary S Beattie, Domchek, S, Adlard, Julian, M. B. Daly (7608074), Laitman, Yael,, Frost, D, Silvia Tognazzo (395279), D. Stoppa-Lyonnet (7608194), S. J. Ramus (7608041), Neuhausen, S, Cook, J., M. K. Schmidt, Wang, Xianshu, Ottini, L, Blank, Stephanie V., Karlan, BY, B. Peissel (7619426), J. De Lange, Schmutzler, R. K., Benitez, Javier, Papi, L., F. E. van Leeuwen (7658432), Grazia Tibiletti, Maria,, Ontario Canc Genetics Network, Volorio, S., T. C. T. E. F. Van Cronenburg, Lee, A., Kristoffersson, Ulf, Lenka Foretova, Nielsen, FC, Jonson, L., A. Osorio (7608089), Miquel Angel Pujana (395274), Finn C. Nielsen (206969), Mulligan, AM, Dieter Niederacher (93623), Teo, S.H., Slager, SL, H. Ozcelik (7608029), Angel Pujana, Miquel, EMBRACE (Epidemiological Study of Familial Breast Cancer), Pascal Pujol (8444), Sandra Orsulic, G. Rea, P. Hall (7508258), Izatt, Louise, Huo, D., Southey, M. C., Kaufman, B, Pensotti, Valeria, Jenny Lester (395276), Pfeiler, Georg, Beth Y. Karlan (184236), Sutter, C, Kientz, Caroline, Manoukian, Siranoush,, Longmuir, Mark, T. M. Friebel (7676819), Ganz, P.A., M. J. Kennedy, N. Loman (7676693), Weaver, Joellen, T. Huzarski, E. Olah, S. Hodgson (7633343), Stephanie V Blank, Bernhard H F Weber, Sokolenko, Anna P., Huo, DZ, Houghton, Catherine,, Ontario Cancer Genetics Network, Durda, K., J. T. Wijnen (7658285), C. Rappaport (7676717), Teule, Alex, Hamann, Ute, Pujana, MA, Singer, Christian F, Norbert Arnold, Dennis, Joe, H. Nevanlinna, S. Shimon Paluch (7676723), Rouleau, Etienne, Theo A. M. van Os (395220), Peissel, Bernard, Blanco, I., Buys, S, Stenmark-Askmalm, M., H. Gregory, Miron, A., Orsulic, Sandra,, Ganz, PA, Narod, S.A., Nadine Tung (238710), Ramus, S.J., van Rensburg, Elisabeth J., N. Sevenet, B. H. Weber (7676690), J. Dennis (7658234), Gregory, Helen,, Annemarie H van der Hout, Alexander Miron, Chun Ding, Yuan, C. H. van Deurzen (7676618), Kruse, Torben A.,, Y. C. Ding (7619387), Weaver, J, Flora E. van Leeuwen (248404), Raymonda Varon-Mateeva (196729), van Os, Theo AM, Ramus, Susan J, E. Rouleau (7658759), Noah Kauff, Rosenquist, Richard,, Blok, M.J., E. B. Gomez Garcia, Lasset, C, C. Berlin, Cohn, D.E., Caroline Seynaeve, Arun, Banu K, Trinidad Caldes, Soucy, Penny,, van Leeuwen, Flora E, S. B. Chan (7676807), Hall, P., van Deurzen, C, Walsh, C, Jeffrey N. Weitzel (238722), Francesca Damiola, Soller, Maria, Hansen T.V.O., N. Kauff (7619633), Joe Dennis, Agnès Hardouin, Hansen, Thomas VO, Engert, Stefanie, K. Offit, B. H. F. Weber, L. Izatt (7608137), M. K. Andersen, Vincent, D., Mary Beth Terry (2801), Karin Kast, Friedman E., J. P. Fricker, Huw Dorkins, Olufunmilayo I. Olopade (151873), Aittomäki, K, Hogervorst, FB, Hilmi Ozcelik (20185), Huo, Dezheng, Stenmark-Askmalm, M, S. H. Teo (7675199), Pedersen, IS, M. Belotti, Bent Ejlertsen, Teule, A., Encarna B. Gómez Garcia (5654410), Olah, E., C. M. Phelan, Jacqueline Eason (238727), Montagna, M, I. S. Pedersen (7676726), Ejlertsen, B, E. Friedman (7608035), Anneliese Fink-Retter, L. Foretova, Friedman, Eitan,, Peterlongo, Paolo,, Beattie, MS, Engert, Stefanie,, Spurdle, Amanda B.,, Steven A. Narod (230773), E. N. Imyanitov (7676600), Jackie Cook, al., et, Rosalind A Eeles, K. Henriksson, Rebbeck, Timothy R.,, van Deurzen, Carolien H. M., F. B. Hogervorst (7608212), Wijnen, J.T., Barbara Wappenschmidt, Meindl, Alfons, Eitan Friedman, Blank, Stephanie V, S. Shimon Paluch, Timothy R. Rebbeck (230766), Lazaro, Conxi, Olah, E, Radice P., Zlowocka-Perlowska, E, Jensen, U, Agata, S, Orsulic, S., Ejlertsen, Bent,, F. Douglas (7658597), Kristen Stevens, Eason, J, Soucy, P., B. Bressac De Paillerets, James, Margaret, Paolo Radice (146601), E. Zlowocka Perlowska, Gille, JJP, Hansjoerg Plendl (395250), Złowowcka-Perłowska, Elzbieta, L. Small, Ausems, Magreet G. E. M., Paluch, SS, Friebel, TM, Conxi Lazaro (3405329), Daly, Mary B.,, Vaszko, T, C. Sutter, Agnès Hardouin (395232), Friebel, T.M., Preisler-Adams, S., Glendon, Gord, Greene, M.H., Marinus J. Blok (395217), Nevanlinna, H., Hoya, M. de la, Yves-Jean Bignon (54433), I. L. Andrulis (7608020), von Wachenfeldt, Anna, Lars Jønson, Sutter, Christian,, McGuffog, Lesley, Karlan, B. Y., Fabienne Prieur (246641), Lazaro, C (Conxi), Hilmi Ozcelik, Bacot, Francois,, Collaborators, GEMOS, Bourdon, Violaine, Lee, Andrew, Jensen, UB, Herzog, J, Bacot, Françios, Lucassen, Anneke, Simard, Jacques,, Friedlander, Michael, Theo A M van Os, Xianshu Wang (146610), Olga M Sinilnikova, Steele, L, Waisfisz, Q., Platte, R, Lubinski, Jan,, C. Tirapo, Meijers-Heijboer, H. E., Bacot, F., Blank, SV, A. Calender, Singer, CF, Joan Brunet (75020), M. Kosel (7676585), A. Brady, Hanne E J Meijers-Heijboer, Einbeigi, Z, Blanco, Ignacio, A. P. Sokolenko, Penny Soucy (21792), Andrulis, IL, Steele, L., Weber, B.H., Caroline Seynaeve (95368), Singer, Christian F.,, S. M. Domchek (7608044), Evans, Gareth D., Loud, J.T., Domchek S.M., Anne-Bine Skytte (395263), Hart, Steven, Rappaport, C, Szabo, C. I., M. Emanuelsson, Tea, Muy Kheng, Gille, JJ, J. Paterson, Ausems, Margreet GEM, Ava Kwong, Judith Balmaña (395210), Demange, Liliane, Goldgar, D, Ramus, Susan J., Thomas V O Hansen, Sylvie Mazoyer, S. Manoukian, Dorfling, CM, Loman, N., N. M. Lindor (7619618), Preisler-Adams, Sabine, Pankratz, V.S., Martin, Sue, Hansen, Thomas V O, Goldgar, DE, N. M. Lindor, Sobol, Hagay, Easton, D.F., O. I. Olopade (7607978), Castera, L., Sabine Preisler-Adams, Cunningham, J, O. I. Olopade, Jonson, Lars,, S. Agata, C. Houghton, J. T. Loud, Chenevix-Trench, G., Curtis Olswold (73571), Kulkarni, Anjana, Ausems, MGEM, Sinilnikova, O.M., J. Chiquette, Glendon, G, Ding, Y.C., S. Tognazzo (7619591), Imyanitov, EN, Wang X., Anneliese Fink-Retter (395258), M. H. Greene (7608092), Muranen, T.A., J. Herzog (7676765), Ellis, Steve,, S. Handallou, kConFab Investigators, C. Lasset, M. Stenmark Askmalm, Fournier, Joëlle, Montagna, Marco,, Christoph Engel, Edith Olah (395204), Bignon, Y, Kets, C. M., D. Yannoukakos, J. Maskiell, C. Brewer (7658534), Kenneth Offit (63812), van Rensburg, E, Kauff, N., D. Frost (7608128), Ausems, M.G.E.M., Lehmann, Anna, X. Wang (770484), A. Ewart Toland, Garcia, EBG, Andrulis, Irene L, V. L. Bae-Jump (7676714), Zachary Fredericksen, Elena Fineberg, Side, Lucy, Prieur, Fabienne,, Carole Brewer, Senno Verhoef (395219), T. A. Kruse (6179165), de Pauw, Antoine, HEBON (Hereditary Breast and Ovarian Cancer Research Group Netherlands), Dunning, A.M., Karlan, Beth Y, Piedmonte, M, A. Osorio, E. Kivuva, Orsulic, Sandra, van Rensburg, EJ, Moeller, S.T., J. M. Collee, van Leeuwen, F.E., Stormorken, Astrid, Marc Tischkowitz (395208), A. V. Stavropoulou, Josef Herzog (395277), Osorio, Ana, Soo-Hwang Teo (266270), Offit, Kenneth, Dicks, Ed,, Hogervorst, F. B L, Ozcelik, Hilmi,, Vaszko, Tibor, Murray, Alexandra, Debra Frost, Stevens, Kristen,, Orland Diez (395209), Phuong L. Mai (238716), Ramus, Susan J.,, Mercedes Duran, van Rensburg, E.J., Sobol, Hagay,, D. Vincent (2350123), Janavicius, Ramunas, Barrowdale, D, Brady, Angela, Beattie, M, Jaworska, K, Steve Ellis, P. A. Ganz (7619606), Kast, K., A. B. Skytte, Spurdle, AB, Soucy, P, Chung, W.K., Sarrel, Kara,, D. E. Cohn, Gaudet, M. M., Beattie, M. S., Elena Fineberg (395222), Senter, L, P. Peterlongo, F. Soubrier, Hagay Sobol, Evans, DG, Healey S., Ardern-Jones, Audrey, Sara Volorio (255289), Nadine Tung, Prieur, F, Joe Dennis (395193), S. Smalley, Nathanson, Katherine L.,, Hamann, Ute,, Rookus, Matti A.,, Valeria Pensotti (395247), S. Mazoyer, Weber, BHF, A. Melville, Josef Herzog, Nina Ditsch, Terry, M. B., K. Kast (7619507), Phelan, Catherine M.,, Neuhausen, Susan L., de Lange, J., Christian Sutter (196732), Miron, A, Mercedes Duran (5651374), Bignon, Yves-Jean,, Olufunmilayo I Olopade, Greene, Mark H.,, Agata, S., Isabelle Coupier, Gille, Johannes J.P., J. T. Wijnen, Mulligan, A, Engel, Christoph,, Hodgson, Shirley, Melin, Beatrice, Shirley Hodgson, Alex Murray (395230), L. Tihomirova (7676816), Fineberg, E., Antoniou, Antonis C, Andrew Lee (74302), C. Delnatte, A. Liljegren, Dorfling, Cecilia M.,, M. Piedmonte (7607933), Rogers, M.T., Paterson, Joan, Hogervorst, FBL, M. Duran, L. Winchester, Dennis, J, K. Hill, Thomassen, Mads,, K. Kast, N. Rahman, van Leeuwen, F. E., Capucine Delnatte, Nielsen, F, BCFR, Mazoyer, Sylvie,, M. Gauthier Villars, Trinidad Caldes (3147195), Gaudet, Mia M, Evgeny N Imyanitov, M. G. Tibiletti, Venat-Bouvet, L, K. Aittomaki, Gerdes, A.-M., Angel Pujana, Miquel,, Richard Rosenquist (262592), Stavropoulou, Alexandra V., Side, Lucy E., Mary B. Daly (196724), M. A. Pujana (7676753), Kruse, TA, Tihomirova, Laima, Mourits, M. J., Preisler-Adams, S, James, Paul A, Richard Rosenquist, Weitzel, Jeffrey N, Faivre, Laurence, Ellis, Steve, Leone, M., Kenneth Offit, M. B. Daly, Mai, P.L., Kuchenbaecker, Karoline B.,, Walker, Lisa, V. Attard, Marion Piedmonte, Eeles, R. A., B. Stayner, Jeffers, Lisa, L. Castera (7676645), Susan M. Domchek (154078), Murray, Alex,, J. Rantala, B. Buecher, Drakoulis Yannoukakos (4758), K. Harbst, A. Remenieras, J. N. Weitzel (7608107), Mia M. Gaudet, A. Jakubowska (7658414), Nathanson, K.L., Robson, M., Easton, Douglas F, J. Gronwald (7676654), Christian F Singer, Morrison, P.J., R. Davidson, Chenevix-Trench, G, Teule, Alex,, Phelan, C, Marion Piedmonte (238646), Ditsch, Nina,, Teo, Soo-Hwang, Matthew Kosel, Lester, Jenny,, Norbert Arnold (112045), K. Stevens (4256824), Eccles, DM, Plendl, Hansjoerg, M. B. Terry (7608047), Arver, B., I. S. Pedersen, Gauthier-Villars, Marion, F. Douglas, Gustavo C Rodriguez, K. B. Kuchenbaecker (7658228), Cohn, David E.,, Peter Devilee, McGuffog, Lesley,, Gehrig, A, Dominique Stoppa Lyonnet, E. J. van Rensburg (7658273), A. M. W. Van Den Ouweland, Olswold, Curtis,, Meijers-Heijboer, Hanne EJ, Einbeigi, Zakaria,, Dorkins, Huw,, Healey, S., Schmutzler R.K., Jacques Simard, Rodriguez, Gustavo C, Susan J. Ramus (205214), Devilee, Peter, Tripathi, Vishakha, Bignon, Y.J., Taru A. Muranen (395284), Karlan, B, Vincent, D, van Rensburg, Elizabeth J, Peissel, B., Hagay Sobol (91961), Daly, M. B., S. Preisler-Adams (7619522), Gehrig, Andrea,, Leroux, Dominique, Tischkowitz, M., C. E. Ardnor, Aalfs, C. M., Glendon, G., Lindor, Noralane M.,, Fergus J. Couch (146607), Angel Pujana, M., M. S. Beattie, B. A. Agnarsson (7676822), Lasset, Christine, T. R. Rebbeck, Blanco, Ingnacio, Stenmark-Askmalm, Marie, Castro, Elena, Louise Izatt, N. Ditsch (7676684), Kosel, M, Sara Volorio, Dorfling, Cecilia M, Antonis C. Antoniou (146788), David E. Cohn (395255), Damiola, Francesca, Andersen, M, Lasa, Adriana, G. Crawford, Mary S. Beattie (395206), Rouleau, E., Amanda Ewart Toland (164514), Katarzyna Jaworska (146755), Balmana, J., Durda, Katarzyna,, Couch, Fergus J., SWE-BRCA (7619690), Buys, Saundra S., Ramus, SJ, A. Searle, B. Bonanni, Remenieras, Audrey, R. B. Barkardottir, Houghton, C, Laitman, Y, J. Cunningham, Douglas, Fiona, Yannoukakos, D, S. Volorio, Karoline B. Kuchenbaecker (395191), Szabo, C, D. Eccles, Loud, Jennifer T, Georgia, Chenevix-Trench, Houlston, Richard, Montagna, Marco, Duran, M, Hamann, U., van Os, Theo A. M. +999 morecore +1 more sourceHippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà +11 morewiley +1 more source
