Results 31 to 40 of about 6,304,439 (300)

A Population-Based Study of Genes Previously Implicated in Breast Cancer

New England Journal of Medicine, 2021
BACKGROUND Population-based estimates of the risk of breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for risk assessment and management in women with inherited pathogenic variants.
Chunling Hu, S. Hart, Rohan D Gnanaolivu, Hongyan Huang, Kun Y. Lee, Jie Na, Chi Gao, J. Lilyquist, S. Yadav, N. Boddicker, R. Samara, J. Klebba, C. Ambrosone, H. Anton-Culver, P. Auer, E. Bandera, L. Bernstein, K. Bertrand, E. Burnside, B. Carter, Heather A. Eliassen, S. Gapstur, M. Gaudet, C. Haiman, James M. Hodge, D. Hunter, E. Jacobs, E. John, C. Kooperberg, A. Kurian, L. Le Marchand, S. Lindstroem, Tricia Lindstrom, Huiyan Ma, S. Neuhausen, P. Newcomb, K. O’Brien, J. Olson, I. Ong, T. Pal, J. Palmer, Alpa V. Patel, S. Reid, L. Rosenberg, D. Sandler, Christopher G. Scott, R. Tamimi, Jack A. Taylor, A. Trentham-Dietz, C. Vachon, C. Weinberg, S. Yao, A. Ziogas, J. Weitzel, D. Goldgar, S. Domchek, K. Nathanson, P. Kraft, E. Polley, F. Couch   +59 more
semanticscholar   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

A case of giant cell tumor of the breast, clinically suspected as malignant breast tumor

Surgical Case Reports, 2019
Background Giant cell tumor (GCT) of the breast is scarce. We report a case of GCT of the breast which was suspected as a malignant breast tumor. Case presentation A 74-year-old woman noticed a tender lump in her right breast.
Mitsuo Terada, Naomi Gondo, Masataka Sawaki, Masaya Hattori, Akiyo Yoshimura, Haruru Kotani, Yayoi Adachi, Madoka Iwase, Ayumi Kataoka, Kayoko Sugino, Makiko Mori, Nanae Horisawa, Yuri Ozaki, Hiroji Iwata   +13 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

DGKZ promotes TGFβ signaling pathway and metastasis in triple-negative breast cancer by suppressing lipid raft-dependent endocytosis of TGFβR2

Cell Death and Disease, 2022
Diacylglycerol kinase ζ (DGKZ) is a diacylglycerol kinase that metabolizes diacylglycerol to yield phosphatidic acid, and its function in breast cancer progression remains unclear. In this study, via screening of a CRISPR-Cas9 knockout library containing
Yuanyuan Zhao, Hefen Sun, Xuan Li, Qiqi Liu, Yang Liu, Yifeng Hou, Wei Jin   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Amyloid tumor of the breast

Surgical Case Reports, 2019
Background Amyloid tumor of the breast is a rare disease, which was first reported in 1973. To date, only six cases have been reported in Japan. Case presentation A 45-year-old woman who had a medical history of Sjogren’s syndrome presented with a lump ...
Makiko Mori, Haruru Kotani, Masataka Sawaki, Masaya Hattori, Akiyo Yoshimura, Naomi Gondo, Yayoi Adachi, Ayumi Kataoka, Kayoko Sugino, Nanae Horisawa, Mitsuo Terada, Yuri Ozaki, Hiroji Iwata   +12 more
doaj   +1 more source