Results 61 to 70 of about 584,073 (346)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Association of Breast Cancer Screening Behaviors With Stage at Breast Cancer Diagnosis and Potential for Additive Multi-Cancer Detection via Liquid Biopsy Screening: A Claims-Based Study

Frontiers in Oncology, 2021
PurposeTo evaluate mammography uptake and subsequent breast cancer diagnoses, as well as the prospect of additive cancer detection via a liquid biopsy multi-cancer early detection (MCED) screening test during a routine preventive care exam (PCE ...
Christine Hathaway, Peter Paetsch, Yali Li, Jincao Wu, Sam Asgarian, Alex Parker, Alley Welsh, Patricia Deverka, Ariella Cohain   +8 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Effects of nonparticipation at previous screening rounds on the characteristics of screen-detected breast cancers [PDF]

, 2022
Lucien E. M. Duijm, Mireille J. M. Broeders, Wikke Setz‐Pels, Vivian van Breest Smallenburg, Hermen C. van Beek, Astrid B. Donkers-van Rossum, Marjan J. Slob, Toon P. Kuipers, Ritse M. Mann, Adri C. Voogd   +9 more
openalex   +1 more source

Detection of Methylated Circulating DNA as Noninvasive Biomarkers for Breast Cancer Diagnosis [PDF]

, 2017
Internationally, breast cancer is the most common female cancer, and is induced by a combination of environmental, genetic, and epigenetic risk factors.
Cheuk, WY, Kwong, A, Shin, VY
core   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

"If diagnosed early, you will be stressed and die…" drivers for breast cancer screening services uptake among women in Dar es Salaam.

PLOS Global Public Health
Worldwide, there has been an increase in the breast cancer mortality rate, with disproportionately high rates in low and middle-income countries. Addressing breast cancer starts with early detection through screening services.
Nathanael Sirili, Khadija Msami, Thadeus Ruwaichi, Notikela Nyamle   +3 more
doaj   +1 more source

Interpretation of specification for breast cancer screening, early diagnosis, and treatment management in Chinese women

Journal of the National Cancer Center, 2021
Breast cancer has become the most common malignant tumor worldwide. However, the survival rate of breast cancer patients in China is 8% lower compared to that in European and American countries.
Fei Ma, Jiong Wu, Li Fu, Anhua Li, Bo Lan, Kexin Chen, Jiangli Di, Yuxin Jiang, Jing Li, Ni Li, Yexiong Li, Peifang Liu, Jinsong Lu, Lijuan Niu, Weijun Peng, Songjie Shen, Jufang Shi, Qiang Sun, Zhongsheng Tong, Jing Wang, Yong Wang, Shusen Wang, Yuntao Xie, Jianming Ying, Jin Zhang, Kai Zhang, Zhihui Zhang, Ying Zheng, Qingli Zhu, Binghe Xu   +29 more
doaj   +1 more source

A pilot telephone intervention to increase uptake of breast cancer screening in socially deprived areas in Scotland (TELBRECS):study protocol for a randomised controlled trial [PDF]

, 2014
BACKGROUND Breast cancer accounts for almost 30% of all cancers and is the second leading cause of cancer deaths in women in Scotland. Screening is key to early detection. The Scottish Breast Screening Programme is a nationwide, free at point of delivery
Alan Cook, Australian Government Department of Health and Ageing, C Abraham, Debbie Archibald, DG Altman, G Lawrence, G Libby, IM Rosenstock, JA Chambers, Julie A Chambers, Julie Cavanagh, KL Whitaker, LC Watson-Johnson, M Brouwers, R Millar, RC Baron, RE O’Carroll, RE O’Carroll, RE O’Carroll, RE O’Carroll, Ronan E O’Carroll, Rosemary Millar, T Sandberg, T Spadea, VB Sheppard   +24 more
core   +4 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source