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Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees
Pediatric Blood &Cancer, EarlyView.ABSTRACT
Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern +7 morewiley +1 more sourceMammographic density and molecular subtypes of breast cancer. [PDF]
, 2012 BACKGROUND: Gene expression profiling has led to a subclassification of breast cancers independent of established clinical parameters, such as the Sorlie-Perou subtypes.Bergh, J, P Hall, J Bergh, Dos Santos Silva, I, K Czene, Hall, P, Eriksson, L, McCormack, V, Ploner, A, Czene, K, Bjohle, J, V McCormack, J Bjohle, A Ploner, L Eriksson, I dos Santos Silva, Silva, IDS, Hall, P,, Eriksson, L,, Ploner, A,, Bergh, J,, Czene, K, +21 morecore +1 more sourceNeoadjuvant camrelizumab plus nab-paclitaxel and epirubicin in early triple-negative breast cancer: a single-arm phase II trial
Nature Communications, 2023 Immunotherapy combined with chemotherapy has been demonstrated to be effective in early triple-negative breast cancer (TNBC). In this single-arm, phase II study with Simon’s two-stage design, we investigated the efficacy and safety of neoadjuvant ...Chengzheng Wang, Zhenzhen Liu, Xiuchun Chen, Jianghua Qiao, Zhenduo Lu, Lianfang Li, Xianfu Sun, Chongjian Zhang, Xiayu Yue, Qingxin Xia, He Zhang, Min Yan +11 moredoaj +1 more sourceCritical research gaps and translational priorities for the successful prevention and treatment of breast cancer [PDF]
, 2013 IntroductionBreast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating ...Gee, Julia M. W., Hulbert-Williams, Nicholas J., Anderson, Annie, Martin, S.G., Stingl, J., Key, Timothy, Hunter, MS, Walker, Rosemary, Martin, SG, Stephen Hiscox, O’Connor, Rosemary, Smalley, Matthew J., Aboagye, Eric, Williams, K.J., Christine J Watson, Annie S Anderson, Robert B Clarke, Bundred, Nigel, Tutt, Andrew N J, Jo Armes, Evans, D, Brown, N.J., Smalley, Matthew J, Clarke, R.B., Charles H. Streuli (7669838), Eric O Aboagye, Bundred, Nigel J., Groves, Ashley, Aboagye, Eric O., John M. Saxton (7244180), Watson, Christine, Watson, C.J., Montserrat Garcia-Closas (89866), Palmieri, C., Anderson, Annie S.; id_orcid, Miller, WR, Moss, SM, Evans, D., Burchell, JM, Nicola J. Brown (7596590), John F. Marshall (7957925), John M Saxton, Amanda J Harvey, Eccles, Suzanne A., Flanagan, James, Bharat Jasani, Fedor Berditchevski, Pharoah, Paul D.P., Marshall, John F., Stingl, John, Peter Schmid, Macdougall, J.E., Cliona C. Kirwan (3934682), Duffy, Stephen W, Leach, M.O., Stein, R., Eccles, Suzanne A, Hunter, Myra, Miller, William R., Howell, Anthony, Stewart G Martin, Edwards, Dylan R., Kunkler, IH, Silva, IDOSS, Miles, D.W., Paul D P Pharoah, Ian H. Kunkler (7957919), Young, L.S., Evans, DG, Galina Velikova, Goh, V., Kong, A., Jasani, Bharat, Watson, CJ, Paul DP Pharoah (7957952), Gee, JM, Streuli, CH, Berditchevski, F., Walker, R.A., Nick Hulbert-Williams, Groves, Ashley M., Moss, Sue, Sahai, E, Jones, LJ, Goh, Vicky, Leach, Martin O., Charlotte E Coles, Gary JR Cook, Berditchevski, F, Hennessy, Bryan T., Carroll, J.S., Gee, Julia MW, Jennifer E Macdougall, Armes, Jo, Garcia-Closas, M., Aboagye, Eric O, Martin, L.A., O'Connor, J.P.B., Anthony Howell (23576), Key, Timothy J, Mullan, P, Kaye J Williams, Harvie, Michelle N., Brown, NJ, Miles, David, Harvey, AJ, Rakha, Emad A, Isabel dos Santos Silva, Thompson, Alastair M., Palmieri, C, Miller, W.R., David W Miles, Velikova, Galina, Moss, S.M., Bryant, Helen E, Cox, A, Jo Armes (3480905), Reed, E., Eccles, Diana M., Marshall, JF, Cook, Gary J. R., William R Miller, Pharoah, P.D.P., Anderson, Annie S, Fedor Berditchevski (3827920), Duffy, SW, Young, Leonie, Nicola J Brown, Martin, Stewart, Hubbard, G., Saxton, John M., Dekker, Lodewijk, Brown, Nicola, Bundred, N.J., Martin, LA, Cox, Angela, Armes, J., William M. Gallagher (265756), Charlotte E. Coles (7688222), Andrew N J Tutt, Alastair M Thompson, Aboagye, EO, Simak Ali, Paul Mullan (6534653), Jones, Louise, Rosemary O'Connor (94873), Coles, Charlotte E, Evans, D. Gareth, Burchell, Joy, Jeremy P. Blaydes (7957853), Hiscox, Stephen, Deborah F. Fenlon (7957892), Robert Stein, Speirs, Valerie, Simon P. 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B., Carroll, Jason, Anderson, A.S., Gill Hubbard (3403994), Robinson, SP, Groves, Ashley M, Hulbert-Williams, N, Watson, Christine J, Amanda J. Harvey (7957904), Kirwan, Cliona C.; id_orcid, Speirs, V, Campbell, AM, Cook, Gary J., Bryant, Helen, Coles, Charlotte E., Fenlon, Deborah F., Martin, Lesley, Blaydes, Jeremy P, Martin O Leach, Erik Sahai, Ashley M. Groves (7957901), Williams, Kaye J., Langdon, Simon P., O’Connor, James P., Bryant, HE, Edwards, J, Blaydes, JP, Emad A Rakha, Morris, Joanna R., Groves, A.M., Louise J Jones, Thompson, AM, Easton, Douglas F., Dekker, LV, Jasani, B, Harvey, Amanda J., Howell, S.J., Anna M Campbell, Saxton, JM, Vicky Goh (577982), Leach, Martin O, Stephen W Duffy, Tutt, Andrew NJ, Ali, S., Blaydes, Jeremy P., Howell, Sacha J.; id_orcid, Louise J. Jones (7957916), Harvie, Michelle, Clarke, Robert B, Lesley Ann Martin, Garcia-Closas, Montserrat, Kunkler, Ian H., Angela Cox, Leach, MO, Fenlon, Deborah, dos Santos Silva, Isabel, Leonie Young (7895759), Pharoah, Paul D. P., Harvey, Amanda, Rakha, Emad, Jones, L.J., Morris, JR, Campbell, Anna, Kunkler, Ian H, Reed, Elizabeth, Douglas F Easton, Deborah F Fenlon, Berditchevski, Fedor, Coles, C.E., Gallagher, W.M., Carlo Palmieri (681317), Howell, A, Brennan, K, Rakha, EA, Rosemary A. Walker (7580297), Jeremy P Blaydes, Duffy, Stephen, Matthew J. Smalley (7957961), Sacha J Howell, Gescher, Andy, Macdougall, JE, Elizabeth Reed (3138513), Natrajan, R., O'Connor, R., Montserrat Garcia-Closas, Bundred, Nigel J, Nicola J. Curtin (351064), Holen, Ingunn, Carroll, JS, Goh, Vicky; id_orcid, Alastair M. Thompson (7957970), Bryan Hennessy (7898999), Cook, GJR, Brown, Nicola J, Reed, E, Kirwan, CC, Hunter, Myra S., Walker, Rosemary A., Robinson, S.P., Michelle Harvie, Duffy, S.W., Saxton, John, Ingunn Holen, Suzanne A Eccles (7957850), Brennan, K., Gallagher, William, Rosemary O’Connor, Isabel Dos Santos Silva (7957874), John Stingl, Andy J. Gescher (7671179), Joanna R Morris, Annie S. Anderson (6298127), Morris, Jo; id_orcid, Langdon, Simon, Rachel Natrajan (7957946), Ali, S, Hubbard, Gill, Vicky Goh, Sacha J. Howell (7957907), Smalley, M.J., Holen, I, Sahai, E., Helen E Bryant, Edwards, Dylan R, Edwards, D.R., Cliona C Kirwan, Stein, R, Simon P Robinson, Timothy J. Key (7755380), James M Flanagan, Martin, Lesley Ann, Nick Hulbert-Williams (7957910), Morris, Joanna, Brown, Nicola J., Silva, Isabel dos Santos, Nicola J Curtin, Foster, Claire, Kaye J. Williams (7957967), Paul Mullan, Nigel J. Bundred (7957859), Curtin, NJ, Gee, Julia M W, Eccles, Diana, Campbell, Anna M, Streuli, C.H., Tutt, Andrew, Fenlon, Deborah F, Clarke, Robert B., Mullan, P., Silva, IDS, Gee, J.M.W., Morris, J.R., Valerie Speirs (1679), O'Connor, James, Cook, Gary J R, O’Connor, James P.B., Campbell, A.M., Easton, DF, Watson, Christine J., Goh, V, Bryant, H.E., Eric O. Aboagye (309960), Marshall, J.F., Howell, Anthony; id_orcid, Burchell, Joy M, Tutt, AN, Easton, Douglas, Tutt, A.N.J., Jones, Louise J, Streuli, Charles H, Hiscox, S., Schmid, Peter, Joanne Edwards (589089), Gallagher, William M, Stingl, J, Dekker, L.V., Claire Foster, Robinson, Simon P, Curtin, Nicola, Gee, Julia, Tutt, ANJ, Howell, Sacha, Saxton, J.M., Foster, C., Miles, David W, Erik Sahai (829065), Thompson, A.M., Mullan, Paul, Kirwan, Cliona C, James PB O’Connor, Mann, DJ, Rakha, E.A., Pharoah, Paul DP, Helen E. Bryant (7957856), Burchell, Joy M., Natrajan, R, Harvie, M, Carlo Palmieri, Gescher, Andy J, Macdougall, Jennifer E, Hubbard, G, Hulbert-Williams, Nick, Mann, David, Clarke, Robert, Cook, Gary J.R., Anthony Howell, Dekker, Lodewijk V, Hennessy, B.T., Young, Leonie S., Joy M. Burchell (7957862), Foster, C, Key, T.J., Moss, Sue M, Williams, Kaye, Peter Schmid (81036), D Gareth Evans, Hubbard, Gill; id_orcid, Ashley M Groves, Curtin, Nicola J., Gescher, AJ, Joanna R. Morris (7957940), Clarke, RB, Streuli, Charles, Palmieri, Carlo, Martin O. Leach (454145), Mann, David J., Ingunn Holen (3637012), Marshall, John, Simon P Langdon, Bundred, NJ, Gill Hubbard, Keith Brennan (1659), Young, LS, Timothy J Key, Kong, A, dos Santos Silva, I, Eccles, SA, Marshall, John F, Miller, William, Fenlon, DF, Charles H Streuli, Langdon, SP, Pharoah, Paul, Hunter, M.S., Streuli, Charles H., Matthew J Smalley, Smalley, MJ, Kirwan, Cliona C., Christine J. Watson (7585901), Gescher, Andy J., Tutt, Andrew N. J., Kunkler, Ian, Robinson, Simon, Keith Brennan, O’Connor, R, Eccles, S.A., Cook, G.J.R., Valerie Speirs, Kong, Hee, Curtin, N.J., Dylan R. Edwards (7957886), Hiscox, S, Edwards, DR, Gary Jr Cook (7957868), Nigel J Bundred, Eccles, Diana M, James M. Flanagan (7957895), Leach, Martin, Speirs, V., James PB O'Connor (7957949), Howell, Sacha J., Joanne Edwards, Coles, Charlotte, Emad A. Rakha (7957955), Key, TJ, Carroll, Jason S, Rachel Natrajan, Stephen W. Duffy (7957877), Walker, RA, Kong, Anthony, Eccles, Suzanne, Miles, DW, Gallagher, William M., Curtin, Nicola J, Stewart G. Martin (7957931), Ali, Simak, Jones, Louise J., Bharat Jasani (4954081), Howell, Sacha J, Mann, David J, Valikova, G., Dylan R Edwards, Macdougall, Jennifer, Blaydes, Jeremy, Miles, David W., Miller, William R, Burchell, Joy M; id_orcid, Kunkler, I.H., Anderson, AS, Armes, J, Groves, AM, Diana M. Eccles (7957883), Mann, D.J., Andy J Gescher, Flanagan, James M., O'Connor, James P B, Eccles, D.M., Garcia-Closas, M, Flanagan, J.M., Kirwan, C.C., Pharoah, Paul D P, Leonie S Young, Ian H Kunkler, Anderson, Annie S., Hennessy, Bryan, dos Santos Silva, I., Deborah Fenlon, Myra S Hunter, O'Connor, JPB, Galina Velikova (3069645), Hiscox, Stephen Edward, Carroll, Jason S., David J Mann, Holen, I., Campbell, Anna M., Flanagan, JM, Aboagye, E.O., Pharoah, PD, Velikova, G, Harvey, Amanda J, Martin, Stewart G, Sahai, Erik, Martin, L, Stephen Hiscox (361114), Cook, Gary JR; id_orcid, Coles, CE, Williams, KJ, Silva, IS, Morris, Joanna R, Lodewijk V Dekker, Hennessy, BT, Thompson, Alastair M, Simak Ali (12335), Pharoah, PDP, Saxton, John M, Cook, GJ, Evans, D. G., Andrew NJ Tutt (7957964), Simon P. Langdon (7957922), Dekker, Lodewijk V., Anna M. Campbell (7957865), Moss, Sue M., Gee, JMW, Lesley A. Martin (7957928), Harvie, M., Clarke, Robert; id_orcid, O'Connor, Rosemary, Natrajan, Rachel, Cox, A., Edwards, J., Young, Leonie S, Anthony Kong, Smalley, Matthew, Diana M Eccles, William M Gallagher, Elizabeth Reed, Schmid, P, Brennan, Keith, Langdon, S.P., Duffy, Stephen W., Easton, D.F., Walker, Rosemary A, Kirwan, Cliona, Flanagan, James M, O'Connor, James Pb, Gallagher, WM, Martin, Lesley A., Anthony Kong (94738), Gee, Julia Margaret Wendy, Howell, SJ, Hunter, Myra S, Myra S. Hunter (7957913), Lodewijk V V. Dekker (7957871), William R. Miller (1372755), Robert Stein (1704328), John Stingl (444979), Jason S. Carroll (7901276), Burchell, J.M., Robert B. Clarke (7948805), Robinson, S P, Bryant, H E, Key, T J, Easton, D F, Watson, C J, Fenlon, D F, Pharoah, P D P, Tutt, A N J, Groves, A M, Jones, L J, Leach, M O, Coles, C E, Flanagan, J M, Gescher, A J, Mann, D J, Martin, S G, Morris, J R, Silva, I S, Walker, R A, Langdon, S P, Anderson, A S, Miller, W R, Moss, S M, Gallagher, W M, Burchell, J M, Saxton, J M, Rakha, E A, Harvie, Michelle N, Duffy, S W, Harvey, A J, Hunter, M S, Thompson, A M, Marshall, J F, Curtin, N J, Blaydes, J P, Hennessy, B T, Young, L S, Hulbert-Williams, Nick; id_orcid, Aboagye, E O, Brown, N J, Eccles, D M, Kunkler, I H, Smalley, M J, Eccles, S A, Edwards, D R, Dekker, L V, Macdougall, J E, Campbell, A M, Carroll, J S, Miles, D W, Cook, G J R, Evans, D Gareth R, Gee, J M W +645 morecore +3 more sourcesInvestigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post +3 morewiley +1 more sourceAn epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz +14 morewiley +1 more sourceA case of giant cell tumor of the breast, clinically suspected as malignant breast tumor
Surgical Case Reports, 2019 Background Giant cell tumor (GCT) of the breast is scarce. We report a case of GCT of the breast which was suspected as a malignant breast tumor. Case presentation A 74-year-old woman noticed a tender lump in her right breast.Mitsuo Terada, Naomi Gondo, Masataka Sawaki, Masaya Hattori, Akiyo Yoshimura, Haruru Kotani, Yayoi Adachi, Madoka Iwase, Ayumi Kataoka, Kayoko Sugino, Makiko Mori, Nanae Horisawa, Yuri Ozaki, Hiroji Iwata +13 moredoaj +1 more source