Results 81 to 90 of about 9,188,168 (301)

BRCA1 and BRCA2 mutations in a population-based study of male breast cancer [PDF]

, 2001
Background: The contribution of BRCA1 and BRCA2 to the incidence of male breast cancer (MBC) in the United Kingdom is not known, and the importance of these genes in the increased risk of female breast cancer associated with a family history of breast ...
Bruce AJ Ponder, Julian M Lipscombe, Joanna M Ward, Basham, VM, Easton, DF, Ward, JM, Ponder, BAJ, Victoria M Basham, Simon A Gayther, Paul DP Pharoah, Lipscombe, JM, Douglas F Easton, Pharoah, PDP, Gayther, SA   +13 more
core   +2 more sources

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Unravelling Breast Cancer Risks and Early Detection Barriers in Above 30-Year-Old Women in Puducherry, India

National Journal of Community Medicine
Background: Breast cancer is the leading cause of cancer death among women all over the world and one of the most treatable cancers if detected early.
Sreya Prakash, Karthiga Vijayakumar, Kavita Vasudevan   +2 more
doaj   +1 more source

Increased prevalence of colorectal adenomas in women with breast cancer [PDF]

, 2005
Background: The frequency of colorectal adenomas and carcinomas was investigated in a large cohort of women with breast cancer in comparison with matched controls, since data on the occurrence of second tumors in women with breast cancer is controversial.
Späth, Lydia, Eiermann, Wolfgang, Sackmann, Michael, Göke, Burkhard, Ochsenkühn, Thomas, Wiebecke, Baldur, Bayerdörffer, Ekkehard, Meining, Alexander, Mannes, Gerd Alexander, Ochsenkühn, T;Bayerdörffer, E;Meining, A;Späth, L;Mannes, GA;Wiebecke, B;Eiermann, W;Sackmann, M;Göke, B   +9 more
core   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Maternal pelvic size not predictive of daughter's breast cancer or ovarian cancer in a large Swedish cohort. [PDF]

, 2009
Recent studies from Finland reported that maternal pelvic size predicted daughters' breast and ovarian cancer, possibly because maternal pelvic size is a marker for in utero hormone exposure.
Goodman, Anna, Silva, Isabel dos Santos, Silva Idos, S., Mishra, G.D., Koupil, Ilona,, Mishra, Gita D, Koupil, Ilona, Silva, Isabel D., Mishra, Gita D.   +8 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Organochlorines and Breast Cancer Risk

CA: A Cancer Journal for Clinicians, 2002
Organochlorines are a diverse group of synthetic chemicals that include polychlorinated biphenyls (PCBs), dioxins, and organochlorine pesticides such as dichlorodiphenyl-trichloroethane (DDT), lindane, and hexachlorobenzene. Although use of DDT and PCBs has been banned in the United States since the 1970s, some organochlorine compounds have accumulated
Eugenia E, Calle, Howard, Frumkin, S Jane, Henley, David A, Savitz, Michael J, Thun   +4 more
openaire   +2 more sources

Common variants in ZNF365 are associated with both mammographic density and breast cancer risk. [PDF]

, 2011
High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association ...
Boyd, Norman F, Paterson, AD, Hall, P, Couch, Fergus J, Stone, J, Nicholas J Wareham, Tamimi, Rulla M, Norman F Boyd, Peter Kraft, Jean Leyland, Apicella, Carmel, Easton, Douglas F, Hopper, John L, Darryl Waggott, Hall, Per, Hunter, DJ, Apicella, C, Loos, RJF, Kraft, Peter, Per Hall, Brown, J, Judith Brown, Jennifer Stone, Couch, FJ, Tamimi, RM, Silva, Isabel dos Santos, Dos Santos Silva, I, John L Hopper, Southey, MC, Celine M Vachon, Leyland, Jean, Hazra, Aditi, Hopper, JL, Hankinson, SE, Rommens, Johanna, Czene, Kamila, Deborah Thompson, David J Hunter, Louise Eriksson, Li, Jingmei, Paterson, Andrew D, Stephen J Chanock, Vachon, CM, Czene, K, Hankinson, Susan E, Easton, DF, Chanock, Stephen J, Liu, J, Andrew D Paterson, Lindström, Sara, Wareham, NJ, Vachon, Celine M, Aditi Hazra, Kraft, P, Ruth J F Loos, Scott, Christopher G, Wareham, Nicholas J, Thompson, D, Leyland, J, Boyd, NF, Scott, CG, Southey, Melissa C, Varghese, Jajini, Audley, T, Tina Audley, Rommens, J, Melissa C Southey, Pankratz, VS, Rulla M Tamimi, Eriksson, L, Waggott, D, Chanock, SJ, Jajini Varghese, Lisa J Martin, Varghese, J, Isabel dos Santos Silva, Kamila Czene, Waggott, Darryl, Li, J, Jingmei Li, Stone, Jennifer, Thompson, Deborah, Warren, R, JianJun Liu, Audley, Tina, Johanna Rommens, Douglas F Easton, Brown, Judith, Lindström, S, Pankratz, V Shane, V Shane Pankratz, Martin, LJ, Susan E Hankinson, Eriksson, Louise, Martin, Lisa J, Warren, Ruth, Carmel Apicella, Ruth Warren, Liu, JianJun, Hazra, A, Sara Lindström, Fergus J Couch, Hunter, David J, Christopher G Scott, Loos, Ruth JF, Li, J,, Lindstroem, S   +106 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source